M. Docteur TOMASZ SZAFRANSKI

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• CABINET DU DR TOMASZ SZAFRANSKI

  CLINIQUE CONTI — 3 CHEMIN DES 3 SOURCES, 95290 L'Isle-Adam

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Top publications · les plus citées

• 1

  Psychiatric manifestations in Wilson's disease: possibilities and difficulties for treatment

  Therapeutic advances in psychopharmacology · 2018

  📚 93 citations🎯 RCR 5.96Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Wilson’s disease (WD) is an inherited metabolic disorder related to disturbances of copper metabolism, and predominantly presents with liver and neuropsychiatric symptoms. In most cases it can be successfully treated with anti-copper agents, and both liver function and neuropsychiatric symptoms typically improve. Treatment guidelines for WD include recommendations for anti-copper treatment as well as for the treatment of liver failure symptoms. Recently, recommendations for treatment of the neurological symptoms of WD have also been proposed. Although most WD patients present with psychiatric symptoms at some stage of the disease, currently there are no guidelines for the treatment of the psychiatric manifestations. Treatment of the psychiatric symptoms of WD is often guided by general psychiatric experience, which typically glosses over the specificity of WD, and can result in severe neurological and/or hepatic complications. Here we review and discuss the possible treatments available for the mood disturbances, psychosis, behavioral and cognitive disorders that can occur in WD, as well as their efficacy.

• 2

  Treatment of depression in first episode of schizophrenia: results from EUFEST

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012

  📚 21 citations🩺 Clinique
• 3

  Electroencephalogram slowing, sleepiness and treatment response in patients with schizophrenia during olanzapine treatment

  Journal of psychopharmacology (Oxford, England) · 2006

  📚 14 citations

  Lire l'abstract Crossref ↓

  Electroencephalogram (EEG) slowing is associated with clozapine side effects, e.g., sedation, and may predict treatment response during clozapine treatment. As olanzapine and clozapine share many pharmacological properties, we investigated whether EEG slowing during olanzapine treatment was related to therapy outcome and sleepiness in patients with schizophrenia. Participants were age- and gender-matched schizophrenic patients treated with olanzapine ( n 54), receiving no pharmacological treatment ( n 54), or cotreated with olanzapine and some other psychotropic drug ( n 38). Their EEG recordings were assessed visually by the same rater blind to clinical data. The EEG scores were categorized using standardized forms. Patients with a poor treatment response did not differ significantly from those with a good response to treatment either in EEG patterns or in frequency of sleepiness. Olanzapine treatment was associated with increased rates of slow (70.4% vs. 22.3%) and sharp waves (22.2% vs. 7.4%), as well as of paroxysmal slow wave discharges (14.8% vs. 1.9%), but did not induce spike- or sharp-slow-wave complexes. Cotreatment with another antipsychotic further increased EEG abnormalities, whereas benzodiazepine administration diminished the olanzapine-induced EEG changes. The results show that olanzapine inducing both slow and sharp waves, as well as paroxysmal discharges, has a strong impact on EEG. However, as no spike- or sharp-slow-wave complexes were observed, the risk of epileptic seizure during olanzapine treatment can be regarded as low, as long as olanzapine is not combined with some other antipsychotic.

Publications scientifiques (15) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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