📇 Rhumatologue · FEROLLES ATTILLY · (77) · Salarié

M Gérald SIMONNEAU

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Auteur de référence en rhumatologie
33 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
65.4 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 FEROLLES ATTILLY (77)SalariéRPPS 10000958412

📊 Reconnaissance scientifique : 151/100📝 934 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

The European respiratory journal · 2023

📚 1386 citations🎯 RCR 227.96Top 0% NIH🔓 Open Access📄 PDF gratuit ↗

Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (RACE): a multicentre, phase 3, open-label, randomised controlled trial and ancillary follow-up study

The Lancet. Respiratory medicine · 2022

📚 173 citations🎯 RCR 18.81Top 1% NIH🩺 Clinique

Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension

American journal of respiratory and critical care medicine · 2021

📚 161 citations🎯 RCR 11.99Top 2% NIH🔓 Open Access

Lire l'abstract Crossref ↓

Abstract Rationale The relationship between the initial treatment strategy and survival in pulmonary arterial hypertension (PAH) remains uncertain. Objectives To evaluate the long-term survival of patients with PAH categorized according to the initial treatment strategy. Methods A retrospective analysis of incident patients with idiopathic, heritable, or anorexigen-induced PAH enrolled in the French Pulmonary Hypertension Registry (January 2006 to December 2018) was conducted. Survival was assessed according to the initial strategy: monotherapy, dual therapy, or triple-combination therapy (two oral medications and a parenteral prostacyclin). Measurements and Main Results Among 1,611 enrolled patients, 984 were initiated on monotherapy, 551 were initiated on dual therapy, and 76 were initiated on triple therapy. The triple-combination group was younger and had fewer comorbidities but had a higher mortality risk. The survival rate was higher with the use of triple therapy (91% at 5 yr) as compared with dual therapy or monotherapy (both 61% at 5 yr) (P &lt; 0.001). Propensity score matching of age, sex, and pulmonary vascular resistance also showed significant differences between triple therapy and dual therapy (10-yr survival, 85% vs. 65%). In high-risk patients (n = 243), the survival rate was higher with triple therapy than with monotherapy or dual therapy, whereas there was no difference between monotherapy and double therapy. In intermediate-risk patients (n = 1,134), survival improved with an increasing number of therapies. In multivariable Cox regression, triple therapy was independently associated with a lower risk of death (hazard ratio, 0.29; 95% confidence interval, 0.11–0.80; P = 0.017). Among the 148 patients initiated on a parenteral prostacyclin, those on triple therapy had a higher survival rate than those on monotherapy or dual therapy. Conclusions Initial triple-combination therapy that includes parenteral prostacyclin seems to be associated with a higher survival rate in PAH, particularly in the youngest high-risk patients.

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M Gérald SIMONNEAU

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (33) — classées par pathologie

Transversal16

Épidémiologie & registres6

Essai clinique5

Pharmacovigilance3

Revue générale2

Biomarqueurs / Auto-Ac1

csDMARDs1

Recommandations1

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