📇 Rhumatologue · BERNAY · (27) · Hospitalier
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3 raisons identifiées
Praticien-chercheur
5 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
63.9 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR CHRISTOPHER SANDIN
11 RUE ALBERT GLATIGNY, 27300 BERNAY
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Actu.fr · 14/02/2020
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📰 Actu.fr · 30/03/2020
<a href="https://news.google.com/rss/articles/CBMi2gFBVV95cUxOVXo2ckpRUDZQazlFelp5dlBObXo4RDdhWjNzemhUdjVXYXlWRzMwSngxMjdlRVNKNmpuT3A3dGhSdnhhVmxQY1d0dHJqR1N1ZGprSGoxaGE1a180OERJdDZnek9FekNKNUdVbGxLUXlwakRXRjYyVVgxR2Z2bEtFZVRsOU9UaGxYUVNfekJBTE1ieVdxUW9tRnNWSXlmc0dwN1FtR2dzTG1jdFd4MmxqVE9EZjNaV0ZKdD
Arthritis & rheumatology (Hoboken, N.J.) · 2014
ObjectiveRheumatoid arthritis (RA) is thought to be a T cell–mediated disease, based on its strong association with HLA class II alleles, clinical responsiveness to T cell–directed therapies, and the presence of CD4+ T cells in rheumatoid joints. The presence of anti–citrullinated protein antibodies (ACPAs) in RA serum and the association of these antibodies with HLA–DR4 alleles implicate citrulline‐specific autoreactive T cells in the development and progression of RA. The goal of this study was to determine the characteristics and specificity of autoreactive T cell responses in RA.MethodsWe developed a panel of HLA–DRB1*04:01 tetramers, selecting citrullinated peptides from synovial antigens and verifying their immunogenicity in DRB1*04:01‐transgenic mice. Seven tetramers were used to examine the ex vivo frequency and surface phenotype of citrulline‐specific (Cit‐specific) T cells in patients with RA and healthy subjects with DRB1*04:01 haplotypes, using a magnetic enrichment procedure.ResultsCit‐specific T cells were detectable in peripheral blood samples from both healthy subjects and RA patients. In comparison to healthy subjects, RA patients had significantly higher frequencies of Cit‐specific T cells, and a greater proportion of these cells displayed a Th1 memory phenotype. Among RA patients, the frequency of Cit‐specific T cells was highest within the first 5 years after diagnosis of RA and was decreased in patients taking biologic agents, irrespective of disease duration.ConclusionThese findings link the presence of ACPAs in RA with Th1 cells specific for citrullinated epitopes and provide tools for disease‐specific immunomonitoring of autoreactive T cells.
Clinical and experimental immunology · 2016
SummaryCirculating immunoglobulin (Ig)A class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement. However, secretory IgA (SIgA) PR3-ANCA has not been reported previously. In this study we compared serum levels of SIgA PR3-ANCA and IgA PR3-ANCA with IgG PR3-ANCA in relation to disease characteristics. Among 73 patients with AAV and PR3-ANCA at diagnosis, 84% tested positive for IgG PR3-ANCA, 47% for IgA-ANCA and 36% for SIgA PR3-ANCA at the time of sampling for the present study. IgA and IgG PR3-ANCA were represented similarly among patients with different organ manifestations, i.e. upper airway, lung or kidney at time of sampling. However, SIgA PR3-ANCA was significantly less represented among patients with upper airway involvement. During active disease, the proportions of IgA PR3-ANCA and SIgA PR3-ANCA-positive patients were significantly higher compared to inactive disease. Eight patients were sampled prospectively during 24 months from onset of active disease. In these patients, IgA PR3-ANCA and SIgA PR3-ANCA turned negative more often after remission induction compared to IgG PR3-ANCA. Our findings suggest that serum IgA PR3-ANCA and SIgA PR3-ANCA are related more closely to disease activity in AAV compared to IgG PR3-ANCA. Further studies are required to reveal if this has implications for disease activity monitoring. The mean number of PR3-ANCA isotypes increased along with disease activity, suggesting a global B cell activation during active disease.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Frontiers in immunology · 2017 · Journal Article
Gerstner C, Dubnovitsky A, Sandin C, Kozhukh G, et al.
Frontiers in immunology · 2016 · Journal Article
Gerstner C, Dubnovitsky A, Sandin C, Kozhukh G, et al.
PloS one · 2014 · Journal Article
Abugessaisa I, Saevarsdottir S, Tsipras G, Lindblad S, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2014 · Journal Article
James EA, Rieck M, Pieper J, Gebe JA, et al.
Clinical and experimental immunology · 2016 · Journal Article
Sandin C, Eriksson P, Segelmark M, Skogh T, et al.