📇 Rhumatologue · DREUX CEDEX · (28) · Salarié
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3 raisons identifiées
Praticien-chercheur
10 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
75.8 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
13
13 articles ont été cités au moins 13fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
787
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
125
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
18
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Les Hôpitaux de Chartres
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CH DREUX
44 AV PRESIDENT JOHN-FIT- KENNEDY BP 69, 28102 DREUX CEDEX
CH CHARTRES LOUIS PASTEUR-LE COUDRAY
8 R CLAUDE BERNARD, 28630 LE COUDRAY
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Pharmaceutics · 2024
Introduction: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by significant autoantibodies, particularly targeting nuclear antigens. SLE pathogenesis involves genetic, environmental, and hormonal factors. The disease course includes flares and remission and involves various organs. Recent therapeutic progresses, including biologics, have improved management and prognosis, though the long-term impact of novel therapies remains to be determined. Biologics in SLE: Rituximab, the earliest B-cell-oriented biologic, binds CD20 and depletes CD20+ B cells, leading to remission in some SLE patients. Belimumab is a B-cell-activating factor (BAFF) inhibitor with a recent additional indication for lupus nephritis. The CALIBRATE and BLISS-BELIEVE studies investigated combinations of these drugs with conventional therapies, showing varied efficacy. Ocrelizumab and obinutuzumab, newer CD20-oriented SLE therapies, together with ofatumumab and veltuzumab, are also promising. The latest trials highlight their efficacy and safety. Anifrolumab, targeting type-I interferon receptors, was evaluated in the TULIP 1/2 trials. The ongoing TULIP LTE trial supports the long-term safety and efficacy of anifrolumab. Additionally, the IRIS Phase III trial is exploring anifrolumab for lupus nephritis, showing favorable renal responses. Tocilizumab and secukinumab are being assessed for SLE, with mixed outcomes. Several biologics targeting the C5 complement protein, together with immunomodulators and immunotherapeutics, are also under investigation for potential benefits in SLE. Discussion: Biologics in SLE target specific immune components, aiming to improve disease control and reduce the side effects of conventional therapy. However, trial outcomes vary due to factors like inclusion criteria and trial design. Conclusions: Biotechnology progress enables targeted biologic therapies for SLE, reducing disease activity and improving patients’ quality of life.
Frontiers in medicine · 2022
It has been proven that vitamins play an essential role in preventing certain diseases since ancient times. It is thus fruitless to approach the roles of vitamins without making reference to the techniques used in evaluating the effects of these micronutrients. Therefore, the aim of this paper was to summarize the immunological effects of E, K, B5, B6, and B9 vitamins evaluated by flow cytometry. Some of these significant effects were presented and discussed: (a) The role of vitamins E in the prevention and treatment of different types of cancer. (b) The properties of K vitamins in the development and maintenance of pheochromocytoma Cell Line 12 (PC12) cells in Parkinson’s disease; (c) The improvement effect of vitamin B5 on the loss of bone mass in low estrogen conditions; (d) The anticancer role of vitamins B6. (e) The role of Vitamin B9 in the regulation of Treg cells. As such, the flow cytometry technique used to assess these properties is essential to evaluate the immunomodulatory effects of certain vitamins. The technique undergoes constant improvement which makes it possible to determine several parameters with a role in the modulation of the immune function and at the same time increase the accuracy of the methods that highlight them.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Cureus · 2024 · Case Reports
Spiridonica R, Popa M, Cursaru A, Iacobescu GL, et al.
Cureus · 2024 · Journal Article
Popa M, Cursaru A, Cretu B, Iordache S, et al.
Cureus · 2024 · Journal Article
Iacobescu GL, Corlatescu AD, Popa M, Iacobescu L, et al.
Frontiers in medicine · 2022 · Journal Article
Munteanu C, Berindean I, Mihai M, Pop B, et al.
Experimental and therapeutic medicine · 2019 · Journal Article
Cristea D, Trandafir M, Bojinca VC, Ciontea AS, et al.
Current issues in molecular biology · 2024 · Journal Article
Iacobescu GL, Iacobescu L, Popa MIG, Covache-Busuioc RA, et al.
European review for medical and pharmacological sciences · 2022 · Journal Article
Babalic FCA, Borza C, Ilie Rosca C, Gurban CV, et al.
BMC ophthalmology · 2026 · Journal Article
Simaku E, Eddien AN, Popa M, Shafei AE
Cureus · 2024 · Journal Article
Iordache S, Cursaru A, Marinescu A, Cretu B, et al.
Pharmaceutics · 2024 · Journal Article
Kundnani NR, Levai MC, Popa MD, Borza C, et al.
Studii de istorie a filosofiei românești, XVI: Relația minte-corp
"Studii de istorie a filosofiei româneşti" [Studies on the History of Romanian Philosophy] is an academic peer-reviewed annual publication which was founded in 2006 with the aim of promoting new researches on the concept
Asymptotic free independence and entry permutations for Gaussian random matrices
The paper presents conditions on entry permutations that induce asymptotic freeness when acting on Gaussian random matrices. The class of permutations described includes the matrix transpose, as well as entry permutation
Realization of conditionally monotone independence and monotone products of completely positive maps
The paper gives an operator algebras model for the conditional monotone independence, introduced by T. Hasebe. The construction is used to prove an embedding result for the N. Muraki's monotone product of C*-algebras. Al
On multiplicative conditionally free convolution
Using the combinatorics of non-crossing partitions, we construct a conditionally free analogue of the Voiculescu's S-transform. The result is applied to analytical description of conditionally free multiplicative convolu
Non-Commutative Functions and Non-Commutative Free Levy-Hincin Formula
The paper is discussing infinite divisibility in the setting of operator-valued boolean, free and, more general, c-free independences. Particularly, using Hilbert bimodules and non-commutative functions techniques, we ob
A Non-commutative analogue of Gaussian Hilbert Spaces
The paper gives analogues of some starting results in the theory of Gaussian Hilbert Spaces for semicircular distributed random variables. The transition from the commutative to the free frame is done considering matrice
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).