📇 Rhumatologue · CHAMPIGNE · (49) · Libéral
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2 raisons identifiées
Auteur de référence en rhumatologie
38 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
121.5 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR JEAN-LUC PEREIRA
14 RUE CHARLES DE GAULLE, 49330 CHAMPIGNE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Clinical reviews in allergy & immunology · 2016
The Lancet. Haematology · 2017
The Journal of experimental medicine · 2015
Bone surfaces attract hematopoietic and nonhematopoietic cells, such as osteoclasts (OCs) and osteoblasts (OBs), and are targeted by bone metastatic cancers. However, the mechanisms guiding cells toward bone surfaces are essentially unknown. Here, we show that the Gαi protein–coupled receptor (GPCR) EBI2 is expressed in mouse monocyte/OC precursors (OCPs) and its oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) is secreted abundantly by OBs. Using in vitro time-lapse microscopy and intravital two-photon microscopy, we show that EBI2 enhances the development of large OCs by promoting OCP motility, thus facilitating cell–cell interactions and fusion in vitro and in vivo. EBI2 is also necessary and sufficient for guiding OCPs toward bone surfaces. Interestingly, OCPs also secrete 7α,25-OHC, which promotes autocrine EBI2 signaling and reduces OCP migration toward bone surfaces in vivo. Defective EBI2 signaling led to increased bone mass in male mice and protected female mice from age- and estrogen deficiency–induced osteoporosis. This study identifies a novel pathway involved in OCP homing to the bone surface that may have significant therapeutic potential.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Pulmonology · 2025 · Journal Article
Morais A, Duarte AC, Fernandes MO, Borba A, et al.
Climacteric : the journal of the International Menopause Society · 2025 · Journal Article
Jacques LS, Pereira JPC, Santos BM, Barrioni BR, et al.
Veterinary journal (London, England : 1997) · 2025 · Journal Article
Costa L, Tomé I, Colaço B, Alves-Pimenta S, et al.
IJU case reports · 2024 · Case Reports
André M, Macedo A, Metrogos V, Moreira L, et al.
Veterinary sciences · 2024 · Journal Article
Tomé I, Costa L, Alves-Pimenta S, Sargo R, et al.
PloS one · 2023 · Journal Article
Tomé I, Alves-Pimenta S, Costa L, Pereira J, et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022 · Journal Article
Dassieu L, Choinière M, Saint-Jean L, Webster F, et al.
ARP rheumatology · 2022 · Journal Article
Fernandes BM, Guimarães F, Almeida DE, Neto A, et al.
Biomechanics and modeling in mechanobiology · 2020 · Journal Article
Ashrafi M, Gubaua JE, Pereira JT, Gahlichi F, et al.
Clinical case reports · 2020 · Case Reports
Pedro J, Belo S, Guerreiro V, Ferreira MJ, et al.
Biomechanics and modeling in mechanobiology · 2020 · Journal Article
Saeidi M, Gubaua JE, Kelly P, Kazemi M, et al.
Scientific reports · 2019 · Journal Article
Lemos FS, Pereira JX, Carvalho VF, Bernardes ES, et al.
International journal of rheumatic diseases · 2019 · Journal Article
Bernardes M, Madureira A, Oliveira A, Martins MJ, et al.
Acta reumatologica portuguesa · 2019 · Journal Article
Carvalho J, Vieira AC, Ferra J, Novais E Bastos H, et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018 · Journal Article
Bernardes M, Durães C, Oliveira A, Martins MJ, et al.
Rheumatology international · 2017 · Journal Article
Bernardes M, Vieira T, Lucas R, Pereira J, et al.
Journal of orthopaedic case reports · 2017 · Case Reports
Pereira J, Anoop S, Pettah GJ
European journal of case reports in internal medicine · 2016 · Journal Article
Pereira J, Eugénio G, Calretas S, Santos R, et al.
The Journal of experimental medicine · 2015 · Journal Article
Nevius E, Pinho F, Dhodapkar M, Jin H, et al.
BMC veterinary research · 2023 · Journal Article
Tomé I, Alves-Pimenta S, Sargo R, Pereira J, et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2023 · Meta-Analysis
Batista NVR, Valdez RMA, Silva EMVM, Melo TS, et al.
Cureus · 2021 · Case Reports
Seixas R, Lopes D, Couto M, Pereira J, et al.
Cureus · 2024 · Case Reports
Pinto A, Pereira J, Caneira F, Garcao D, et al.
Cureus · 2021 · Case Reports
Seixas R, Lopes D, Couto M, Pereira J, et al.
BMJ open · 2025 · Journal Article
Tunas-Maceiras I, Pereira J, Pértega Díaz S, López Campos JÁ, et al.
The Lancet. Rheumatology · 2023 · Randomized Controlled Trial
Rivellese F, Nerviani A, Giorli G, Warren L, et al.
Trials · 2024 · Equivalence Trial
Richter A, Truthmann J, Hummers E, Pereira JFM, et al.
European journal of nuclear medicine and molecular imaging · 2016 · Case Reports
Fernandes A, Faria MT, Oliveira A, Vieira T, et al.
The Journal of rheumatology · 2022 · Journal Article
Fernandes BM, Pereira JM, Pereira PR, Bernardes M
Journal of pharmacokinetics and pharmacodynamics · 2024 · Journal Article
Pereira JNS, Ottevaere I, Serruys B, Guehring H, et al.
The Lancet. Haematology · 2017 · Clinical Trial, Phase III
Jurczak W, Moreira I, Kanakasetty GB, Munhoz E, et al.
Hematology, transfusion and cell therapy · 2021 · Journal Article
Sarmiento M, Jara V, Soto K, Uribe P, et al.
Drugs & aging · 2020 · Journal Article
Freitas R, Godinho F, Madeira N, Fernandes BM, et al.
JCI insight · 2024 · Journal Article
Stabach PR, Sims D, Gomez-Bañuelos E, Zehentmeier S, et al.
The Journal of rheumatology · 2022 · Journal Article
Fernandes BM, Pereira JM, Pereira PR, Bernardes M
Clinical rheumatology · 2017 · Journal Article
Martins NFE, Seixas MI, Pereira JP, Costa MM, et al.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2018 · Case Reports
Nogueira H, Pereira J, Couto A, Alves J, et al.
Drugs & aging · 2020 · Journal Article
Freitas R, Godinho F, Madeira N, Fernandes BM, et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2023 · Meta-Analysis
Batista NVR, Valdez RMA, Silva EMVM, Melo TS, et al.
Multiple sclerosis and related disorders · 2016 · Case Reports
Pinho J, Rocha J, Sousa F, Macedo C, et al.
Drugs & aging · 2020 · Journal Article
Freitas R, Godinho F, Madeira N, Fernandes BM, et al.
Acta medica portuguesa · 2016 · Journal Article
Morais A, Resende M, Pereira J
Clinical reviews in allergy & immunology · 2016 · Journal Article
Nevius E, Gomes AC, Pereira JP