📇 Rhumatologue ·
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Praticien-chercheur
6 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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Scandinavian journal of immunology · 1990
Mouse monoclonal antibodies against ED sequence‐containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rhcumatoid synovial membrane and in the walls of small vessels in the synovium by immunofluorescence microscopy. cFn was also found in rheumatoid synovial fluid by immunoblotting. Approximately one‐fifth of the T lymphocytes from rheumatoid synovial fluid bound to Fn, The binding of synovial fluid T cells was always higher than that from peripheral blood. These results have two implications. On the one hand, the cellular type of Fn may be an indicator of synovial inflammation. On the other hand, the deposition of Fn may be a factor contributing to the infiltration ol mononuclear cells into the synovium.
The Journal of rheumatology · 2004
Acta paediatrica (Oslo, Norway : 1992) · 2004
Objective: To study the autoimmune response in mothers of children with congenital heart block (CHB) diagnosed at different ages and with different clinical manifestations. Patients and methods: Clinical data and sera for the determination of immunological tests were available from 104 mothers of 113 children born between 1950 and 2000 and diagnosed with CHB before the age of 16 y. Prenatal diagnosis was performed in 74 (65%) children of 65 mothers, and 39 (35%) children had postnatal diagnosis of CHB. Maternal antibodies to 52 kd and 60 kd SS‐A, and to 48 kd SS‐B were determined by time‐resolved fluoroimmunoassay (TR‐FIA) and to antinuclear antibodies (ANA) by immunoflurescense (IF). Results: Out of the 65 mothers of children with in utero diagnosed CHB, 88% had antibodies to 52 kd SS‐A and 83% had ANA. Antibodies to 60 kd SS‐A and 48 kd SS‐B were less frequently present, in 48% and in 54% of the mothers, respectively. Seven (11 %) of the mothers were negative by all immunoassays. Of the 13 mothers of children with in‐infancy diagnosed CHB, one mother had high‐titer ANA. After 1 y of age, CHB was diagnosed in 26 children; at 1 to 6 y in 16 and after 7 y in 10 children; 1/16 and 1/10 patients had positive antibodies. In all twin pregnancies (n= 4) and in all families with recurring cases of CHB (n= 5), maternal antibodies were positive in at least one assay. The titer of 48 kd anti‐SS‐B antibodies was significantly higher in children with cutaneous neonatal lupus (98.1 vs 41.0; p= 0.02). All mothers whose children died before the age of 4 y (n= 8) and 85 % (11/13) of mothers whose children developed cardiomyopathy had elevated antibody titers in at least one assay. However, we could not find any prognostic value of maternal antibody levels or specificities on the clinical outcome of the children with CHB.Conclusions: Although rare, late detection or postnatal progression of CHB in antibody‐mediated CHB should be taken into consideration. Maternal antibody levels or specificities have prognostic effect neither on the clinical outcome of the child with CHB nor on the risk of reappearance in the same family.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Scandinavian journal of rheumatology · 2005 · Journal Article
Julkunen H, Salonen EM, Walle TK, Miettinen A
Annals of the rheumatic diseases · 2004 · Comparative Study
Salonen EM, Miettinen A, Walle TK, Koskenmies S, et al.
Acta paediatrica (Oslo, Norway : 1992) · 2004 · Journal Article
Eronen M, Miettinen A, Walle TK, Chan EK, et al.
The Journal of rheumatology · 2004 · Journal Article
Julkunen H, Miettinen A, Walle TK, Chan EK, et al.
Scandinavian journal of immunology · 1994 · Journal Article
Walle TK, Helve T, Virtanen I, Kurki P
Scandinavian journal of immunology · 1990 · Journal Article
Walle TK, Vartio T, Helve T, Virtanen I, et al.
✨ Profil synthétique
IA · 25/05/2026M. Thierry WALLE est un rhumatologue qui a publié des travaux sur PubMed, notamment sur le lupus et en pédiatrie. Ses recherches suggèrent une expertise dans le domaine de la rhumatologie pédiatrique. Il a contribué à l'avancement des connaissances sur le lupus dans cette population spécifique.
Expertises présumées
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.