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Auteur de référence en rhumatologie
41 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
119.7 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CDR - ARRONDISSEMENT SUD
44 B R ARCHAMBAUD BP 343, 97410 ST PIERRE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
BMJ (Clinical research ed.) · 2023
Abstract Objective To review the comparative effectiveness of osteoporosis treatments, including the bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in postmenopausal women, and to characterise the effect of antiosteoporosis drug treatments on the risk of fractures according to baseline risk factors. Design Systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials. Data sources Medline, Embase, and Cochrane Library to identify randomised controlled trials published between 1 January 1996 and 24 November 2021 that examined the effect of bisphosphonates, denosumab, selective oestrogen receptor modulators, parathyroid hormone receptor agonists, and romosozumab compared with placebo or active comparator. Eligibility criteria for selecting studies Randomised controlled trials that included non-Asian postmenopausal women with no restriction on age, when interventions looked at bone quality in a broad perspective. The primary outcome was clinical fractures. Secondary outcomes were vertebral, non-vertebral, hip, and major osteoporotic fractures, all cause mortality, adverse events, and serious cardiovascular adverse events. Results The results were based on 69 trials (>80 000 patients). For clinical fractures, synthesis of the results showed a protective effect of bisphosphonates, parathyroid hormone receptor agonists, and romosozumab compared with placebo. Compared with parathyroid hormone receptor agonists, bisphosphonates were less effective in reducing clinical fractures (odds ratio 1.49, 95% confidence interval 1.12 to 2.00). Compared with parathyroid hormone receptor agonists and romosozumab, denosumab was less effective in reducing clinical fractures (odds ratio 1.85, 1.18 to 2.92 for denosumab v parathyroid hormone receptor agonists and 1.56, 1.02 to 2.39 for denosumab v romosozumab). An effect of all treatments on vertebral fractures compared with placebo was found. In the active treatment comparisons, denosumab, parathyroid hormone receptor agonists, and romosozumab were more effective than oral bisphosphonates in preventing vertebral fractures. The effect of all treatments was unaffected by baseline risk indicators, except for antiresorptive treatments that showed a greater reduction of clinical fractures compared with placebo with increasing mean age (number of studies=17; β=0.98, 95% confidence interval 0.96 to 0.99). No harm outcomes were seen. The certainty in the effect estimates was moderate to low for all individual outcomes, mainly because of limitations in reporting, nominally indicating a serious risk of bias and imprecision. Conclusions The evidence indicated a benefit of a range of treatments for osteoporosis in postmenopausal women for clinical and vertebral fractures. Bone anabolic treatments were more effective than bisphosphonates in the prevention of clinical and vertebral fractures, irrespective of baseline risk indicators. Hence this analysis provided no clinical evidence for restricting the use of anabolic treatment to patients with a very high risk of fractures. Systematic review registration PROSPERO CRD42019128391.
The British journal of dermatology · 2024
Abstract Background Interest in the use of omalizumab to treat bullous pemphigoid (BP) in the event of resistance or contraindication to conventional therapies is currently based on limited evidence. Objectives To assess the effectiveness and safety of omalizumab in BP and to identify predictive factors in response to treatment. Methods We conducted a French national multicentre retrospective study including patients with a confirmed diagnosis of BP treated with omalizumab after failure of one or several treatment lines. We excluded patients with clinically atypical BP, as per Vaillant’s criteria. The criteria for clinical response to omalizumab were defined according to the 2012 international consensus conference. Anti-BP180-NC16A IgE enzyme-linked immunosorbent assay was performed on sera collected before initiating omalizumab, when available. Results Between 2014 and 2021, 100 patients treated in 18 expert departments were included. Median age at diagnosis was 77 years (range 20–98). Complete remission (CR) was achieved in 77% of patients, and partial remission in an additional 9%. CR was maintained ‘off therapy’ in 11.7%, ‘on minimal therapy’ in 57.1%, and ‘on non-minimal therapy’ in 31.2%. Median time to CR was 3 months (range 2.2–24.5). Relapse rate was 14%, with a median follow-up time of 12 months (range 6–73). Adverse events occurred in four patients. CR was more frequently observed in patients with an increased serum baseline level of anti-BP180-NC16A IgE (75% vs. 41%; P = 0.011). Conversely, urticarial lesions, blood total IgE concentration or eosinophil count were not predictive of CR. Patients with an omalizumab dosage > 300 mg every 4 weeks showed a similar final outcome to those with a dosage ≤ 300 mg every 4 weeks, but control of disease activity [median 10 days (range 5–30) vs. 15 days (range 10–60); P < 0.001] and CR [median 2.4 months (range 2.2–8.2) vs. 3.9 months (range 2.3–24.5); P < 0.001] were achieved significantly faster. Conclusions We report the largest series to date of BP treated by omalizumab and confirm its effectiveness and safety in this indication. Serum baseline level of anti-BP180-NC16A IgE may predict response to treatment.
Arthritis & rheumatology (Hoboken, N.J.) · 2022
ObjectiveRecent findings have demonstrated that intraarticular (IA) glucocorticoid injections can be deleterious for knees with osteoarthritis (OA). This study was undertaken to assess, in a real‐life setting, the risk of knee OA progression in patients who received IA glucocorticoid injections over a 5‐year follow‐up period.MethodsWe used marginal structural modeling with inverse probability of treatment weighting to determine the causal association between IA glucocorticoid injections and the 5‐year risk of disease progression in patients with symptomatic knee OA from the Knee and Hip Osteoarthritis Long‐term Assessment cohort. OA progression was defined as an incident total knee replacement (TKR) and/or radiographic worsening (Kellgren/Lawrence [K/L] grade or joint space narrowing [JSN]). We also examined these outcomes in knees that received IA hyaluronan (IAHA) injections.ResultsAmong the 564 patients with knee OA included in the study sample, 51 (9.0%) and 99 (17.5%) received IA glucocorticoid or IAHA injections, respectively, and 414 (63.1%) did not receive any injection during follow‐up. Compared to untreated knees, those treated with IA glucocorticoid injections had a similar risk of incident TKR (hazard ratio [HR] 0.92 [95% confidence interval (95% CI) 0.20, 4.14]; P = 0.91) or K/L grade worsening (HR 1.33 [95% CI 0.64, 2.79]; P = 0.44). IAHA injections had no effect on the risk of TKR (HR 0.81 [95% CI 0.14, 4.63]; P = 0.81) or K/L grade worsening (HR 1.36 [95% CI 0.85, 2.17]; P = 0.20). Similar results were obtained for JSN, and when TKR and radiographic outcomes were combined.ConclusionIn this study, IA glucocorticoid injections for symptomatic knee OA did not significantly increase the 5‐year risk of incident TKR or radiographic worsening. These findings should be interpreted cautiously and replicated in other cohorts.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
JBMR plus · 2026 · Journal Article
Herrou J, Beeker N, Cormier Daire V, Cohen Solal M, et al.
Rheumatology advances in practice · 2026 · Journal Article
Genovese J, Matei I, Passeron T, Roux CH
Joint bone spine · 2026 · Editorial
Roux CH, Gonzelez JF, Sedat J, Sidibe M, et al.
Joint bone spine · 2026 · Journal Article
Courties A, Daste C, Homs AF, Kouki I, et al.
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Garnero P, Guillemin F, Ngueyon Sime W, Gineyts E, et al.
Joint bone spine · 2025 · Journal Article
Tilotta F, Gosset M, Herrou J, Briot K, et al.
Joint bone spine · 2024 · Editorial
Roux C
Bone reports · 2024 · Journal Article
Chevalier K, Hamroun S, Bitoun S, Henry J, et al.
Clinical and experimental rheumatology · 2024 · Observational Study
Kumaradev S, Roux C, Sellam J, Perrot S, et al.
The British journal of dermatology · 2024 · Multicenter Study
Chebani R, Lombart F, Chaby G, Dadban A, et al.
RMD open · 2022 · Letter
Bouchut A, Al Tabaa O, Descamps E, Puechal X, et al.
Joint bone spine · 2022 · Letter
Cavagna P, Hubert J, Bottois C, Lopez-Medina C, et al.
Annals of the rheumatic diseases · 2022 · Journal Article
Richebé P, Coiffier G, Guggenbuhl P, Mulleman D, et al.
Joint bone spine · 2022 · Journal Article
Roux C, Cortet B, Chapurlat R, Lévy-Weil FE, et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022 · Journal Article
Beaudart C, Boonen A, Li N, Bours S, et al.
RMD open · 2025 · Journal Article
Triboulet F, Juge PA, Truchetet ME, Pham T, et al.
Joint bone spine · 2023 · Journal Article
Amigues C, Fresse A, Roux CH, Gauthier S, et al.
International journal of molecular sciences · 2023 · Journal Article
The Lancet. Rheumatology · 2026 · Journal Article
Courties A, Tuffet S, Cormier G, Roux CH, et al.
Annals of the rheumatic diseases · 2025 · Journal Article
Ruyssen-Witrand A, Brusq C, Masson M, Bongard V, et al.
BMJ (Clinical research ed.) · 2023 · Systematic Review
Osteoarthritis and cartilage open · 2023 · Journal Article
Ferrero S, Louvois M, Barnetche T, Breuil V, et al.
Expert review of gastroenterology & hepatology · 2023 · Journal Article
Tahrani AA, Panova-Noeva M, Schloot NC, Hennige AM, et al.
BMJ (Clinical research ed.) · 2023 · Systematic Review
Händel MN, Cardoso I, von Bülow C, Rohde JF, et al.
Annals of the rheumatic diseases · 2025 · Journal Article
Ruyssen-Witrand A, Brusq C, Masson M, Bongard V, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2022 · Journal Article
Latourte A, Rat AC, Omorou A, Ngueyon-Sime W, et al.
The Lancet. Rheumatology · 2025 · Journal Article
Morel J, Dernis E, Roux C, Richez C, et al.
Seminars in arthritis and rheumatism · 2024 · Randomized Controlled Trial
Ferrero S, Roux CH
Joint bone spine · 2026 · Letter
Truchetet ME, Prati C, Thevenot P, Bologna C, et al.
The Lancet. Rheumatology · 2025 · Clinical Trial, Phase II
Saraux A, Carvajal Alegria G, Dernis E, Roux C, et al.
Clinical and experimental rheumatology · 2025 · Journal Article
Bottois C, Lopez Medina C, Dumas S, Hubert J, et al.
BMJ (Clinical research ed.) · 2023 · Systematic Review
Händel MN, Cardoso I, von Bülow C, Rohde JF, et al.
Osteoarthritis and cartilage open · 2023 · Journal Article
Ferrero S, Louvois M, Barnetche T, Breuil V, et al.
BMJ (Clinical research ed.) · 2023 · Systematic Review
Händel MN, Cardoso I, von Bülow C, Rohde JF, et al.
Journal of clinical medicine · 2026 · Journal Article
Barbaro LE, Bustamente L, Evenor L, Villain A, et al.
Journal of vascular and interventional radiology : JVIR · 2023 · Journal Article
Chau Y, Roux C, Gonzalez JF, Breuil V, et al.
Therapeutic advances in musculoskeletal disease · 2022 · Journal Article
Trojani MC, Chorin F, Gerus P, Breuil V, et al.
Rheumatology (Oxford, England) · 2024 · Journal Article
Assaraf M, Chevet B, Wendling D, Philippe P, et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022 · Journal Article
Thomas T, Tubach F, Bizouard G, Crochard A, et al.
BMC pediatrics · 2026 · Journal Article
Truter C, Hamilton MS, Le Roux C, Berndorfler B, et al.
Nursing outlook · 2025 · Journal Article
Toniolo J, Iroukora E, Colven Y, Dessi FA, et al.
Diabetes, obesity & metabolism · 2026 · Journal Article
Giblin K, Kaplan LM, Somers VK, Le Roux CW, et al.
Rheumatology (Oxford, England) · 2025 · Journal Article
Bletry D, Meyblum L, Desseaux K, Vautier M, et al.
Roux CH, Rousseau AS, Iannelli A, Gautier N, et al.
Journal of the South African Veterinary Association · 2022 · Journal Article
Hollenbach E, Robert MP, le Roux C, Smit Y
Joint bone spine · 2022 · Journal Article
Molto A, Pinson P, Beeker N, Roux C
Händel MN, Cardoso I, von Bülow C, Rohde JF, et al.
The Journal of rheumatology · 2022 · Randomized Controlled Trial
Labat G, Hayotte M, Bailly L, Fabre R, et al.
Therapeutic advances in musculoskeletal disease · 2022 · Journal Article
Trojani MC, Chorin F, Gerus P, Breuil V, et al.