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6 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
29 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (5 thèses dirigées)
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Etude des réseaux bactériens autour des bactéries virulentes dans la carcinogenèse digestive
2025Doctorant·e : Mohammad Sadeghi
Etude de microbiote biliaire associé aux cholangiocarcinomes (CCA) et caractérisation des mécanismes impliqués
2021Doctorant·e : Massa Saab
Analyse de l'impact de Parvimonas micra sur les cellules coliques de l'hôte
2020Doctorant·e : Emma Bergsten
Etude de la contribution du microbiote intestinal et des facteurs environnementaux à la carcinogénèse colique
2016Doctorant·e : Aurélien Amiot
Rôle de la leptine dans le cancer colorectal humain
2008Doctorant·e : Nijez Aloulou
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
44
44 articles ont été cités au moins 44fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
8 075
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
213
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
79
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Université Paris-Est Créteil · Centre Hospitalier Universitaire Henri-Mondor · Assistance Publique – Hôpitaux de Paris
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1
2025ArticleBMJ Oncology
Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer
2025ArticleBiomedicines
Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis
2024ArticleMicroorganisms
The Colibactin-Producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance.
2024Congrès41 ème CECED
Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis
2024ArticleFrontiers in Oncology
Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes
2023ArticleGut microbes
Involvement of the NLRC5 / MHC class I axis in human colorectal cancer immune surveillance
2023CongrèsII Innate sensors & inflammation
OPERA: perception of information in patients with gastroenteropancreatic neuroendocrine tumors on lanreotide autogel
2023ArticleEuropean Journal of Endocrinology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
SERVICE DE SOINS PARIS GARE DE LYON
41 R DU CHAROLAIS, 75012 PARIS
GHU APHP HM SITE HENRI MONDOR
51 AV MAL DE LATTRE DE TASSIGNY, 94010 CRETEIL CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Le Monde.fr · 28/12/2022
<a href="https://news.google.com/rss/articles/CBMi2AJBVV95cUxQN1FIcVJDVFdwcnZ5bVQxM1lmN2UzR2UwempybXJyR05mb3ktRXBXS1NnX2VOSVA5cE1ENzU1MkFLODZPT3FyQ0h1MUFoSXFwVVgxdnI0SElXZHdwZ25LcnBmNTRvemo2U3Z6QXRFMW5NUUktTW1ZdlJ2bk02bFh1UXFvYU1MdHkxaU9ha0hNRFJ5TGs0eC1NdWtRUjJWdDdLOW9tTzFrNUxZbmtXSDg4R2hyb0psRy1HeV
Proceedings of the National Academy of Sciences of the United States of America · 2019
Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and its environment. Environmental stressors act by causing host cell DNA alterations implicated in the onset of cancer. Here we investigate the stressor ability of CRC-associated gut dysbiosis as causal agent of host DNA alterations. The epigenetic nature of these alterations was investigated in humans and in mice. Germ-free mice receiving fecal samples from subjects with normal colonoscopy or from CRC patients were monitored for 7 or 14 wk. Aberrant crypt foci, luminal microbiota, and DNA alterations (colonic exome sequencing and methylation patterns) were monitored following human feces transfer. CRC-associated microbiota induced higher numbers of hypermethylated genes in murine colonic mucosa (vs. healthy controls’ microbiota recipients). Several gene promoters including SFRP1,2,3, PENK, NPY, ALX4, SEPT9, and WIF1 promoters were found hypermethylated in CRC but not in normal tissues or effluents from fecal donors. In a pilot study ( n = 266), the blood methylation levels of 3 genes ( Wif1 , PENK , and NPY ) were shown closely associated with CRC dysbiosis. In a validation study ( n = 1,000), the cumulative methylation index (CMI) of these genes was significantly higher in CRCs than in controls. Further, CMI appeared as an independent risk factor for CRC diagnosis as shown by multivariate analysis that included fecal immunochemical blood test. Consequently, fecal bacterial species in individuals with higher CMI in blood were identified by whole metagenomic analysis. Thus, CRC-related dysbiosis induces methylation of host genes, and corresponding CMIs together with associated bacteria are potential biomarkers for CRC.
Clinical chemistry · 2016
AbstractBACKGROUNDCirculating tumor DNA (ctDNA) has emerged as a good candidate for tracking tumor dynamics in different cancer types, potentially avoiding repeated tumor biopsies. Many different genes can be mutated within a tumor, complicating procedures for tumor monitoring, even with highly sensitive next-generation sequencing (NGS) strategies. Droplet-based digital PCR (dPCR) is a highly sensitive and quantitative procedure, allowing detection of very low amounts of circulating tumor genetic material, but can be limited in the total number of target loci monitored.METHODSWe analyzed hypermethylation of 3 genes, by use of droplet-based dPCR in different stages of colorectal cancer (CRC), to identify universal markers for tumor follow-up.RESULTSHypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage. All tumor tissues appeared positive for one of the 2 markers. Methylated ctDNA (MetctDNA) was detected in 80% of metastatic CRC and 45% of localized CRC. For samples with detectable mutations in ctDNA, MetctDNA and mutant ctDNA (MutctDNA) fractions were correlated. During follow-up of different stage CRC patients, MetctDNA changes allowed monitoring of tumor evolution.CONCLUSIONSThese results indicate that MetctDNA could be used as a universal surrogate marker for tumor follow-up in CRC patients, and monitoring MetctDNA by droplet-based dPCR could avoid the need for monitoring mutations.
PloS one · 2021
Extrahepatic cholangiocarcinoma (CCA) accounts for 3% of digestive cancers. The role of biliary microbiota as an environment-related modulator has been scarcely investigated in CCA, and the putative impact of associated diseases has not been yet assessed. We characterized the biliary microbiota in CCA patients in order to identify a specific CCA-related dysbiosis. The biliary effluents were collected through an endoscopic retrograde pancreatic cholangiography (ERCP) examination involving 28 CCA and 47 patients with gallstones, herein considered as controls. The biliary effluents were submitted to bacterial DNA extraction and 16S rRNA sequencing, using Illumina technology. Overall, 32% of CCA and 22% of controls displayed another associated disease, such as diabetes, pancreatitis, inflammatory bowel disease, or primary sclerosing cholangitis. Such associated diseases were considered in the comparisons that were made. Principal coordinate analysis (PCoA) detected a significant disparity of biliary microbiota composition between CCA patients and controls without an associated disease. Amongst the most abundant phyla,Proteobacteriadid not significantly differ between CCA patients and controls, whereasFirmicuteslevels were lower andBacteroideteshigher in CCAs’ biliary microbiota than in the controls’ microbiota. The most abundant genera wereEnterococcus,Streptococcus,Bacteroides,Klebsiella, andPyramidobacter in CCA’s biliary microbiota. Additionally, levels ofBacteroides,Geobacillus,Meiothermus, andAnoxybacillusgenera were significantly higher in CCA patients’ biliary microbiota, without an associated disease, in comparison with controls. A specific CCA-related dysbiosis was identified as compared to controls independently from associated diseases. This suggests that a microorganism community may be involved in CCA pathogenesis.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Clinics and research in hepatology and gastroenterology · 2024 · Journal Article
Martin A, Jauvain M, Bergsten E, Demontant V, et al.
Sleep & breathing = Schlaf & Atmung · 2023 · Systematic Review
Bianchi G, de'Angelis N, Gavriilidis P, Sobhani I, et al.
Microorganisms · 2021 · Journal Article
Lauka L, Sobhani I, Brunetti F, Mestivier D, et al.
PloS one · 2021 · Journal Article
Saab M, Mestivier D, Sohrabi M, Rodriguez C, et al.
Microorganisms · 2020 · Journal Article
Bergsten E, Mestivier D, Sobhani I
World journal of surgical oncology · 2019 · Journal Article
Lauka L, Reitano E, Carra MC, Gaiani F, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2019 · Journal Article
Sobhani I, Bergsten E, Couffin S, Amiot A, et al.
Frontiers in oncology · 2023 · Journal Article
Sadeghi M, Mestivier D, Carbonnelle E, Benamouzig R, et al.
Clinics and research in hepatology and gastroenterology · 2023 · Journal Article
Uzzan M, Assouline V, Chambenois E, Djabbari M, et al.
Journal of clinical medicine · 2023 · Journal Article
Becq A, Laurent A, De Roux Q, Cremone C, et al.
Sleep & breathing = Schlaf & Atmung · 2023 · Systematic Review
Bianchi G, de'Angelis N, Gavriilidis P, Sobhani I, et al.
Frontiers in surgery · 2022 · Journal Article
Bianchi G, Gavriilidis P, Martínez-Pérez A, de'Angelis GL, et al.
Bulletin du cancer · 2018 · Journal Article
Jmour O, Pellat A, Colson-Durand L, To NH, et al.
Sleep & breathing = Schlaf & Atmung · 2023 · Systematic Review
Bianchi G, de'Angelis N, Gavriilidis P, Sobhani I, et al.
Frontiers in surgery · 2022 · Journal Article
Bianchi G, Gavriilidis P, Martínez-Pérez A, de'Angelis GL, et al.
Therapeutic advances in medical oncology · 2024 · Journal Article
Hammel P, Smith D, Afchain P, Dominguez-Tinajero S, et al.
The Lancet. Oncology · 2023 · Randomized Controlled Trial
Walter T, Lievre A, Coriat R, Malka D, et al.
European journal of cancer (Oxford, England : 1990) · 2017 · Clinical Trial, Phase III
Alimentary pharmacology & therapeutics · 2021 · Journal Article
Trystram N, Abitbol V, Tannoury J, Lecomte M, et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2019 · Journal Article
Petitdidier N, Tannoury J, de'Angelis N, Gagniere C, et al.
Leukemia & lymphoma · 2022 · Observational Study
Lévy M, Dupuis J, Charpy C, Martin A, et al.
Clinical lymphoma, myeloma & leukemia · 2021 · Journal Article
Rotkopf H, Lévy M, Copie-Bergman C, Dupuis J, et al.
Clinics and research in hepatology and gastroenterology · 2025 · Journal Article
Kirchgesner J, Augustin J, Bazin T, Freiha P, et al.
Endoscopy international open · 2017 · Journal Article
Cremone C, Esch A, Gagniere C, Fugazza A, et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A · 2018 · Comparative Study
de'Angelis N, Abdalla S, Bianchi G, Memeo R, et al.
European journal of cancer (Oxford, England : 1990) · 2017 · Clinical Trial, Phase III
Aparicio T, Gargot D, Teillet L, Maillard E, et al.
Clinical chemistry · 2016 · Journal Article
Garrigou S, Perkins G, Garlan F, Normand C, et al.
Leukemia & lymphoma · 2020 · Journal Article
Tannoury J, Amiot A, Lemonnier F, Dupuis J, et al.
Sleep & breathing = Schlaf & Atmung · 2023 · Systematic Review
Bianchi G, de'Angelis N, Gavriilidis P, Sobhani I, et al.
2017 WSES guidelines for the management of iatrogenic colonoscopy perforation
Abstract Iatrogenic colonoscopy perforation (ICP) is a severe complication that can occur during both diagnostic and therapeutic procedures. Although 45–60% of ICPs are diagnosed by the endoscopist while performing the c
Additional file 2 of 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
Additional file 2.
Additional file 1 of 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
Additional file 1.
2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
Abstract Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estima
Additional file 2 of 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
Additional file 2.
2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
Abstract Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estima
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Frontiers in cellular and infection microbiology · 2022 · Journal Article
Périchon B, Lichtl-Häfele J, Bergsten E, Delage V, et al.
Frontiers in cellular and infection microbiology · 2021 · Journal Article
Sobhani I, Bergsten E, Charpy C, Chamaillard M, et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2018 · Journal Article
Rentien AL, Lévy M, Copie-Bergman C, Gagniere C, et al.
Transplant international : official journal of the European Society for Organ Transplantation · 2018 · Journal Article
Landi F, de'Angelis N, Sepulveda A, Martínez-Pérez A, et al.
World journal of emergency surgery : WJES · 2017 · Journal Article
Martínez-Pérez A, de'Angelis N, Brunetti F, Le Baleur Y, et al.
Transplant international : official journal of the European Society for Organ Transplantation · 2018 · Journal Article
Landi F, de'Angelis N, Sepulveda A, Martínez-Pérez A, et al.
World journal of emergency surgery : WJES · 2017 · Journal Article
Martínez-Pérez A, de'Angelis N, Brunetti F, Le Baleur Y, et al.
Aparicio T, Gargot D, Teillet L, Maillard E, et al.