Docteur ROBERT BARBE

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Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Comparative genomics of multidrug resistance in Acinetobacter baumannii

  PLoS genetics · 2006

  📚 600 citations🎯 RCR 17.59Top 1% NIH🔓 Open Access📄 PDF gratuit ↗
• 2

  Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome

  Proceedings of the National Academy of Sciences of the United States of America · 2003

  📚 298 citations🎯 RCR 6.30Top 5% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  Prochlorococcus marinus , the dominant photosynthetic organism in the ocean, is found in two main ecological forms: high-light-adapted genotypes in the upper part of the water column and low-light-adapted genotypes at the bottom of the illuminated layer. P. marinus SS120, the complete genome sequence reported here, is an extremely low-light-adapted form. The genome of P. marinus SS120 is composed of a single circular chromosome of 1,751,080 bp with an average G+C content of 36.4%. It contains 1,884 predicted protein-coding genes with an average size of 825 bp, a single rRNA operon, and 40 tRNA genes. Together with the 1.66-Mbp genome of P. marinus MED4, the genome of P. marinus SS120 is one of the two smallest genomes of a photosynthetic organism known to date. It lacks many genes that are involved in photosynthesis, DNA repair, solute uptake, intermediary metabolism, motility, phototaxis, and other functions that are conserved among other cyanobacteria. Systems of signal transduction and environmental stress response show a particularly drastic reduction in the number of components, even taking into account the small size of the SS120 genome. In contrast, housekeeping genes, which encode enzymes of amino acid, nucleotide, cofactor, and cell wall biosynthesis, are all present. Because of its remarkable compactness, the genome of P. marinus SS120 might approximate the minimal gene complement of a photosynthetic organism.

• 3

  The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution

  Proceedings of the National Academy of Sciences of the United States of America · 2006

  📚 283 citations🎯 RCR 8.27Top 3% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  Lactobacillus delbrueckiissp.bulgaricus(L. bulgaricus) is a representative of the group of lactic acid-producing bacteria, mainly known for its worldwide application in yogurt production. The genome sequence of this bacterium has been determined and shows the signs of ongoing specialization, with a substantial number of pseudogenes and incomplete metabolic pathways and relatively few regulatory functions. Several unique features of theL. bulgaricusgenome support the hypothesis that the genome is in a phase of rapid evolution. (i) Exceptionally high numbers of rRNA and tRNA genes with regard to genome size may indicate that theL. bulgaricusgenome has known a recent phase of important size reduction, in agreement with the observed high frequency of gene inactivation and elimination; (ii) a much higher GC content at codon position 3 than expected on the basis of the overall GC content suggests that the composition of the genome is evolving toward a higher GC content; and (iii) the presence of a 47.5-kbp inverted repeat in the replication termination region, an extremely rare feature in bacterial genomes, may be interpreted as a transient stage in genome evolution. The results indicate the adaptation ofL. bulgaricusfrom a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation withStreptococcus thermophilus.

Publications scientifiques (9) — classées par pathologie

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