M Huu-phuoc TRAN

Rhumatologue

RPPS 10000798651

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37ans d'exercice (thèse 1989)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Traitement du syndrome d'apnees du sommeil par la pression positive continue par voie nasale : a propos de 10 observations
1989
Médecine🎓 Amiens
Direction : Prosper-Parfait Goubaux

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

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Top publications · les plus citées

Usefulness of bone mineral density to predict significant coronary artery disease

The American journal of cardiology · 2005

📚 153 citations🎯 RCR 3.78Top 12% NIH

Rivaroxaban and false positive lupus anticoagulant testing

Thrombosis and haemostasis · 2011

📚 56 citations🎯 RCR 1.88🩺 Clinique

Anti-La/SSB antibodies transported across the placenta bind apoptotic cells in fetal organs targeted in neonatal lupus

Arthritis and rheumatism · 2002

📚 50 citations🎯 RCR 1.03

Lire l'abstract Crossref ↓

AbstractObjectiveTo determine whether La and/or Ro epitopes on apoptotic cells in fetal organs that are targeted in neonatal lupus syndrome (NLS) are accessible for binding by autoantibodies in vivo, we traced the fate of transplacental autoantibodies in a murine passive transfer model.MethodsPregnant mice at day 15 of gestation (E15) were injected intraperitoneally with human anti‐Ro/La–positive sera or control sera, and transplacental transfer of human autoantibodies was tested by enzyme‐linked immunosorbent assay with recombinant antigens. Multiple cryostat sections at the level of the heart of E17 fetuses were visualized simultaneously for human IgG binding and apoptosis (TUNEL) under confocal microscopy. Serial paraffin sections of E17 and E19 fetuses were examined for histologic evidence of inflammation.ResultsHuman IgG anti–52‐kd Ro, anti–60‐kd Ro, and anti‐La autoantibodies were transported efficiently into the fetal circulation. Human IgG–apoptotic cell complexes were detected in the heart (atrial trabeculae and atrioventricular node), skin, liver, and newly forming bone of fetuses from mothers injected with anti‐Ro/La sera but not control sera. The IgG binding was fetal‐specific and organ‐specific; transplacental autoantibodies did not bind to apoptotic cells in the fetal thymus, lung, brain, or gut. The complexes were not associated with an inflammatory reaction. Injection of mothers with affinity‐purified anti‐La autoantibodies (but not anti‐Ro/La Ig depleted of anti‐La) revealed an identical location of IgG binding to apoptotic cells in the fetuses.ConclusionThis is the first study to demonstrate that transplacental anti‐La autoantibodies bind specifically to apoptotic cells in selected fetal organs in vivo, similar to the organ involvement in NLS. We hypothesize that additional factors are required to promote proinflammatory clearance of IgG–apoptotic cell complexes and subsequent tissue damage.

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Publications scientifiques (26) — classées par pathologie

Transversal10

Génétique3

Revue générale3

Lupus2

Pédiatrie2

SAPL2

Case report / série1

Épidémiologie & registres1

IRM ostéo-articulaire1

Santé mentale / fatigue1

Vraie vie / RWE1

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