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3 raisons identifiées
Auteur de référence en rhumatologie
28 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 4 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
184.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR IVAN PROTHOY
POLYCLINIQUE ALPES DU SUD 3 RUE ANTONIN CORONAT, 05000 GAP
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Le Dauphiné Libéré · 27/11/2022
<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxQZEZxQllaelF6eVFlbFBaYUQ1M2ZreXJxZU01STgxY2p4enJMVXZ4TXY3QncyYjRfaDNoTDhiY0FDUUxHWXNZV1VHRWVqa1Jzdkd5R2I4NjhBUzZHbWpMYzR5eFBudERMSlY4bm0tT0pKb1IxakxVSTFQRzRxcExRNXlYaFFwcmVvZk5tdmxTU3F5Ukx3VnFteTVqdHlCUQ?oc=5" target="_blank">Hautes-Alpes.
📰 La Provence · 24/11/2019
<a href="https://news.google.com/rss/articles/CBMiqwFBVV95cUxNYlFtbHVYTWtNaGp5Z2t4MzZ6SEd1MkpXRFYzRFZ3c3VyMGZsUjFqYUFpZ0lIZUdocWgtcVZKTnVrSXJOWkpkdktiQWhhQ3BleHA2UXJpUFEtTEV2RFFTVHNkQ2dRcjRHcGloWTNkSmw5N0hocndINGZtR193dnpjal8zSV9vdXVfMHN1NVNxdVJncmxWTXU4Y3BwaWhIdGJ1UTJQb3NvMDFfcEE?oc=5" target="_bla
📰 Le Dauphiné Libéré · 17/09/2019
<a href="https://news.google.com/rss/articles/CBMijwFBVV95cUxOYlp3c3paUHRkUHB3eGc2aVpEQmg0NC01Z2U2NnhhUkUzX3F6Y1FRVlF1NHZCMF92QTZLaUJabmxhd2NwVUVUdzEySjhyWkZDTUtILTFXSDN6cjd2dmdHRHJlcWJiZ055aVNEMkNXa01ndmRMWkItS1BUSEtaM0p1Q21kNEJjWGZyc0diaGRzbw?oc=5" target="_blank">« D’un coup, je m’arrête. Je pars
📰 Le Dauphiné Libéré · 27/07/2014
<a href="https://news.google.com/rss/articles/CBMimwFBVV95cUxNRFFNa01xU0lidXUyVExlc2JHMjk5bDY4cmFwYXExWlFoV2NDRUZYbzJURTUyMFJzamJ5WURWZ0ZWdUVxMkJpVjgzTmRWWDRkb3VhNmtncU5HMDFvY0VZaDluVlo1akhPazZZYi1ETkpzaTEyVFJVeE9QcEpfa3dZMnU2V2luWFZoR3BwOHY2VzFzMTBGVHB3REZLUQ?oc=5" target="_blank">« Privilégier le
American journal of obstetrics and gynecology · 2026
Operative neurosurgery (Hagerstown, Md.) · 2026
BACKGROUND AND OBJECTIVES: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults with a median overall survival of 15.6 months. Despite advancements, 5-year survival rates have not significantly improved. Laser interstitial thermal therapy (LITT) has been used to treat both newly diagnosed (nGBM) and recurrent GBM (rGBM) with demonstrable safety and efficacy. Traditionally, LITT has been limited to smaller lesions given physical and thermal constraints. We present 2 case examples of a novel, hybrid treatment approach to GBM, using both surgery and laser ablation as part of a staged procedure. METHODS: Two geriatric (older than 65 years) patients with nGBM or rGBM were treated with surgical resection followed by LITT the subsequent day. Both patients underwent preoperative MRI showing multifocal disease with a dominant component, causing mass effect in the second case, and an unresectable component. RESULTS: The first case underwent surgical resection of a large, multicentric rGBM in the parieto-occipital region, followed by LITT of an unresectable lesion in the inferior temporal gyrus. The second patient underwent surgical resection of the dominant temporal lobe component and LITT of the insular component. Neither patient had intraoperative or ablation complications. Both patients had stable postoperative neurological examinations and were discharged on the day after ablation, with no new deficits at follow-up. CONCLUSION: The prognosis for GBM remains dismal despite attempts at advancements in patient management. Surgical resection is a critical component of the GBM treatment paradigm, although, alone, is not sufficient for maximal therapeutics in many patients. LITT is a minimally invasive means of cytoreduction that has shown promise for improving GBM outcomes. We demonstrate a novel, hybrid approach to GBM using hybrid surgical resection and LITT in a staged procedure to overcome traditional constraints of both open resection or LITT alone.
Molecular cancer therapeutics · 2025
Abstract Glioblastoma, the most aggressive primary brain tumor, carries a dismal prognosis, with median survival remaining under 15 months despite standard therapies. This is largely because of the tumor’s infiltrative nature, the restrictive blood–brain barrier, and intratumoral heterogeneity. Chlorotoxin (CTX), a 36-amino acid peptide derived from scorpion venom, has emerged as a promising multifunctional agent with high specificity for neuroectodermal tumors. In this comprehensive review, we highlight CTX’s potential to address critical limitations of current glioma treatments by bridging diagnostic and therapeutic modalities. Diagnostic advancements include CTX-conjugated near-IF fluorophores and nanoparticles for fluorescence-guided surgery and multimodal imaging to enhance intraoperative accuracy. On the therapeutic front, CTX enables targeted delivery of siRNA, radioisotopes, and novel immunotherapies such as CTX-directed chimeric antigen receptor T cells. We also examine emerging clinical data supporting the safety and preliminary efficacy of CTX-based interventions. Collectively, CTX represents a paradigm shift in neuro-oncology, offering a single molecule with both diagnostic and therapeutic capabilities. Its utility may also extend beyond gliomas to metastases and other malignancies within and beyond the central nervous system.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Healthcare (Basel, Switzerland) · 2026 · Journal Article
Ardelean MV, Buzas DR, Istodor AV, Ciubotaru P, et al.
Physics in medicine and biology · 2026 · Journal Article
Alice B, Massera RT, Ivan V, Cristina L, et al.
Operative neurosurgery (Hagerstown, Md.) · 2026 · Journal Article
Berke CN, Khalafallah AM, Gurses ME, Lu VM, et al.
Medicina (Kaunas, Lithuania) · 2026 · Journal Article
Ardelean MV, Ardelean OF, Buzas DR, Ciubotaru P, et al.
The journal of sexual medicine · 2026 · Journal Article
Ivan SJ, Abou Chawareb E, Hammad M, Lesgart M, et al.
Inquiry : a journal of medical care organization, provision and financing · 2026 · Journal Article
van der Wal H, Sedivcova V, Maas F, Nishikawa B, et al.
American journal of obstetrics and gynecology · 2026 · Journal Article
Ivan M, Banerjee A, Colley C, Tetteh A, et al.
Biology · 2026 · Journal Article
Dragomir AF, Zugravu A, Stoleru S, Poenaru E, et al.
Neuro-oncology advances · 2026 · Journal Article
Regalia C, Young T, Asfaw ZK, Carrasquilla A, et al.
Neurosurgical review · 2026 · Journal Article
Ramsoomair CK, Daftari M, Desai A, Alvarez V, et al.
Children (Basel, Switzerland) · 2026 · Journal Article
Borca CI, Ivan CS, Fira-Mladinescu C, Margan R, et al.
Acta neurochirurgica · 2026 · Journal Article
Mirian C, Jensen LR, Juratli TA, Maier AD, et al.
The Journal of urology · 2026 · Journal Article
Ivan SJ, Chawareb EA, Hammad M, Lesgart M, et al.
Antibiotics (Basel, Switzerland) · 2026 · Journal Article
Popa I, Iancu I, Gligor A, Imre K, et al.
Children (Basel, Switzerland) · 2026 · Journal Article
Borca CI, Alexandru A, Margan MM, Ivan CS, et al.
Clinical neurology and neurosurgery · 2026 · Journal Article
Knott MV, Himic V, Khalafallah AM, Lu VM, et al.
Clinical neurology and neurosurgery · 2026 · Journal Article
Himic V, Mayrand RC, Gersey ZC, Khalafallah AM, et al.
Journal of surgical case reports · 2025 · Case Reports
Alexey S, Ivan I, Tatyana P, Lei X, et al.
Children (Basel, Switzerland) · 2026 · Journal Article
Borca CI, Alexandru A, Margan MM, Ivan CS, et al.
Journal of medicine and life · 2026 · Journal Article
Borca CI, Margan MM, Fira-Mladinescu C, Cindrea AC, et al.
Children (Basel, Switzerland) · 2026 · Journal Article
Borca CI, Ivan CS, Fira-Mladinescu C, Margan R, et al.
Journal of neuro-oncology · 2026 · Journal Article
Otaner F, Himic V, Vargas LO, Abikenari M, et al.
Microbiology spectrum · 2026 · Journal Article
Winterflood DM, Seguí-Crespi G, Peeters C, Lang C, et al.
Journal for immunotherapy of cancer · 2026 · Journal Article
Ramsoomair CK, Daftari M, Benchouia R, Estevez-Ordonez D, et al.
Neurosurgery · 2026 · Journal Article
Shah KH, Khalafallah AM, Knott MV, Himic V, et al.
Children (Basel, Switzerland) · 2026 · Journal Article
Borca CI, Ivan CS, Fira-Mladinescu C, Margan R, et al.
World neurosurgery · 2026 · Journal Article
Kamil R, Dakhel S, Lacuarta K, AbdelAlim YA, et al.
Journal of neuro-oncology · 2026 · Journal Article
Himic V, Lu VM, Mayrand RC, Sass ER, et al.
Operative neurosurgery (Hagerstown, Md.) · 2026 · Journal Article
Babel S, Himic V, Aaronson DM, Gersey ZC, et al.
Clinical neurology and neurosurgery · 2026 · Journal Article
Rivera CA, Ho A, Uppalapati V, Himic V, et al.
World neurosurgery · 2026 · Journal Article
Kamil R, Dakhel S, Lacuarta K, AbdelAlim YA, et al.
Molecular cancer therapeutics · 2025 · Journal Article
Ramsoomair D, Ramsoomair CK, Daftari M, Himic V, et al.