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Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
119.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
HOPITAL CHARLES NICOLLE CHU ROUEN
1 R DE GERMONT, 76000 ROUEN
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Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Actu.fr · 01/03/2020
<a href="https://news.google.com/rss/articles/CBMi0wFBVV95cUxQMzJYVnBtZHVscFdKWWh0b0tKQkxUWVJOcGw1eFZPUmlDYk5yVE93eERCUE5LanEyczh5V1hjeVRPUnhMdGI0YWVxUkJ3MkwwZWJQMElJYnM4WDlpY1YweVV6azI0ZVZsemNKcWRqeFR5ci1Ubm1FX1N1SlcyRmc0eHJFMWdDb1JrXzFWdFMzQk5mTTJsUGdTOGY3aUhvbjVvSnJBQkN0Y3FHYUpDanRNVndwWkhWc1RjbF
Rhinology · 2020
Circulation · 1995
Background Experimental evidence suggests that flow-dependent dilatation of conduit arteries is mediated by nitric oxide (NO) and/or prostacyclin. The present study was designed to assess whether NO or prostacyclin also contributes to flow-dependent dilatation of conduit arteries in humans. Methods and Results Radial artery internal diameter (ID) was measured continuously in 16 healthy volunteers (age, 24±1 years) with a transcutaneous A-mode echo-tracking system coupled to a Doppler device for the measurement of radial blood flow. In 8 subjects, a catheter was inserted into the brachial artery for measurement of arterial pressure and infusion of the NO synthase inhibitor N G -monomethyl- l -arginine (L-NMMA; 8 μmol/min for 7 minutes; infusion rate, 0.8 mL/min). Flow-dependent dilatation was evaluated before and after L-NMMA or aspirin as the response of the radial artery to an acute increase in flow (reactive hyperemia after a 3-minute cuff wrist occlusion). Under control conditions, release of the occlusion induced a marked increase in radial blood flow (from 24±3 to 73±11 mL/min; P <.01) followed by a delayed increase in radial diameter (flow-mediated dilatation; from 2.67±0.10 to 2.77±0.12 mm; P <.01) without any change in heart rate or arterial pressure. L-NMMA decreased basal forearm blood flow (from 24±3 to 13±3 mL/min; P <.05) without affecting basal radial artery diameter, heart rate, or arterial pressure, whereas aspirin (1 g PO) was without any hemodynamic effect. In the presence of L-NMMA, the peak flow response during hyperemia was not affected (76±12 mL/min), but the duration of the hyperemic response was markedly reduced, and the flow-dependent dilatation of the radial artery was abolished and converted to a vasoconstriction (from 2.62±0.11 to 2.55±0.11 mm; P <.01). In contrast, aspirin did not affect the hyperemic response nor the flow-dependent dilatation of the radial artery. Conclusions The present investigation demonstrates that NO, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries. Hence, this response can be used as a test for the l -arginine/NO pathway in clinical studies.
Circulation · 2009
Background— Antiplatelet therapy is often discontinued in patients with drug-eluting stents who are undergoing surgical procedures. However, discontinuation of antiplatelet therapy is an important risk factor for late stent thrombosis. Our objective was to examine the safety of short-term discontinuation of antiplatelet therapy. Methods and Results— We systematically searched Medline for reported cases of late stent thrombosis and very late stent thrombosis published between January 2001 and July 2008. We restricted our search to Academic Research Consortium–defined definite cases. We identified 161 cases of late stent thrombosis or very late stent thrombosis from 84 articles (79 from case reports, 61 from registries, and 21 from randomized clinical trials). Patients had a mean age of 58.4±13.4 years, and 88% were male. A total of 19 cases occurred in patients who were receiving dual antiplatelet therapy at the time of the event. If patients stopped both antiplatelet agents simultaneously, the median time to event was 7 days. If patients had previously stopped a thienopyridine with no ill effect and subsequently stopped acetylsalicylic acid, the median time to event was also 7 days from the time of acetylsalicylic acid cessation. If the thienopyridine was stopped but acetylsalicylic acid was maintained, the median time to event was 122 days. Among the 48 patients who stopped both agents, 36 cases (75%) occurred within 10 days. Among the 94 patients who discontinued a thienopyridine but continued acetylsalicylic acid, only 6 cases (6%) occurred within 10 days. Conclusion— If acetylsalicylic acid therapy is maintained, short-term discontinuation of a thienopyridine may be relatively safe in patients with drug-eluting stents.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Plant disease · 2026 · Journal Article
Belair M, Picot A, Masson C, Hébrard MN, et al.
iScience · 2026 · Journal Article
Richard M, Singh KD, Sezer D, Buergler S, et al.
Blood purification · 2025 · Journal Article
Chivot M, Bellomo R, Deniel G, Richard JC, et al.
Critical care (London, England) · 2025 · Journal Article
Bidar F, Chardon N, Darnajoux Q, Petit M, et al.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025 · Journal Article
Yahia MI, Marnat G, Finitsis S, Sibon I, et al.
The Journal of clinical investigation · 2024 · Journal Article
Choi YJ, Richard G, Zhang G, Hodgin JB, et al.
Blood purification · 2024 · Journal Article
Chivot M, Baldwin I, Deniel G, David G, et al.
Diabetes, obesity & metabolism · 2024 · Journal Article
Khiar H, Lévêque E, Lopez AG, Moreau-Grangé L, et al.
Scientific reports · 2024 · Journal Article
Aniort J, Richard F, Thouy F, Le Guen L, et al.
Journal of neurointerventional surgery · 2023 · Multicenter Study
Pop R, Burel J, Finitsis SN, Papagiannaki C, et al.
Open heart · 2022 · Clinical Trial
Seecheran NA, Sukha D, Grimaldos K, Grimaldos G, et al.
Fundamental & clinical pharmacology · 2021 · Journal Article
Eiden C, Vincent M, Serrand C, Serre A, et al.
Cardiology and therapy · 2021 · Journal Article
Seecheran N, Grimaldos K, Ali K, Grimaldos G, et al.
Rhinology · 2020 · Journal Article
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, et al.
Journal of aging research · 2020 · Journal Article
Franey EG, Kritz-Silverstein D, Richard EL, Alcaraz JE, et al.
The Journal of frailty & aging · 2016 · Journal Article
Bousquet J, Bourret R, Camuzat T, Augé P, et al.
Clinical toxicology (Philadelphia, Pa.) · 2015 · Journal Article
Torrents R, Picot C, Glaizal M, Courne MA, et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2013 · Case Reports
Monet C, Richard E, Missonnier S, Rebouissoux L, et al.
Cerebrovascular diseases (Basel, Switzerland) · 2012 · Journal Article
Richard S, Toussaint-Hacquard M, Fay R, Lacour JC, et al.
Molecular genetics and metabolism · 2011 · Journal Article
Arfi A, Richard M, Gandolphe C, Bonnefont-Rousselot D, et al.
Annales de cardiologie et d'angeiologie · 2010 · Journal Article
Lorgis L, Richard C, Zeller M, Gudjoncik A, et al.
Stroke · 2010 · Journal Article
Thoonsen H, Richard E, Bentham P, Gray R, et al.
Circulation · 2009 · Journal Article
Gómez AM, Rueda A, Sainte-Marie Y, Pereira L, et al.
Journal des maladies vasculaires · 2009 · Journal Article
Richard S, Toussaint-Hacquard M, Lecompte T
Gastroenterology · 2007 · Comparative Study
Hawkey CJ, Weinstein WM, Smalley W, Gitton X, et al.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2006 · Case Reports
Hender J, Harris D, Richard B, Dawson A, et al.
Coronary artery disease · 2006 · Journal Article
Isaaz K, Robin C, Cerisier A, Lamaud M, et al.
Archives des maladies du coeur et des vaisseaux · 2005 · English Abstract
Géhanne A, Shayne A, Eltchaninoff H, Gilard M, et al.
American heart journal · 2003 · Comparative Study
Simpson E, Beck C, Richard H, Eisenberg MJ, et al.
Presse medicale (Paris, France : 1983) · 2003 · Case Reports
Bosacki C, Richard O, Freycon F, Mosnier JF, et al.
Leukemia & lymphoma · 1998 · Clinical Trial
Legouffe E, Rodriguez C, Picot MC, Richard B, et al.
Annales de cardiologie et d'angeiologie · 1995 · English Abstract
Cambou JP, Amouyel P, Arveiler D, Bingham A, et al.
Archives des maladies du coeur et des vaisseaux · 1995 · English Abstract
Cambou JP, Lablache-Combier B, Marques-Vidal P, Ruidavets JB, et al.
Circulation · 1995 · Journal Article
Joannides R, Haefeli WE, Linder L, Richard V, et al.
International journal of epidemiology · 1994 · Comparative Study
Amouyel P, Arveiler D, Cambou JP, Montaye M, et al.
Frontiers in pharmacology · 2023 · Journal Article
Iacobelli S, Commins M, Lorrain S, Gouyon B, et al.
Journal of neurointerventional surgery · 2023 · Observational Study
Marnat G, Finistis S, Moreno R, Sibon I, et al.
AJNR. American journal of neuroradiology · 2022 · Journal Article
JAMA · 2025 · Journal Article
Jung B, Jabaudon M, De Jong A, Bitker L, et al.
Journal of the American Geriatrics Society · 2009 · Journal Article
Richard E, Kuiper R, Dijkgraaf MG, Van Gool WA, et al.
AJNR. American journal of neuroradiology · 2022 · Journal Article
Marnat G, Finistis S, Delvoye F, Sibon I, et al.
Circulation · 2009 · Journal Article
Eisenberg MJ, Richard PR, Libersan D, Filion KB
Lupus · 2008 · Journal Article
Belizna C, Lartigue A, Favre J, Gilbert D, et al.
Autoimmunity reviews · 2007 · Journal Article
Belizna CC, Richard V, Thuillez C, Lévesque H, et al.
The British journal of dermatology · 2026 · Journal Article
Dereure O, Bernard P, Chosidow O, Ingen-Housz-Oro S, et al.
American journal of physiology. Regulatory, integrative and comparative physiology · 2008 · Journal Article
Kolditz C, Borthaire M, Richard N, Corraze G, et al.
Fundamental & clinical pharmacology · 1992 · Comparative Study
Gao Y, Pons G, Rey E, Richard MO, et al.
AJNR. American journal of neuroradiology · 2022 · Journal Article
Marnat G, Finistis S, Delvoye F, Sibon I, et al.
Marnat G, Finistis S, Delvoye F, Sibon I, et al.
Archives of cardiovascular diseases · 2014 · Journal Article
Rangé G, Yayehd K, Belle L, Thuaire C, et al.
Alimentary pharmacology & therapeutics · 2008 · Comparative Study
Hawkey CJ, Weinstein WM, Stricker K, Murphy V, et al.
JAMA · 2005 · Clinical Trial
Beck CA, Richard H, Tu JV, Pilote L
Alimentary pharmacology & therapeutics · 2008 · Comparative Study
Hawkey CJ, Weinstein WM, Stricker K, Murphy V, et al.
Pharmacoepidemiology and drug safety · 2007 · Journal Article
Hudson M, Richard H, Pilote L