📇 Rhumatologue · BOURGOIN JALLIEU CEDEX · (38) · Libéral
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3 raisons identifiées
Praticien-chercheur
8 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
120.1 rhumatos / 100 000 hab. — département bien doté
17 publications sur 5 ans
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
7
7 articles ont été cités au moins 7fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
216
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
23
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
5
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
El pasado recobrado en la pequeña pantalla durante los procesos democratizadores en la península ibérica
2025ArticleRevista de estudios políticos
Relire les transitions ibériques à l'aune du petit écran, 1973-1982
2023Thèse
La Revolución de los Claveles vista a través de Televisión Española (Abril de 1974-abril de 1976)
2017Chapitre
El discurso de la Radiotelevisão Portuguesa sobre la conflictividad laboral durante el PREC
2017ArticleHistoria, Trabajo y Sociedad
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CH PIERRE OUDOT BOURGOIN JALLIEU
30 AV DU MEDIPOLE BP 40348, 38302 BOURGOIN JALLIEU CEDEX
CABINET DU DR VIRGINIE PHILIPPE
PLURIDISCIPLINAIRE DAUPHINE SCM MAISON DE SANTE 67 RUE DU MIDI, 38090 VILLEFONTAINE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
International journal of molecular sciences · 2024
Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage repair promotion and tissue engineering, offering key advantages such as enhanced tissue integration and therapeutic potential. This comprehensive review navigates the landscape of adhesive hydrogels in cartilage repair, discussing identified challenges, shortcomings of current treatment options, and unique advantages of adhesive hydrogel products and scaffolds. While emphasizing the critical need for in situ lateral integration with surrounding tissues, we dissect current limitations and outline future perspectives for hydrogel scaffolds in cartilage repair. Moreover, we examine the clinical translation pathway and regulatory considerations specific to adhesive hydrogels. Overall, this review synthesizes the existing insights and knowledge gaps and highlights directions for future research regarding adhesive hydrogel-based devices in advancing cartilage tissue engineering.
Cells · 2022
Cultured autologous human articular chondrocyte (HAC) implantation has been extensively investigated for safe and effective promotion of structural and functional restoration of knee cartilage lesions. HAC-based cytotherapeutic products for clinical use must be manufactured under an appropriate quality assurance system and follow good manufacturing practices (GMP). A prospective clinical trial is ongoing in the Lausanne University Hospital, where the HAC manufacturing processes have been implemented internally. Following laboratory development and in-house GMP transposition of HAC cell therapy manufacturing, a total of 47 patients have been treated to date. The main aim of the present study was to retrospectively analyze the available manufacturing records of the produced HAC-based cytotherapeutic products, outlining the inter-individual variability existing among the 47 patients regarding standardized transplant product preparation. These data were used to ameliorate and to ensure the continued high quality of cytotherapeutic care in view of further clinical investigations, based on the synthetic analyses of existing GMP records. Therefore, a renewed risk analysis-based process definition was performed, with specific focus set on process parameters, controls, targets, and acceptance criteria. Overall, high importance of the interdisciplinary collaboration and of the manufacturing process robustness was underlined, considering the high variability (i.e., quantitative, functional) existing between the treated patients and between the derived primary HAC cell types.
Cartilage · 2021
Objective A pivotal aspect of cartilage tissue engineering resides in cell culture medium supplementation, in view of maximizing in vitro cell proliferation and preserving cellular functionality. Autologous human serum (aHS) is commonly used as an inducive supplement for safe human articular chondrocyte (HAC) proliferation prior to clinical implantation. However, practical clinical use of aHS is hindered by constraining manufacturing requirements and quality assurance-driven downstream processing. The present study investigated potential alternative use of commercial human platelet lysate (hPL) supplements in HAC manufacturing workflows related to clinical therapeutic pathways. Design Differential effects of hPL, aHS, and fetal bovine serum were assessed on primary cultured HAC parameters (viability, proliferative rates, and morphology) in 2-dimensional in vitro systems. A 3-dimensional HAC pellet model served for postexpansion assessment of cellular functionality, by visualizing proteoglycan production (Alcian blue staining), and by using qRT-PCR relative quantification of chondrogenic marker ( SOX9, COL2-A1, and ACAN) genetic expression. Results We found that monolayer HAC culture with hPL or aHS supplements presented similar characteristics (elongated cell morphology and nearly identical growth kinetics). Chondrogenic activity appeared as conserved in HACs expanded with human or bovine supplements, wherein histologic analysis indicated a progressive sGAG accumulation and SOX9, COL2-A1, ACAN gene expression was upregulated in 3-dimensional HAC pellet models. Conclusion This study therefore supports the use of hPL as a functional equivalent and alternative to aHS for cultured HAC batch preparation, with the potential to effectively alleviate pressure on clinical and manufacturing bottlenecks in cell therapy approaches for cartilage regeneration.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Frontiers in bioengineering and biotechnology · 2026 · Journal Article
Karami P, Martin R, Laurent A, Philippe V, et al.
Gels (Basel, Switzerland) · 2024 · Journal Article
Karami P, Martin R, Laurent A, Nam HY, et al.
International journal of molecular sciences · 2024 · Journal Article
Karami P, Laurent A, Philippe V, Applegate LA, et al.
Orthopaedic journal of sports medicine · 2024 · Journal Article
Schneebeli V, Philippe V, Laurent A, Applegate LA, et al.
Pharmaceutics · 2023 · Journal Article
Philippe V, Jeannerat A, Peneveyre C, Jaccoud S, et al.
Revue medicale suisse · 2022 · English Abstract
Martin R, Laurent A, Applegate LA, Philippe V
Cells · 2022 · Journal Article
Philippe V, Laurent A, Hirt-Burri N, Abdel-Sayed P, et al.
Cartilage · 2021 · Journal Article
Philippe V, Laurent A, Abdel-Sayed P, Hirt-Burri N, et al.
Human Platelet Lysate as an Alternative to Autologous Serum for Human Chondrocyte Clinical Use
ObjectiveA pivotal aspect of cartilage tissue engineering resides in cell culture medium supplementation, in view of maximizing <i>in vitro</i> cell proliferation and preserving cellular functionality. Autologous human s
Human Platelet Lysate as an Alternative to Autologous Serum for Human Chondrocyte Clinical Use
ObjectiveA pivotal aspect of cartilage tissue engineering resides in cell culture medium supplementation, in view of maximizing <i>in vitro</i> cell proliferation and preserving cellular functionality. Autologous human s
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).