📇 Rhumatologue ·

M Yves SAMSON

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3 raisons identifiées

Encadrant universitaire
Forme la prochaine génération de rhumatologues (4 thèses dirigées)
Praticien-chercheur
17 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 3 fois dans les médias — pédagogie reconnue

Rhumatologue

RPPS 10000402890

Enseignement

📊 Reconnaissance scientifique : 68/100📝 339 articles publiés🇫🇷 Publications académiques françaises (8)🎓 4 thèses dirigées

✨ Génération du profil synthétique IA en cours…

Direction de thèses

🎓 4 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

The New England journal of medicine · 2020

📚 390 citations🎯 RCR 21.83Top 1% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke

The New England journal of medicine · 2021

📚 344 citations🎯 RCR 26.37Top 0% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Intensive versus subcutaneous insulin in patients with hyperacute stroke: results from the randomized INSULINFARCT trial

Stroke · 2012

📚 94 citations🎯 RCR 2.94Top 17% NIH🩺 Clinique

Lire l'abstract Crossref ↓

Background and Purpose— Intensive insulin therapy (IIT) has not yet proven its efficacy on stroke prognosis or in the reduction of MRI infarct growth. The INSULINFARCT study aims at determining in patients with hyperacute stroke whether IIT, with a better control of poststroke hyperglycemia, would reduce subsequent MRI infarct growth than usual care with subcutaneous insulin. Methods— One hundred eighty patients with MRI-proven ischemic stroke and with National Institutes of Health Stroke Scale from 5 to 25 at admission (<6 hours) were randomized to receive IIT or usual subcutaneous insulin for 24 hours. Admission hyperglycemia was not required for recruitment. Control MRI and 3-month follow-up (with functional outcome and serious adverse events) were planned. The primary objective was to detect a difference in the proportion of patients with mean capillary glucose test <7 mmol/L during 24 hours. The secondary objective was to investigate whether IIT would reduce infarct growth. The analysis was planned in intention-to-treat. Patients with >3 missing capillary glucose test were excluded (n=4). Results— The proportion of patients with mean capillary glucose test <7 mmol/L in the first 24 hours was higher in the IIT group (95.4% [83 of 87] versus 67.4% [60 of 89]; P <0.0001). The infarct growth was lower in the subcutaneous insulin group (median, 10.8 cm 3 ; 95% CI, 6.5–22.4 versus 27.9 cm 3 ; 14.6–40.7; 60% of increase; P =0.04). The 3-month functional outcome (45.6% [41 of 90] versus 45.6% [41 of 90]), death (15.6% [14 of 90] versus 10% [9 of 90]), and serious adverse events (38.9% [35 of 90] versus 35.6% [32 of 90]) were similar in the subcutaneous insulin and IIT group. Conclusion— The IIT regimen improved glucose control in the first 24 hours of stroke but was associated with larger infarct growths. IIT cannot be recommended in hyperacute ischemic stroke. Clinical Trial Registration— URL: http://clinicaltrials.gov . Unique Identifier: NCT00472381.

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M Yves SAMSON

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Direction de thèses

Activité de recherche & publications

Publications académiques en France

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Articles de presse (3)

Top publications · les plus citées

Publications scientifiques (17) — classées par pathologie

Essai clinique5

Transversal5

Case report / série2

Revue / méta-analyse2

Biomarqueurs / Auto-Ac1

IRM ostéo-articulaire1

Pharmacovigilance1

Revue générale1

Vraie vie / RWE1

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