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Rhumatologue

Docteur Denis ROLLAND

📍 Bourges (18)MixteRPPS 10001979490
📊 Reconnaissance scientifique : 7/100📝 111 articles publiés📚 HAL (8)

✨ Profil synthétique

IA · 30/04/2026

Le Docteur Denis ROLLAND est un rhumatologue exerçant à Bourges. Ses recherches académiques sont principalement axées sur les études historiques et culturelles, ainsi que sur les analyses socio-culturelles. Il a publié 111 travaux et possède un h-index de 7 sur OpenAlex. Ses publications sur PubMed couvrent des sujets tels que la corticothérapie, l'épidémiologie et les essais cliniques en rhumatologie.

Expertises présumées

  • Corticothérapie
  • Épidémiologie en rhumatologie
  • Essais cliniques en rhumatologie
  • Lombalgie
  • Pharmacovigilance en rhumatologie

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

Diplômes

🎓 DES & spécialité ordinale

  • Rhumatologie (SM)

📚 CES (Certificat d'Études Spéciales)

  • CES Rhumatologie

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

7

h articles cités ≥ h fois chacun. Un h de 7 = 7 publications avec 7+ citations.

Citations

208

Publications

111

i10-index

4

Thématiques principales

  • French Historical and Cultural Studies ×26
  • Historical Studies and Socio-cultural Analysis ×16
  • Multiculturalism, Politics, Migration, Gender ×14
  • French Urban and Social Studies ×13
  • European Political History Analysis ×8

Affiliations FR : Université de Strasbourg

Voir sur OpenAlex ↗

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation des cabinets

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

📊 Comprendre le remboursement

Prendre rendez-vous & contact

🗓 Trouver sur Doctolib📇 Ajouter à mes contacts

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (4)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Top publications · les plus citées

  • 1
    Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis

    Arthritis and rheumatism · 2002

    📚 75 citations🎯 RCR 1.92
    Lire l'abstract Crossref ↓

    AbstractObjectiveTo assay antifilaggrin autoantibodies, we developed an enzyme‐linked immunosorbent assay (ELISA) using a “citrullinated” recombinant rat filaggrin. Our objectives were to assess its value for diagnosing rheumatoid arthritis (RA) and to compare the results with those obtained using 4 other reference methods for detection of antifilaggrin autoantibodies, including the commercially available ELISA that uses a modified “citrullinated” synthetic peptide derived from the sequence of human filaggrin (CCP‐ELISA).MethodsWe analyzed 711 sera from patients with well‐characterized rheumatic diseases, including 240 patients with RA. Antifilaggrin autoantibodies were detected by an ELISA using a recombinant rat filaggrin deiminated in vitro as immunosorbent (ArFA‐ELISA). The results considered were the differences between the optical densities obtained on deiminated and nondeiminated proteins. Antibodies to rat esophagus epithelium were detected by indirect immunofluorescence, while antibodies to human filaggrin were detected by immunoblotting and by a recently described ELISA using a deiminated recombinant human filaggrin. Finally, CCP‐ELISA was performed according to the manufacturer's recommendations.ResultsAt the titer thresholds allowing diagnostic specificities of 0.95, 0.985, and 0.99 to be reached, the diagnostic sensitivities of the ArFA‐ELISA were 0.76, 0.67, and 0.65, respectively. At these 3 thresholds, the sensitivities were significantly higher than those of the 4 other tests. Despite incomplete overlapping of the 5 tests, the high diagnostic performance of the ArFA‐ELISA allows us to propose this test to replace all the other methods for antifilaggrin autoantibody detection.ConclusionArFA‐ELISA appears to be the most efficient test among those available for the detection of antifilaggrin autoantibodies, in terms of diagnostic accuracy for RA. Its diagnostic performance in early RA and its prognostic value are currently under evaluation.

  • 2
    Management of osteoarthritis (OA) with an unsupervised home based exercise programme and/or patient administered assessment tools. A cluster randomised controlled trial with a 2x2 factorial design

    Annals of the rheumatic diseases · 2004

    📚 71 citations🎯 RCR 2.65Top 19% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗
  • 3
    Autoantibodies recognizing citrullinated rat filaggrin in an ELISA using citrullinated and non-citrullinated recombinant proteins as antigens are highly diagnostic for rheumatoid arthritis

    Clinical and experimental immunology · 2004

    📚 69 citations🎯 RCR 2.15Top 24% NIH🔓 Open Access
    Lire l'abstract Crossref ↓

    SUMMARYThe objective of the study was to determine the diagnostic value for rheumatoid arthritis (RA) of anti-filaggrin autoantibodies (autoAb) recognizing citrullinated recombinant rat filaggrin (ACRF) in community cases of very early arthritis. To evaluate the diagnostic value of ACRF, were studied sera from patients with different classified rheumatic diseases and healthy subjects (group 1, n= 422) and 314 community cases of very early arthritis (group 2) that were classified as RA (n = 176), non-RA (n = 63) and undifferentiated (n = 75) arthritides after 1 years of follow-up. ACRF were measured using a new ELISA, with results expressed as the difference between the OD value obtained on citrullinated minus that on noncitrullinated rat filaggrin (differential ACRF; dACRF). For both groups, rheumatoid factors (RF), anti-keratin autoAb (AKA) and anti-perinuclear factor (APF) were tested; for group 2, anti-CCP autoAb were also tested. Different reactivity patterns against citrullinated and noncitrullinated filaggrin were observed. Almost all sera reacting with citrullinated but not noncitrullinated filaggrin were from RA patients. Among RA and non-RA sera that recognized both forms of filaggrin, a positive result was obtained only with RA sera. For groups 1 and 2, dACRF sensitivity was 58·4% and 30·7%, and specificity for RA was 99·5% and 98·4%, respectively. In group 2, dACRF specificity for RA was better than that of RF (92·1%), APF (95·2%), AKA (96·8%) and anti-CCP (95·2%). dACRF positive predictive value was high (98·2) and close to that given by the concomitant positivity of RF and anti-CCP autoAb. Despite a high positive correlation between AKA, APF, anti-CCP and dACRF test results, they were complementary since some sera were positive for only one test. Thus, in a community setting, anti-citrullinated rat filaggrin reactivity detected by a new ELISA, whose originality is based on the difference between serum's reactivities on the citrullinated and native forms of filaggrin, had a higher diagnostic value for RA than other autoAb.

Publications scientifiques (10) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal5

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Corticothérapie1

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Épidémiologie & registres1

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Essai clinique1

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Lombalgie1

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Pharmacovigilance1

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