📇 Rhumatologue · PARIS 13E ARRONDISSEMENT · (75) · Salarié
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4 raisons identifiées
Auteur de référence en rhumatologie
24 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Expérience confirmée
26 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
26ans d'exercice (thèse 2000)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Exploring the role of the activin A-ActRIIB pathway in sickle cell disease-associated nephropathy and sarcopenia : mechanistic insights and therapeutic potential
2024Doctorant·e : Christine Ibrahim
Implication de la Vasorine et de la voie de l'EGFR dans la quiescence podocytaire et l'homéostasie glomérulaire en physiologie et pathologies rénales
2022Doctorant·e : Julien Dang
Étude de la modulation du récepteur TREM-1 dans la drépanocytose
2019Doctorant·e : Thomas Mintz
Implication des facteurs locaux (CD9, HB-EGF, PDGF-BB) au sein des cellules épithéliales pariétales glomérulaires au cours de la glomérulonéphrite extracapillaire et de la hyalinose segmentaire et focale : Études in vitro et in vivo
2019Doctorant·e : Hélène Lazareth
Implication de l'endotheline-1 dans l'adhérence et l'activation des polynucléaires neutrophiles dans la drépanocytose
2017Doctorant·e : Bérengère Koehl
Rôle du récepteur myéloïde à l’endothéline (ETB) au cours de l’hypertension artérielle
2016Doctorant·e : Léa Guyonnet
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
When YAP is hyperactivated in podocytes, it persistently “yaps,” disrupting the quiescence of neighboring glomerular cells
2026ArticleKidney International
Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death
2026ArticleJCI Insight
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice
2026ArticleProceedings of the National Academy of Sciences of the United States of America
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
2025ArticleBlood
Perturbation of the circadian clock in chronic diseases involving organ fibrosis
2025ArticleThe Journal of clinical investigation
Time course profiling of the kynurenine pathway activity in a pig model of crescentic glomerulonephritis
2025ArticleBMC Nephrology
Pathology-oriented multiplexing enables integrative disease mapping
2025ArticleNature
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
2025ArticleKidney International
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
101 RUE DE TOLBIAC 75654, 75013 PARIS 13E ARRONDISSEMENT
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Nature reviews. Nephrology · 2022
Science translational medicine · 2022
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators of this condition have remained elusive. We used a multi-omics analysis combined with artificial intelligence in a young patient cohort where major comorbidities were excluded at the onset. The cohort included 47 “critical” (in the intensive care unit under mechanical ventilation) and 25 “non-critical” (in a non-critical care ward) patients with COVID-19 and 22 healthy individuals. The analyses included whole-genome sequencing, whole-blood RNA sequencing, plasma and blood mononuclear cell proteomics, cytokine profiling, and high-throughput immunophenotyping. An ensemble of machine learning, deep learning, quantum annealing, and structural causal modeling were used. Patients with critical COVID-19 were characterized by exacerbated inflammation, perturbed lymphoid and myeloid compartments, increased coagulation, and viral cell biology. Among differentially expressed genes, we observed up-regulation of the metalloprotease ADAM9 . This gene signature was validated in a second independent cohort of 81 critical and 73 recovered patients with COVID-19 and was further confirmed at the transcriptional and protein level and by proteolytic activity. Ex vivo ADAM9 inhibition decreased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake and replication in human lung epithelial cells. In conclusion, within a young, otherwise healthy, cohort of individuals with COVID-19, we provide the landscape of biological perturbations in vivo where a unique gene signature differentiated critical from non-critical patients. We further identified ADAM9 as a driver of disease severity and a candidate therapeutic target.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Blood · 2026 · Journal Article
Breillat P, Magaziner SJ, Camus SM, Dionet L, et al.
Blood · 2025 · Journal Article
Breillat P, Carbone F, Lereclus E, Riller Q, et al.
Nature · 2025 · Journal Article
Kuehl M, Okabayashi Y, Wong MN, Gernhold L, et al.
Journal of hypertension · 2024 · Journal Article
Boulestreau R, Lorthioir A, Dreau H, Persu A, et al.
Journal of cellular physiology · 2024 · Journal Article
Andrique C, Bonnet AL, Dang J, Lesieur J, et al.
Nature communications · 2024 · Journal Article
Kosmider O, Possémé C, Templé M, Corneau A, et al.
Postgraduate medical journal · 2024 · Randomized Controlled Trial
Degrave R, Murris J, Charles-Nelson A, Hermine O, et al.
Journal of the American Society of Nephrology : JASN · 2023 · Journal Article
Salemkour Y, Yildiz D, Dionet L, 't Hart DC, et al.
British journal of haematology · 2023 · Journal Article
Ranque B, Diaw M, Dembele AK, Lapoumeroulie C, et al.
Clinical science (London, England : 1979) · 2023 · Journal Article
Dolade N, Rayego-Mateos S, Garcia-Carrasco A, Guerin M, et al.
Journal of hypertension · 2023 · Multicenter Study
Boulestreau R, Lorthioir A, Persu A, Sarafidis P, et al.
Science translational medicine · 2022 · Journal Article
Czopek A, Moorhouse R, Gallacher PJ, Pugh D, et al.
Nature reviews. Nephrology · 2022 · Journal Article
Mahtal N, Lenoir O, Tinel C, Anglicheau D, et al.
Kidney international · 2022 · Journal Article
Lenoir O, Tharaux PL
Journal of autoimmunity · 2022 · Journal Article
Melderis S, Warkotsch MT, Dang J, Hagenstein J, et al.
Science translational medicine · 2022 · Journal Article
Carapito R, Li R, Helms J, Carapito C, et al.
The Journal of clinical investigation · 2021 · Journal Article
Solagna F, Tezze C, Lindenmeyer MT, Lu S, et al.
Frontiers in medicine · 2021 · Journal Article
Mahtal N, Lenoir O, Tharaux PL
BMJ medicine · 2023 · Journal Article
Lacombe K, Hueso T, Porcher R, Mekinian A, et al.
The European respiratory journal · 2022 · Letter
Porcher R, Ravaud P, Resche-Rigon M, Tharaux PL, et al.
The European respiratory journal · 2022 · Journal Article
Hermine O, Mariette X, Porcher R, Resche-Rigon M, et al.
EClinicalMedicine · 2022 · Journal Article
Hermine O, Mariette X, Porcher R, Djossou F, et al.
JAMA internal medicine · 2021 · Letter
Mariette X, Hermine O, Tharaux PL, Resche-Rigon M, et al.
Journal of cellular and molecular medicine · 2022 · Journal Article
Siegerist F, Hay E, Dikou JS, Pollheimer M, et al.
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. The glomerular filtration b
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. The glomerular filtration b
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. The glomerular filtration b
Podocytes maintain high basal levels of autophagy independent of mtor signaling
While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates at the same time podocyte size and compensatory hypertrophy. Since MTO
Podocytes maintain high basal levels of autophagy independent of mtor signaling
While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates at the same time podocyte size and compensatory hypertrophy. Since MTO
A spatial signature of proximal tubules lipid metabolic switch during chronic kidney disease progression. IMS Experiments
IMS Experiments in .imzML format of the work: A spatial signature of proximal tubules lipid metabolic switch during chronic kidney disease progression
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).