📇 Rhumatologue · VITRY SUR SEINE · (94) · Salarié
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2 raisons identifiées
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
134 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
2
2 articles ont été cités au moins 2fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
332
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
4
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
2
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Bicêtre Hospital
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
MS MEDICAL
HOPITAL PRIVE DE VITRY 22 RUE DE LA PETITE SAUSSAIE, 94400 VITRY SUR SEINE
MS MEDICAL
2 RUE ANTOINE DE SAINT EXUPERY, 94310 ORLY
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
American journal of respiratory and critical care medicine · 2009
Abstract Rationale Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging. Objectives To test the hypothesis that patients with COPD experience accelerated telomere shortening and that inflammation is linked to this process. Methods We measured telomere length, using a quantitative polymerase chain reaction–based method, and plasma levels of various cytokines in 136 patients with COPD, 113 age- and sex-matched smokers, and 42 nonsmokers with normal lung function. Measurements and Main Results Median (range) telomere length ratio was significantly lower in patients with COPD (0.57 [0.23–1.18]) than in control smokers (0.79 [0.34–1.58]) or nonsmokers (0.85 [0.38–1.55]) (P < 0.001). The difference remained highly significant when using logistic regression analysis adjusted for age, sex, and tobacco exposure. Both females and males with COPD had shorter telomere length than same-sex control subjects. Telomere length was related to age in patients and control subjects but was shorter in patients than in control subjects in all age groups. No relationship was found between telomere length and tobacco exposure in patients or control subjects, with no difference between control smokers and nonsmokers. In patients with COPD, telomere length was related to PaO2 (P < 0.001) and PaCO2 (P < 0.001) but not to lung function parameters or the BODE Index. Patients with COPD also had elevated plasma levels of various cytokines, interleukin-6 correlating negatively with telomere length (P < 0.001). Conclusions Given that in vivo telomere length reflects cellular turnover and exposure to oxidative and inflammatory damage, our data support accelerated aging in COPD.
Critical care medicine · 2011
Objectives: The level of pressure-support ventilation can affect mean airway pressure and potentially lung volume, but its increase is usually associated with a reduced respiratory rate, and the net effects on the gas exchange process and its components, including end-expiratory lung volume, have not been carefully studied. We measured pulmonary conductance for gas exchange based on lung diffusion for carbon monoxide in patients receiving pressure-support ventilation. Design: Prospective, randomized, crossover study. Setting: Medical intensive care unit of a university hospital. Patients: Sixteen patients mechanically ventilated in pressure-support ventilation mode and free from chronic obstructive pulmonary disease. Interventions: Two pressure-support ventilation levels (5 cm H2O difference) at the same level of positive end-expiratory pressure. Measurements and Main Results: End-expiratory lung volume, lung diffusion for carbon monoxide, and SpO2/Fio2 were evaluated. Increasing pressure-support ventilation by 5 cm H2O significantly increased the mean tidal volume from 6.8 to 8.5 mL/kg of predicted body weight and decreased the mean respiratory rate by 6.6 breaths per minute. Although SpO2/Fio2 did not change significantly, there was a slight but significant decrease in lung diffusion for carbon monoxide (average decay rate of 4.5%) at high pressure-support ventilation. The pressure-support ventilation level did not significantly affect end-expiratory lung volume (1737 ± 629 mL at 9.6 ± 2.5 cm H2O pressure-support ventilation level vs. 1749 ± 657 mL at 14.9 ± 2.1 cm H2O pressure-support ventilation level). Conclusions: A 5-cm H2O increase in pressure-support ventilation neither affected end-expiratory lung volume nor increased the pulmonary volume participating in gas exchange. A target tidal volume closer to 6 mL/kg of predicted body weight than to 8 mL/kg during pressure-support ventilation was associated with better gas exchange.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Critical care medicine · 2011 · Journal Article
Pinto Da Costa N, Di Marco F, Lyazidi A, Carteaux G, et al.
American journal of respiratory and critical care medicine · 2009 · Journal Article
Savale L, Chaouat A, Bastuji-Garin S, Marcos E, et al.