📇 Rhumatologue · PARIS 15 · (75) · Salarié
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
3 raisons identifiées
Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
COMMISSARIAT A L' ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
BAT LE PONANT D 25 RUE LEBLANC, 75015 PARIS 15
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Psychiatry research · 2006
Neurology · 2012
EJNMMI research · 2013
Abstract Background Statistical parametric mapping (SPM) procedure is an objective tool to analyze 18F-fluoro-2-deoxy-d-glucose-positron-emission tomography (FDG-PET) images and a useful complement to visual analysis. However, SPM requires a comparison to control data set that cannot be obtained in healthy children for ethical reasons. Using adults as controls showed some limitations. The purpose of the present study was to generate and validate a group of pseudo-normal children as a control group for FDG-PET studies in pediatrics. Methods FDG-PET images of 47 children (mean ± SD age 10.2 ± 3.1 years) with refractory symptomatic (MRI-positive, n = 20) and cryptogenic (MRI-negative, n = 27) focal epilepsy planned for surgery were analyzed using visual and SPM analysis. Performances of SPM analysis were compared using two different control groups: (1) an adult control group consisting of healthy young adults (n = 25, 30.5 ± 5.8 years, adult PET template) and (2) a pediatric pseudo-control group consisting of patients (n = 24, 10.6 ± 3.1 years, children PET template) with refractory focal epilepsy but with negative MRI and with PET considered normal not only on visual analysis but also on SPM. Results Among the 47 children, visual analysis succeeded detecting at least one hypometabolic area in 87% of the cases (interobserver kappa = 0.81). Regarding SPM analysis, the best compromise between sensitivity and specificity was obtained with a threshold of p less than 0.001 as an extent of more than 40 voxels. There was a significant concordance to detect hypometabolic areas between both SPM analyses [kappa (K) = 0.59; p < 0.005] and between both SPM and visual analyses (K = 0.45; p < 0.005), in symptomatic (K = 0.74; p < 0.005) as in cryptogenic patients (K = 0.26; p < 0.01). The pediatric pseudo-control group dramatically improved specificity (97% vs. 89%; p < 0.0001) by increasing the positive predictive value (86% vs. 65%). Sensitivity remained acceptable although it was not better (79% vs. 87%, p = 0.039). The main impact was to reduce by 41% the number of hypometabolic cortical artifacts detected by SPM, especially in the younger epileptic patients, which is a key point in clinical practice. Conclusions This age-matched pseudo-control group is a way to optimize SPM analysis of FDG-PET in children with epilepsy. It might also be considered for other brain pathologies in pediatrics in the future.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
European journal of nuclear medicine and molecular imaging · 2025 · Journal Article
Breuil L, Arino I, El Biali M, Rodrigo S, et al.
Neurology · 2023 · Journal Article
Cheval M, Rodrigo S, Taussig D, Caillé F, et al.
Alzheimer's research & therapy · 2023 · Journal Article
Lagarde J, Olivieri P, Tonietto M, Rodrigo S, et al.
Acta neurologica Belgica · 2023 · Journal Article
Cheval M, Rodrigo S, Petrescu AM, Leroy C, et al.
Neurology · 2012 · Journal Article
Chassoux F, Rodrigo S, Mellerio C, Landré E, et al.
AJR. American journal of roentgenology · 2011 · Journal Article
Rios AM, Rosenberg ZS, Bencardino JT, Rodrigo SP, et al.
Surgical and radiologic anatomy : SRA · 2011 · Comparative Study
Holl N, Noblet V, Rodrigo S, Dietemann JL, et al.
Epilepsia · 2008 · Journal Article
Rodrigo S, Oppenheim C, Chassoux F, Hodel J, et al.
Psychiatry research · 2006 · Journal Article
Naggara O, Oppenheim C, Rieu D, Raoux N, et al.
EJNMMI research · 2013 · Journal Article
Archambaud F, Bouilleret V, Hertz-Pannier L, Chaumet-Riffaud P, et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2011 · Journal Article
Mazzuca M, Jambaque I, Hertz-Pannier L, Bouilleret V, et al.
Neuroimaging clinics of North America · 2014 · Journal Article
Hertz-Pannier L, Noulhiane M, Rodrigo S, Chiron C
EJNMMI research · 2024 · Journal Article
Rodrigo S, Costi S, Ellul P, Aubart M, et al.