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3 raisons identifiées
Auteur de référence en rhumatologie
35 articles scientifiques publiés — un praticien à la pointe de la recherche
Disponibilité géographique
4 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
86.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR AMIR SHARIFI
13 RUE PASTEUR, 78370 PLAISIR
CENTRE HOSPITALIER DE PLAISIR
220 R MANSART BP 19, 78375 PLAISIR CEDEX
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
CENTRE SPECIALISE GILBERT RABY
2 AV DU MARECHAL JOFFRE, 78250 MEULAN EN YVELINES
CABINET DU DR AMIR SHARIFI
13 RUE TELLIER FRERES, 78750 MAREIL MARLY
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Cells, tissues, organs · 2017
<b><i>Aims:</i></b> The protective effects of ginger (<i>Zingiber officinale</i> Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis were investigated in C28I2 human chondrocytes. <b><i>Methods:</i></b> The effects of various concentrations of ginger extract on C28I2 human chondrocyte viability were evaluated in order to obtain noncytotoxic concentrations of the drug by methylthiotetrazole assay. The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h. The effects of ginger extract on IL-1β-induced intracellular reactive oxygen species (ROS) production and lipid peroxidation were examined. The mRNA expressions of antioxidant enzymes including catalase, superoxide dismutase-1, glutathione peroxidase-1, glutathione peroxidase-3, and glutathione peroxidase-4 were evaluated by reverse transcription polymerase chain reaction. The protein expressions of Bax, Bcl-2, and caspase-3 were analyzed by Western blotting. <b><i>Results:</i></b> No cytotoxicity was observed at any concentration of ginger extract in C28I2 cells. Ginger extract pretreatment remarkably increased the gene expression of antioxidant enzymes and reduced the IL-1β-induced elevation of ROS, lipid peroxidation, the Bax/Bcl-2 ratio, and caspase-3 activity. <b><i>Conclusions:</i></b> Ginger extract could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis as the major mechanisms of chondrocyte cell death. These beneficial effects of ginger extract may be due to its antioxidant properties. It may be considered as a natural herbal product to prevent OA-induced cartilage destruction in the clinical setting.
Clinical and experimental pharmacology & physiology · 2016
SummarySimvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. Severalin vivostudies evaluated its role on osteoporosis and fracture healing, however, controversial results are seen in the literature. For this reason, Simvastatin has not been the focus of any clinical trials as yet. This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses onin vivoinvestigations that have evaluated its role on osteoporosis and fracture repair to find out (i) whether Simvastatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. Simvastatin induces osteoinduction by increasing osteoblast activity and differentiation and inhibiting their apoptosis. It also reduces osteoclastogenesis by decreasing both the number and activity of osteoclasts and their differentiation. Controversial results between thein vivostudies are mostly due to the differences in the route of administration, dose, dosage and carrier type. Local delivery of Simvastatin through controlled drug delivery systems with much lower doses and dosages than the systemic route seems to be the most valuable option in fracture healing. However, systemic delivery of Simvastatin with much higher doses and dosages than the clinical ones seems to be effective in managing osteoporosis. Simvastatin, in a particular range of doses and dosages, may be beneficial in managing osteoporosis and fracture injuries. This review showed that Simvastatin is effective in the treatment of osteoporosis and fracture healing.
Journal of cellular biochemistry · 2017
ABSTRACTThe protective effects and mechanisms of DADS on IL‐1β‐mediated oxidative stress and mitochondrial apoptosis were investigated in C28I2 human chondrocytes. The effect of various concentrations of DADS (1, 5 10, 25, 50, and 100 μM) on C28I2 cell viability was evaluated in different times (2, 4, 8, 16, and 24 h) to obtain the non‐cytotoxic concentrations of drug by MTT‐assay. The protective effect of non‐toxic concentrations of DADS on experimentally induced oxidative stress and apoptosis by IL‐1β in C28I2 was evaluated. The effects of DADS on IL‐1β‐induced intracellular ROS production and lipid peroxidation were detected and the proteins expression of Nrf2, Bax, Bcl‐2, caspase‐3, total and phosphorylated JNK, and P38 MAPKs were analyzed by Western blotting. The mRNA expression of detoxifying phase II/antioxidant enzymes including heme oxygenase‐1, NAD(P)H quinine oxidoreductase, glutathione S‐transferase‐P1, catalase, superoxide dismutase‐1, glutathione peroxidase‐1, ‐3, ‐4 were evaluated by reverse transcription‐polymerase chain reaction. DADS in 1, 5, 10, and 25 μM concentrations had no cytotoxic effect after 24 h. Pretreatment with DADS remarkably increased Nrf2 nuclear translocation as well as the genes expression of detoxifying phase II/antioxidant enzymes and reduced IL‐1β‐induced elevation of ROS, lipid peroxidation, Bax/Bcl‐2 ratio, caspase‐3 activation, and JNK and P38 phosphorylation. DADS could considerably reduce IL‐1β‐induced oxidative stress and consequent mitochondrial apoptosis, as the major mechanisms of chondrocyte cell death in an experimental model of osteoarthritis. It may be considered as natural product in protecting OA‐induced cartilage damage in clinical setting. J. Cell. Biochem. 118: 1879–1888, 2017. © 2017 Wiley Periodicals, Inc.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
ACS sensors · 2024 · Journal Article
Sharifi AR, Mazzaracchio V, Duranti L, Gullo L, et al.
ACS sensors · 2024 · Journal Article
Golmohammadi H, Parnianchi F, Sharifi AR, Naghdi T, et al.
Analytical chemistry · 2023 · Journal Article
Sharifi AR, Ardalan S, Tabatabaee RS, Soleimani Gorgani S, et al.
Biosensors & bioelectronics · 2023 · Journal Article
Naghdi T, Ardalan S, Asghari Adib Z, Sharifi AR, et al.
Genes · 2021 · Journal Article
Jansen S, Baulain U, Habig C, Ramzan F, et al.
Tanaffos · 2020 · Journal Article
Rezaeifar P, Nouri-Vaskeh M, Nazemiyeh M, Dorraji A, et al.
Animals : an open access journal from MDPI · 2020 · Journal Article
Jansen S, Bues M, Baulain U, Habig C, et al.
Animals : an open access journal from MDPI · 2020 · Journal Article
Jansen S, Baulain U, Habig C, Weigend A, et al.
Journal of physiology and biochemistry · 2019 · Journal Article
Hosseinzadeh A, Bahrampour Juybari K, Kamarul T, Sharifi AM
Journal of receptor and signal transduction research · 2019 · Journal Article
Juybari KB, Hosseinzadeh A, Sharifi AM
Cell and tissue research · 2018 · Journal Article
Bahrampour Juybari K, Kamarul T, Najafi M, Jafari D, et al.
Cellular and molecular biology (Noisy-le-Grand, France) · 2018 · Journal Article
Nazemian V, Manaheji H, Sharifi AM, Zaringhalam J
Journal of cellular biochemistry · 2017 · Journal Article
Hosseinzadeh A, Jafari D, Kamarul T, Bagheri A, et al.
Journal of clinical and diagnostic research : JCDR · 2017 · Journal Article
Soleimani A, Mobedi Z, Al-E-Rasul M, Sharifi A, et al.
Cells, tissues, organs · 2017 · Journal Article
Hosseinzadeh A, Bahrampour Juybari K, Fatemi MJ, Kamarul T, et al.
Human immunology · 2015 · Comparative Study
Khorrami S, Mohammadpour H, Shahzamani K, Zarif MN, et al.
Annals of translational medicine · 2015 · Journal Article
Siavoshi F, Saniee P, Khalili-Samani S, Hosseini F, et al.
Middle East journal of digestive diseases · 2013 · Journal Article
Zamani H, Barzin G, Yousefinia M, Mohammadkhani A, et al.
Middle East journal of digestive diseases · 2012 · Case Reports
Sharifi AH, Fakharzadeh E, Zamini H, Haj-Sheykholeslami A, et al.
Archives of Iranian medicine · 2011 · Case Reports
Jabbari H, Fakharzadeh E, Merat S, Zamini H, et al.
Toxicology mechanisms and methods · 2011 · Journal Article
Sharifi AM, Ghazanfari R, Tekiyehmaroof N, Sharifi MA
Therapeutic advances in musculoskeletal disease · 2024 · Journal Article
Aziz A, Ganesan Nathan K, Kamarul T, Mobasheri A, et al.
Radiographics : a review publication of the Radiological Society of North America, Inc · 2020 · Journal Article
Sharifi A, Siebert MJ, Chhabra A
Clinical and experimental pharmacology & physiology · 2016 · Journal Article
Moshiri A, Sharifi AM, Oryan A
The Journal of international medical research · 2024 · Case Reports
Sharifzadeh Kermani M, Farsi M, Sharifi A, Sardarinia M, et al.
Middle East journal of digestive diseases · 2016 · Journal Article
Mirminachi B, Farrokhzad S, Sharifi AH, Nikfam S, et al.
Archives of Iranian medicine · 2017 · Journal Article
Naderian M, Kolahdoozan S, Sharifi AS, Garmaroudi G, et al.
Addiction & health · 2010 · Journal Article
Ziaaddini H, Sharifi A, Nakhaee N, Ziaaddini A
Therapeutic advances in musculoskeletal disease · 2024 · Journal Article
Aziz A, Ganesan Nathan K, Kamarul T, Mobasheri A, et al.
Clinical and experimental pharmacology & physiology · 2016 · Journal Article
Moshiri A, Sharifi AM, Oryan A
Skeletal radiology · 2020 · Published Erratum
Siebert MJ, Chalian M, Sharifi A, Pezeshk P, et al.
Skeletal radiology · 2020 · Journal Article
Siebert MJ, Chalian M, Sharifi A, Pezeshk P, et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021 · Case Reports
Zojaji M, Abkhoo A, Naderi A, Sharifi A, et al.
Middle East journal of digestive diseases · 2014 · Journal Article
Sharifi AH, Mohammadi M, Fakharzadeh E, Zamini H, et al.
Computer methods in biomechanics and biomedical engineering · 2021 · Journal Article
Sharifi A, Ahmadi M, Mehni MA, Jafarzadeh Ghoushchi S, et al.
Archives of Iranian medicine · 2010 · Comparative Study
Jabbari H, Bayatian A, Sharifi AH, Zaer-Rezaee H, et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021 · Journal Article
Moradi S, Shokraee K, Sharifi A, Zojaji M, et al.
A Deep Learning based Hazardous Materials (HAZMAT) Sign Detection Method with Restricted Computational Resources
This is the publicly available code for the following publication: Amir Sharifi, Ahmadreza Zibaei, Mahdi Rezaei (2021). A Deep Learning based Hazardous Materials (HAZMAT) Sign Detection Robot with Restricted Computationa
DeepHAZMAT: Hazardous Materials Sign Detection and Segmentation with Restricted Computational Resources
One of the most challenging and non-trivial tasks in robot-based rescue operations is the Hazardous Materials or HAZMATs sign detection in the operation field, to prevent further unexpected disasters. Each Hazmat sign ha
A Deep Learning based Hazardous Materials (HAZMAT) Sign Detection Method with Restricted Computational Resources
This is the publicly available code for the following publication: Amir Sharifi, Ahmadreza Zibaei, Mahdi Rezaei (2021). A Deep Learning based Hazardous Materials (HAZMAT) Sign Detection Robot with Restricted Computationa
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Middle East journal of digestive diseases · 2016 · Journal Article
Mirminachi B, Farrokhzad S, Sharifi AH, Nikfam S, et al.
✨ Profil synthétique
IA · 19/05/2026Le Dr Amir Sharifi est un rhumatologue exerçant à Plaisir. Ses recherches portent principalement sur les maladies du foie et les infections gastroentestinales, avec un h-index de 10 et 18 publications. Ses travaux publiés sur PubMed couvrent diverses pathologies, notamment les tendinopathies et les thérapies anti-TNF.
Expertises présumées
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.