📇 Rhumatologue · CLICHY CEDEX · (92) · Hospitalier
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2 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Délais de RDV courts dans la région
136 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
GHU APHP NUP SITE BEAUJON
100 BD DU GENERAL LECLERC, 92118 CLICHY CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
United European gastroenterology journal · 2024
Abstract Background Hepaticogastrostomy drainage through endoscopic ultrasound (EUS‐HGS) has emerged in the 2010s as a new technique for biliary decompression in cases of endoscopic retrograde cholangiopancreatography (ERCP) failure for malignant biliary obstruction (MBO). Substantial technical and procedural progress in performing EUS‐HGS has been achieved, allowing high technical and clinical success and an acceptable risk of adverse events in studies mainly focusing on short‐term outcomes. However, the long‐term effects of EUS‐HGS and the risk of recurrent biliary obstruction (RBO) have not been fully evaluated. Objectives To evaluate the long‐term effects of EUS‐HGS and the risk of RBO. Methods Data from 211 patients undergoing technically successful EUS‐HGS in three academic centers were retrospectively collected. Clinical success, adverse events, RBO, and reinterventions were evaluated. Results In total, 198 patients underwent technically successful EUS‐HGS for MBO. The median overall survival was 144 days [108, 2011] after the procedure. Mean patient age was 69.39 (12.91) years. The cause of MBO was pancreatic cancer ( n = 98, 49.5%) followed by cholangiocarcinoma ( n = 29, 14.6%). The location of MBO was distal in 27.6% of cases and proximal in 68.4%. Adverse events were observed during the follow‐up in 65 patients (33%). On multivariate analysis, the use of partially covered self‐expandable metal stents (PCSEMS) was associated with a lower risk of RBO (HR = 0.47 [0.24–0.95], p = 0.034). Additionally, patients with distal stenoses had a trend toward better stent patency (HR = 0.06[0—0.77], p = 0.031). RBO developed in 38 cases (19.1%) mainly due tumor ingrowth (36.8%) with a high success rate of endoscopic management. Conclusions While RBO occurred in a notable proportion of patients, the primary cause of mortality was progression of the underlying malignancy rather than stent dysfunction. The efficiency of stents, particularly PCSEMS, and the high success rate of endoscopic management for RBO underscore the effectiveness and reliability of these treatments in managing biliary complications.
Case reports in oncology · 2016
<b><i>Introduction:</i></b> At the onset of the 20th century, ancient clinical observations of cancer epidemics in Bantu populations of Sub-Saharan Africa were discovered. They were reported from 1914 to 1960, but remained unexplained. In 1983, in San Francisco, Calif., USA, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (HIV-1) known as AIDS disease. Yet since 1996, it is known that HIV-1 strains are not the only ones involved. In Sub-Saharan Africa, recurrent orobuccal herpes simplex virus type 1 (HSV-1) and genital recurrent herpes simplex virus type 2 (HSV-2) appeared many times prior to infection by HIV-1. <b><i>Case Reports:</i></b> Data on these ancient medical observations regarding African cancer epidemics can today be referred to as the relationship between the unfortunate immune deficiency of herpes in Bantu populations and HIV-1 viral strains. For centuries, the Bantu populations dispersed in forests were living in close proximity to chimpanzees infected by simian immunodeficiency virus (SIV) and were exposed to SIV contamination which became HIV-1 in human beings. Presently, these unexplained Bantu cancer epidemics can be linked to the viral partnership of HSV-1/HSV-2 to HIV-1 strains. <b><i>Conclusion:</i></b> The key issue is now to prevent HSV-1/HSV-2 diseases related to HIV-1. An anti-herpes treatment administered early during childhood to Bantu populations will offer a mean of preventing herpes diseases related to HIV-1 infection and hence avoid cancer epidemics.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Case reports in oncology · 2016 · Case Reports
Le Goaster J, Bouree P, El Sissy FN, Phuong Bui F, et al.
United European gastroenterology journal · 2024 · Journal Article
Hedjoudje A, Pokossy Epée J, Perez-Cuadrado-Robles E, Alric H, et al.