📇 Rhumatologue · VIRE · (14) · Mixte

M Kim WEGENER

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Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
36 articles scientifiques publiés — un praticien à la pointe de la recherche
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Délais de RDV courts dans la région
150.8 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 VIRE (14)MixteRPPS 10000815539

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR Kim WEGENER
CLINIQUE NOTRE DAME 23 RUE DES ACRES, 14500 VIRE
Activité de soin et de pharmacie
GHU APHP SUN SITE PITIE SALPETRIERE
47-83 47 BD DE L HOPITAL, 75651 PARIS CEDEX 13
☎ 0142160000Activité de soin et de pharmacie

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease

Arthritis and rheumatism · 2003

📚 161 citations🎯 RCR 4.32Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractObjectiveTo identify and recombine a protein of the human dermal microvascular endothelial cell (HDMEC) that specifically reacts with anti–endothelial cell antibody (AECA) in the serum of patients with Behçet's disease (BD), and to evaluate the usefulness of this protein in BD.MethodsThe proteomics technique, with 2‐dimensional gel electrophoresis and matrix‐assisted laser desorption ionization−time‐of‐flight (MALDI‐TOF) mass spectrometry, was used to identify and recombine HDMEC antigen. Western blotting and enzyme‐linked immunosorbent assay (ELISA) of recombinant protein isolated by gene cloning were performed on serum from healthy controls, patients with BD, and patients with other rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, and Wegener's granulomatosis).ResultsEighteen of 40 BD patients had serum IgM antibody to HDMEC antigen. The purified protein that reacted with AECA in BD patient sera was found to be α‐enolase by 2‐dimensional gel electrophoresis followed by immunoblotting and MALDI‐TOF mass spectrometry. Recombinant α‐enolase protein was isolated and refined by gene cloning. On Western blots, AECA‐positive IgM from the sera of patients with active BD reacted strongly with recombinant human α‐enolase. BD patient sera positive for anti–α‐enolase did not react with human γ‐enolase. On dot‐blotting, reactivity to human α‐enolase was detected only in the IgM‐positive group. Fifteen of the 18 AECA‐positive sera that were positive for the HDMEC antigen showed reactivity to recombinant α‐enolase IgM antibody by ELISA.ConclusionThe α‐enolase protein is the target protein of serum AECA in BD patients. This is the first report of the presence of IgM antibodies to α‐enolase in endothelial cells from the serum of BD patients. Although further studies relating this protein to the pathogenesis of BD will be necessary, α‐enolase and its antibody may prove useful in the development of new diagnostic and treatment modalities in BD.

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood

Arthritis and rheumatism · 2009

📚 126 citations🎯 RCR 4.41Top 9% NIH

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AbstractObjectiveTo compare the criteria for Wegener's granulomatosis (WG) of the American College of Rheumatology (ACR) with those of the European League Against Rheumatism/Pediatric Rheumatology European Society (EULAR/PRES) in a cohort of children with WG and other antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs), and to describe the interval to diagnosis, presenting features, and initial treatment for WG.MethodsEligible patients had been diagnosed by site rheumatologists (termed the “MD diagnosis”) since 2004. This diagnosis was used as a reference standard for sensitivity and specificity testing of the 2 WG classification criteria. Descriptive analyses were confined to ACR‐classified WG patients.ResultsMD diagnoses of 117 patients (82 of whom were female) were WG (n = 76), microscopic polyangiitis (n = 17), ANCA‐positive pauci‐immune glomerulonephritis (n = 5), Churg‐Strauss syndrome (n = 2), and unclassified vasculitis (n = 17). The sensitivities of the ACR and EULAR/PRES classification criteria for WG among the spectrum of AAVs were 68.4% and 73.6%, respectively, and the specificities were 68.3% and 73.2%, respectively. Two more children were identified as having WG by the EULAR/PRES criteria than by the ACR criteria. For the 65 ACR‐classified WG patients, the median age at diagnosis was 14.2 years (range 4–17 years), and the median interval from symptom onset to diagnosis was 2.7 months (range 0–49 months). The most frequent presenting features by organ system were constitutional (89.2%), pulmonary (80.0%), ear, nose, and throat (80.0%), and renal (75.4%). Fifty‐four patients (83.1%) commenced treatment with the combination of corticosteroids and cyclophosphamide, with widely varying regimens; the remainder received methotrexate alone (n = 1), corticosteroids alone (n = 4), or a combination (n = 6).ConclusionThe EULAR/PRES criteria minimally improved diagnostic sensitivity and specificity for WG among a narrow spectrum of children with AAVs. Diagnostic delays may result from poor characterization of childhood WG. Initial therapy varied considerably among participating centers.

Radiologic features of vasculitis involving the gastrointestinal tract

Radiographics : a review publication of the Radiological Society of North America, Inc · 2000

📚 125 citations🎯 RCR 4.87Top 8% NIH

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M Kim WEGENER

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Top publications · les plus citées

Publications scientifiques (36) — classées par pathologie

Vascularites18

Case report / série5

Transversal5

Revue générale3

Biothérapies non-anti-TNF2

Revue / méta-analyse2

IA en rhumatologie1

Pharmacovigilance1

Vascularites des gros vaisseaux1

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