MME Marie-Helene SAUVAJON-CARPENTIER

Rhumatologue

📍 ARGENCES (14)LibéralRPPS 10002109246

✨ Profil synthétique

IA · 19/05/2026

MME Marie-Helene SAUVAJON-CARPENTIER est une rhumatologue exerçant à ARGENCES. Ses publications sur PubMed couvrent diverses pathologies et thématiques, notamment l'arthrite juvénile, les vascularites des gros vaisseaux et l'économie de santé. Elle a également publié sur les traitements tels que les csDMARDs et les anti-IL-17.

Expertises présumées

Arthrite juvénile
Vascularites des gros vaisseaux
Traitement par csDMARDs
Thérapeutique anti-IL-17
Épidémiologie en rhumatologie
Économie de la santé
Recherche en registres de maladies

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

✨ Génération du profil synthétique IA en cours…

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Remplaçant
CABINET DU DR Marie-Helene SAUVAJON-CARPENTIER
CABINET MEDICAL 11 BOULEVARD DELEAN, 14370 ARGENCES
☎ 0231236012Activité de soin et de pharmacie

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease

Cell reports · 2021

📚 173 citations🎯 RCR 11.05Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

Molecular psychiatry · 2020

📚 142 citations🎯 RCR 8.28Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

International journal of molecular sciences · 2020

📚 27 citations🎯 RCR 1.46🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD-related synaptic and memory dysfunctions when treatment started in juvenile animals long before onset of disease symptoms, while a pharmacological treatment that can reverse synaptic and memory deficits in AD mice was thus far not identified. Repurposing food and drug administration (FDA)-approved drugs for treatment of AD is a promising way to reduce the time to bring such medication into clinical practice. The sphingosine-1 phosphate analog fingolimod (FTY720) was approved recently for treatment of multiple sclerosis patients. Here, we addressed whether fingolimod rescues AD-related synaptic deficits and memory dysfunction in an amyloid precursor protein/presenilin-1 (APP/PS1) AD mouse model when medication starts after onset of symptoms (at five months). Male mice received intraperitoneal injections of fingolimod for one to two months starting at five to six months. This treatment rescued spine density as well as long-term potentiation in hippocampal cornu ammonis-1 (CA1) pyramidal neurons, that were both impaired in untreated APP/PS1 animals at six to seven months of age. Immunohistochemical analysis with markers of microgliosis (ionized calcium-binding adapter molecule 1; Iba1) and astrogliosis (glial fibrillary acid protein; GFAP) revealed that our fingolimod treatment regime strongly down regulated neuroinflammation in the hippocampus and neocortex of this AD model. These effects were accompanied by a moderate reduction of Aβ accumulation in hippocampus and neocortex. Our results suggest that fingolimod, when applied after onset of disease symptoms in an APP/PS1 mouse model, rescues synaptic pathology that is believed to underlie memory deficits in AD mice, and that this beneficial effect is mediated via anti-neuroinflammatory actions of the drug on microglia and astrocytes.

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MME Marie-Helene SAUVAJON-CARPENTIER

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal31

Arthrite juvénile2

Vascularites des gros vaisseaux2

Anti-IL-171

csDMARDs1

Économie santé1

Épidémiologie & registres1

Essai clinique1

Génétique1

JAK inhibiteurs1

Lombalgie1

Lupus1

Maladie à IgG41

Qualité de vie / PROMs1

Revue générale1

Sjögren1

Vascularites1

Vraie vie / RWE1

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