📇 Rhumatologue · Salarié
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3 raisons identifiées
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue
Expérience confirmée
36 ans d'exercice en rhumatologie — recul clinique solide
Disponibilité géographique
3 lieux d'exercice — choisissez celui qui vous arrange
36ans d'exercice (thèse 1990)
✨ Génération du profil synthétique IA en cours…
Source : catalogue national des thèses (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
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📰 Le Quotidien du Médecin · 17/07/2019
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📰 RTN.ch · 28/09/2020
<a href="https://news.google.com/rss/articles/CBMirgFBVV95cUxNYTB6bkVtUkhTTmNfa1RvakU2a2tTWGl6YW1rR1pPU2FaYjRiMXNkaFZwMkNkTnFIZjRzZGF6dk42QmhVcExnbGw0STRRVk9RYnpackVKQm5qeWNxQTR0Q2V3OHp5ZzJheUc5c2wtWEFubm5VbUFxNGlOM1BOTVZTRmlaTjBRdW5takowOTRBZmM4aVdHWC1YUS1MLXg4S1B6YkZCbXdBeTdZMUV0V3c?oc=5" target="
Heart (British Cardiac Society) · 2006
Objective: To compare compliance with and effectiveness of adaptive servoventilation (ASV) versus continuous positive airway pressure (CPAP) in patients with the central sleep apnoea syndrome (CSA) with Cheyne-Stokes respiration (CSR) and with congestive heart failure in terms of the apnoea–hypopnoea index (AHI), quality of life, and left ventricular ejection fraction (LVEF) over six months. Methods: 25 patients (age 28–80 years, New York Heart Association (NYHA) class II–IV) with stable congestive heart failure and CSA-CSR were randomly assigned to either CPAP or ASV. At inclusion, both groups were comparable for NYHA class, LVEF, medical treatment, body mass index, and CSA-CSR. Results: Both ASV and CPAP decreased the AHI but, noticeably, only ASV completely corrected CSA-CSR, with AHI below 10/h. At three months, compliance was comparable between ASV and CPAP; however, at six months compliance with CPAP was significantly less than with ASV. At six months, the improvement in quality of life was higher with ASV and only ASV induced a significant increase in LVEF. Conclusion: These results suggest that patients with CSA-CSR may receive greater benefit from treatment with ASV than with CPAP.
The British journal of nutrition · 2007
In addition to their use in cheese technology, dairy propionibacteria have been identified as potential probiotics. However, to have a probiotic effect, propionibacteria have to survive and to remain metabolically active in the digestive tract. The aim of the present study was to investigate the survival and metabolic activity ofPropionibacterium freudenreichiiwithin the gastrointestinal tract of human microbiota-associated rats, and its influence on intestinal microbiota composition and metabolism. Twenty-five dairyPropionibacteriumstrains were screened for their tolerance towards digestive stresses and their ability to produce propionate in a medium mimicking the content of the human colon. Three strains were selected and a daily dose of 2 × 1010colony-forming units was fed to groups of human microbiota-associated rats for 20 d before microbiological, biochemical and molecular investigations being carried out. These strains all reached 8-log values per g faeces, showing their ability to survive in the gastrointestinal tract. Transcriptional activity within the intestine was demonstrated by the presence ofP. freudenreichii-specific transcarboxylase mRNA. The probiotic efficacy of propionibacteria was yet species- and strain-dependent. Indeed, two of the strains, namely TL133 and TL1348, altered the faecal microbiota composition, TL133 also increasing the caecal concentration of acetate, propionate and butyrate, while the third strain, TL3, did not have similar effects. Such alterations may have an impact on gut health and will thus be taken into consideration for furtherin vivoinvestigations on probiotic potentialities ofP. freudenreichii.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The British journal of nutrition · 2007 · Journal Article
Lan A, Bruneau A, Philippe C, Rochet V, et al.
Heart (British Cardiac Society) · 2006 · Comparative Study
Philippe C, Stoïca-Herman M, Drouot X, Raffestin B, et al.