📇 Rhumatologue · Salarié
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Auteur de référence en rhumatologie
37 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
Stem cells translational medicine · 2021
Abstract Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. The present study was conducted to further assess the safety and efficacy of Stempeucel in critical limb ischemia due to Buerger's disease after obtaining approval from Indian FDA based on the data generated in the phase II study. This is an open label, multicenteric phase IV PMS study conducted across India with experienced vascular surgeons. Fifty patients of critical limb ischemia due to Buerger's disease with Rutherford III-5 or III-6 were included in the study and each individual received a dose of 2 million cells/kg body weight of Stempeucel in the calf muscles and around the ulcer. These patients were evaluated over 12 months from drug administration. The present study showed the continued long term efficacy over a period of 12 months follow up in these patients corroborating the result obtained in the previous phase II studies. There was significant improvement in rest pain, ankle systolic pressure, and ankle brachial pressure index with accelerated ulcer healing. In conclusion, the present study shows that the intramuscular administration of Stempeucel continues to be safe, tolerable, and effective alternative treatment in patients with Buerger's disease.
The Journal of the Association of Physicians of India · 2022
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The Journal of international medical research · 2026 · Journal Article
Been Sayeed SKJ, M M, Mahmud R, Rahman S, et al.
The New Zealand medical journal · 2026 · Journal Article
Thomsen P, Tan K, Brown-Acton P, Manuela S, et al.
JMIR research protocols · 2025 · Journal Article
Tautolo ES, Bakir-Demir T, Jalili-Moghaddam S, Savila F, et al.
Bioinformation · 2025 · Journal Article
G N, M SSL, V S, K S, et al.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025 · Journal Article
Josko B, Marko B, Domagoj G, Manuela F, et al.
Nursing in critical care · 2025 · Journal Article
Villa M, Ausili D, Pegoraro F, Nava G, et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024 · Journal Article
Severi S, Grassi I, Bongiovanni A, Nicolini S, et al.
Journal of visualized experiments : JoVE · 2024 · Journal Article
Alfaiate D, Mas-Moruno C, Manuela C, Ustrell JM, et al.
Brain, behavior, & immunity - health · 2023 · Journal Article
Graïc JM, Finos L, Vadori V, Cozzi B, et al.
PLoS neglected tropical diseases · 2023 · Journal Article
Guttapadu R, Prakash N, M A, Chatterjee R, et al.
medRxiv : the preprint server for health sciences · 2022 · Preprint
Ghosh P, Niesen MJM, Pawlowski C, Bandi H, et al.
Clinical hematology international · 2022 · Journal Article
Mahuad C, Victoria O, Laura K, Enriqueta M, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.
Current psychiatry reports · 2025 · Journal Article
Stowell M, Ramalho R, Manuela S, Newcombe D, et al.
Nutrition (Burbank, Los Angeles County, Calif.) · 2025 · Journal Article
Muzzioli L, Scenna D, Frigerio F, Manuela S, et al.
Archives of gerontology and geriatrics · 2021 · Journal Article
M R, M A, H B, M O
Clinical rheumatology · 2025 · Journal Article
A K, M EA, M H, H A, et al.
Rheumatology and immunology research · 2024 · Journal Article
Datta D, Khatun M, Bankura B, Sarkar M, et al.
Orphanet journal of rare diseases · 2025 · Journal Article
Berta ZC, Zaida MR, de Aragón Ana M, Noemí NE, et al.
JMIR research protocols · 2025 · Journal Article
M A, Ahmad A, A A, Raj LS, et al.
Physiotherapy · 2026 · Letter
Rashid FA, M RP
PloS one · 2022 · Journal Article
Baldassari I, Oliverio A, Krogh V, Bruno E, et al.
Current psychiatry reports · 2025 · Journal Article
Stowell M, Ramalho R, Manuela S, Newcombe D, et al.
Frontiers in psychology · 2021 · Journal Article
Manuela F, Barcos-Munoz F, Monaci MG, Lordier L, et al.
JACC. Case reports · 2024 · Case Reports
Kharge JL, M UK, M L J, Newaskar AA, et al.
Stem cells translational medicine · 2021 · Clinical Trial, Phase IV
Gupta PK, Dutta S, Kala S, Nekkanti M, et al.
Nutrition (Burbank, Los Angeles County, Calif.) · 2025 · Journal Article
Muzzioli L, Scenna D, Frigerio F, Manuela S, et al.
Cureus · 2023 · Journal Article
M D, Kumar J, Ramalingam K
Cureus · 2024 · Case Reports
Surapaneni D, Dasi SC, Sam N, M J
Clinical rheumatology · 2025 · Journal Article
Mohan A, Mohan A, Ramachandran A, Pulinilkunnathil JG, et al.
The Journal of the Association of Physicians of India · 2022 · Journal Article
Murugesan H, Cs G, Nasreen HS, Santhanam S, et al.
BMJ case reports · 2025 · Journal Article
Pathrot D, Nachappa AA, Mannual S, M SK
Indian journal of dermatology, venereology and leprology · 2023 · Letter
Rao AG, M N, Ch S, Jhawar J
Radiology case reports · 2023 · Case Reports
Lee ZR, Lai YK, M L, Khor LY, et al.
Orphanet journal of rare diseases · 2025 · Journal Article
Berta ZC, Zaida MR, de Aragón Ana M, Noemí NE, et al.
Pharmacoepidemiology and drug safety · 2026 · Journal Article
Boccia A, Hyeraci G, Girardi A, Gini R, et al.
Cureus · 2025 · Journal Article
Nallaperumal S, V P, M C V, Pusapati LCV, et al.
Nutrition (Burbank, Los Angeles County, Calif.) · 2025 · Journal Article
Muzzioli L, Scenna D, Frigerio F, Manuela S, et al.
Cureus · 2022 · Case Reports
Chandra MS, G A M, M RK
Cureus · 2024 · Case Reports
Mohan A, Kuriakose SM, James L, G BT, et al.
Experimental and therapeutic medicine · 2021 · Journal Article
Năstase F, Radaschin DS, Niculeț E, Stefanescu BI, et al.