📇 Rhumatologue · FALAISE · (14) · Libéral
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2 raisons identifiées
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
150.8 rhumatos / 100 000 hab. — département bien doté
13ans d'exercice (thèse 2013)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Direction : Hélène Elleaume, Jean-Luc Ravanat
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Contrast-enhanced synchrotron radiation therapy: From bench to bedside
2019Congrès16th International Congress for Radiation Research (ICRR2019)
Contrast‐enhanced synchrotron radiation therapy: From bench to bedside
2019CongrèsInternational conference on Radiation research Manchester ICRR 2019
Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy-enhancement
2017ArticleMedical Physics : The international journal of medical physics research and practice
Real-time detection of fast and thermal neutrons in radiotherapy with CMOS sensors
2017ArticlePhysics in Medicine and Biology
Nanoparticules et rayonnement synchrotron pour le traitement des tumeurs cérébrales
2013Thèse
Photo-activation therapy with high-Z nanoparticles: modelling at a micrometer level and experimental comparison
2012CongrèsGordon Research Seminar on Radiation Chemistry 2012
Radiothérapie par photoactivation de nanoparticules de Z élevé : modélisation Monte Carlo et comparaison expérimentale
2012Congrès51èmes Journées Scientifiques de la SFPM (JS-SFPM 2012)
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CABINET DU DR FLORENCE TAUPIN
8 RUE DE L ABBATIALE, 14700 FALAISE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Ouest-France · 29/03/2021
<a href="https://news.google.com/rss/articles/CBMi8gFBVV95cUxPekhmRlVHR0tYamQyTDNLa2hvbE9Odm5nODBhenBMeURmTTJiaHJFOG0wYUlneW82QXNaRHpJUjJ4TmxmeHBrV0NsbTFUdUxqWG9vZUZtSjFpZldqSGJyTGZ4MjNaT04tZjVubFRuakdlX1R2ZVZEeFFZaUFfOUpXTG5GRVFocks4TnBMeFFfQ3FwZWNtN1A4TWdUOUFzam5iVGRkSjVmdlBvdjJmcFVjT1UweWxfRDJuSE
📰 Ouest-France · 03/02/2020
<a href="https://news.google.com/rss/articles/CBMi9wFBVV95cUxNN1pJWkpnMGdURDdxMks2RE1sck5GUmlnbE1YQ25Pb0dzRkxDWmU5UVRXZXNvcW1GWHV0OVdlOVlkb1E3Y05pN202X0NyMHB1RjkxSS1lMjFkQVNzVGFaOXlDZW5PQ3VkRkZnMlhuYlMydldKWE5zQXNOQ180TkRaTFR6cnNnRDFQbVJBQVZHNVNCeDVfbHY2QTNTMXIwM2JYemUtMDZFSFhWUHlrc0xpOWM1Y0x1MmFNbU
Physics in medicine and biology · 2015
Medical physics · 2017
PurposeNanoparticles appear as a novel tool to enhance the effectiveness of radiotherapy in cancer treatments. Many parameters influence their efficacy, such as their size, concentration, composition, their cellular localization, as well as the photon source energy. The current Monte Carlo study aims at comparing the dose‐enhancement in presence of gadolinium (Gd), either as isolated atoms or atoms clustered in nanoparticles (NPs), by investigating the role played by these physical parameters at the cellular and the nanometer scale. In parallel, in vitro assays were performed in presence of either the gadolinium contrast agent (GdCA) Magnevist® or ultrasmall gadolinium NPs (GdNPs, 3 nm) for comparison with the simulations.MethodsPENELOPE Monte Carlo Code was used for in silico dose calculations. Monochromatic photon beams were used to calculate dose enhancements in different cell compartments and low‐energy secondary electron spectra dependence with energy. Particular attention has been placed on the interplay between the X‐ray beam energy, the Gd localization and its distance from cellular targets. Clonogenic assays were used to quantify F98 rat glioma cell survival after irradiation in the presence of GdNPs or GdCA, using monochromatic X‐rays with energies in the 30 keV–80 keV range from a synchrotron and 1.25 MeV gamma photons from a cobalt‐60 source. The simulations that correspond to the experimental conditions were compared with the experimental results.ResultsIn silico, a highly heterogeneous and clustered Gd‐atom distribution, a massive production of low energy electrons around GdNPs and an optimal X‐ray beam energy, above the Gd K‐edge, were key factors found to increase microscopic doses, which could potentially induce cell death. The different Gd localizations studied all resulted in a lower dose enhancement for the nucleus component than for cytoplasm or membrane compartments, with a maximum dose‐enhancement factor (DEF) found at 65 keV and 58 keV, respectively. In vitro, radiosensitization was observed with GdNPs incubated 5 h with the cells (2.1 mg Gd/mL) at all energies. Experimental DEFs were found to be greater than computational DEFs but follow a similar trend with irradiation energy. However, an important radiosensitivity was observed experimentally with GdNPs at high energy (1.25 MeV), whereas no effect was expected from modeling. This effect was correlated with GdNPs incubation time. In vitro, GdCA provided no dose enhancement at 1.25 MeV energies, in agreement with computed data.ConclusionsThese results provide a foundation on which to base optimizations of the physical parameters in Gd radiation‐enhanced therapy. Strong evidence was provided that GdCA or GdNPs could both be used for radiation dose‐enhancement therapy. There in vivo biological distribution, in the tumor volume and at the cellular scale, will be the key factor for providing large dose enhancements and determine their therapeutic efficacy.
Physics in medicine and biology · 2017
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Medical physics · 2017 · Comparative Study
Delorme R, Taupin F, Flaender M, Ravanat JL, et al.
Physics in medicine and biology · 2017 · Journal Article
Arbor N, Higueret S, Elazhar H, Combe R, et al.
Physics in medicine and biology · 2015 · Comparative Study
Taupin F, Flaender M, Delorme R, Brochard T, et al.