📇 Rhumatologue · PARIS · (75) · Mixte
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4 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Praticien-chercheur
12 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Study of vocal fold vibration using M-mode ultrasound: a proof of concept
2025CongrèsInterspeech 2025
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CABINET DU DR AGNES ROUXEL
14 AVENUE RENE COTY, 75014 PARIS
GHU APHP HU PSSD SITE AVICENNE
125 R DE STALINGRAD, 93009 BOBIGNY CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
European journal of endocrinology · 2013
ObjectiveTo evaluate prospectively the diagnostic accuracy of the thyroid imaging reporting and data system (TI-RADS) and its interobserver agreement and to estimate the reduction of indications of fine-needle aspiration biopsies (FNABs).DesignA prospective comparative study was designed.MethodsIn 2 years, 4550 nodules in 3543 patients were prospectively scored using a flowchart and a six-point scale and then submitted to US-FNAB. Results were read according to the Bethesda system. Histopathological results were available for 263 cases after surgery. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value, and accuracy were calculated for the gray-scale score, elastography, and a combination of both methods. Interobserver agreement was calculated using the kappa statistic. The reduction in the number of FNABs was estimated.ResultsWhen compared with cytopathological results, sensitivity, specificity, NPV, and accuracy were 95.7, 61, 99.7, and 62% for the TI-RADS gray-scale score; 74.2, 91.1, 98, and 90% for elastography; and 98.5, 44.7, 99.8, and 48.3% for a combination of both methods respectively. When compared with histopathological results, the sensitivity of the gray-scale score, elastography, and a combination of both methods were 93.2, 41.9, and 96.7% respectively. Interobserver agreement for the six-point scale and the recommendation for biopsy were substantial (κ value=0.72 and 0.76 respectively). The reduction in the number of FNABs was estimated to be 33.8%.ConclusionThe TI-RADS score has high sensitivity and NPV for the diagnosis of thyroid carcinoma. A hard nodule should always be considered as suspicious for malignancy but elastography cannot be used alone. Combination of elastography with gray-scale can be used to improve sensitivity or specificity. Interobserver agreement and decrease in unnecessary biopsies are significant.
European journal of endocrinology · 2008
ObjectiveThe goal of this study was to determine whether mutations of meiotic genes, such as disrupted meiotic cDNA (DMC1), MutS homolog (MSH4),MSH5, andS. cerevisiaehomolog (SPO11), were associated with premature ovarian failure (POF).DesignCase–control study.MethodsBlood sampling, karyotype, hormonal dosage, ultrasound, and ovarian biopsy were carried out on most patients. However, the main outcome measure was the sequencing of genomic DNA from peripheral blood samples of 41 women with POF and 36 fertile women (controls).ResultsA single heterozygous missense mutation, substitution of a cytosine residue with thymidine in exon 2 ofMSH5, was found in two Caucasian women in whom POF developed at 18 and 36 years of age. This mutation resulted in replacement of a non-polar amino acid (proline) with a polar amino acid (serine) at position 29 (P29S). Neither 36 control women nor 39 other patients with POF possessed this genetic perturbation. Another POF patient of African origin showed a homozygous nucleotide change in the tenth ofDMC1gene that led to an alteration of the amino acid composition of the protein (M200V).ConclusionsThe symptoms of infertility observed in theDMC1homozygote mutation carrier and in both patients with a heterozygous substitution in exon 2 of theMSH5gene provide indirect evidence of the role of genes involved in meiotic recombination in the regulation of ovarian function.MSH5andDMC1mutations may be one explanation for POF, albeit uncommon.
European journal of endocrinology · 2009
ObjectivePremature ovarian failure (POF) encompasses a heterogeneous spectrum of conditions, with phenotypic variability among patients. The etiology of POF remains unknown in most cases. We performed a global phenotyping of POF women with the aim of better orienting attempts at an etiological diagnosis.Design and methodsWe performed a mixed retrospective and prospective study of clinical, biological, histological, morphological, and genetic data relating to 357 consecutive POF patients between 1997 and 2008. The study was conducted at a reproductive endocrinology referral center.ResultsSeventy-six percent of the patients presented with normal puberty and secondary amenorrhea. Family history was present in 14% of the patients, clinical and/or biological autoimmunity in 14.3%. Fifty-six women had a fluctuating form of POF. The presence of follicles was suggested at ultrasonography in 50% of the patients, and observed in 29% at histology; the negative predictive value of the presence of follicles at ultrasonography was 77%. Bone mineral density alterations were found in 58% of the women. Eight patients had X chromosomal abnormalities other than Turner's syndrome, eight other patients evidenced FMR1 pre-mutation. Two other patients had autoimmune polyendocrine syndrome type 2 and 1.ConclusionA genetic cause of POF was identified in 25 patients, i.e. 7% of the whole cohort. POF etiology remains most often undiscovered. Novel strategies of POF phenotyping are in such content mandatory to improve the rate of POF patients for whom etiology is identified.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
European thyroid journal · 2026 · Journal Article
Marchand JG, Bienvenu-Perrard M, Rouxel A, Ghander C, et al.
European thyroid journal · 2026 · Journal Article
Marchand JG, Bienvenu-Perrard M, Rouxel A, Ghander C, et al.
World journal of surgery · 2019 · Evaluation Study
Amadou C, Bera G, Ezziane M, Chami L, et al.
Thyroid : official journal of the American Thyroid Association · 2017 · Evaluation Study
Bardet S, Ciappuccini R, Pellot-Barakat C, Monpeyssen H, et al.
European journal of endocrinology · 2013 · Comparative Study
Russ G, Royer B, Bigorgne C, Rouxel A, et al.
Thyroid : official journal of the American Thyroid Association · 2011 · Clinical Trial
Esnault O, Franc B, Ménégaux F, Rouxel A, et al.
Hormone research · 2008 · Journal Article
Bachelot A, Chakthoura Z, Rouxel A, Dulon J, et al.
Journal of the American College of Surgeons · 2006 · Comparative Study
Gaujoux S, Leenhardt L, Trésallet C, Rouxel A, et al.
The Journal of clinical endocrinology and metabolism · 2004 · Journal Article
Rouxel A, Hejblum G, Bernier MO, Boëlle PY, et al.
European journal of endocrinology · 2009 · Journal Article
Bachelot A, Rouxel A, Massin N, Dulon J, et al.
European journal of endocrinology · 2008 · Journal Article
Mandon-Pépin B, Touraine P, Kuttenn F, Derbois C, et al.
Journal of voice : official journal of the Voice Foundation · 2026 · Journal Article
Massis H, Elmerich A, Frouin F, Trésallet C, et al.
✨ Profil synthétique
IA · 19/05/2026MME AGNES ROUXEL est une rhumatologue exerçant à Paris. Ses publications sur PubMed couvrent des sujets tels que la génétique et les revues générales dans le domaine de la rhumatologie. Elle contribue ainsi à la recherche et à la compréhension des aspects génétiques des maladies rhumatismales.
Expertises présumées
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.