📇 Rhumatologue · PARIS · (75) · Libéral

M ANTOINE ORSATELLI

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23 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 PARIS (75)LibéralRPPS 10001354066

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Top publications · les plus citées

Performance Study of Noninvasive Salivary Biomarkers in Laryngopharyngeal Reflux

The journal of applied laboratory medicine · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

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Abstract Background The diagnosis of laryngopharyngeal reflux disease (LPRD) mostly uses invasive techniques. Our aim was to carry out a performance study of noninvasive saliva biomarkers in LPRD patients and to investigate clinical utility. Methods The saliva of 201 patients with an LPRD diagnosis was prospectively collected using a Salivette® device. Findings were compared with 35 healthy controls using nonparametric statistics. Biomarker cut-offs were determined with receiver operating curves (ROCs). Results The analytical performance study indicated satisfactory performance against biological acceptability goals for bias, imprecision, and total allowable error. The limit of detection (LOD) was evaluated for all biomarkers in the saliva matrix. Results fell within the analytical measurement range for salivary elastase, trypsin, and pH and close to the LOD for cholesterol. The clinical study reported significantly higher salivary pH and elastase and lower cholesterol in LPRD compared to controls (P &lt; 0.05), while salivary trypsin did not differ significantly. Diagnostic cut-offs determined with ROC were salivary elastase &gt;49 µg/mL, salivary pH &gt;7.6, and salivary cholesterol &lt;2.1 mg/dL (&lt;0.054 mmol/L). The combination of salivary elastase with cholesterol gave a positive predictive value of 93% and a negative predictive value of 100% for the diagnosis of LPRD in this study. Salivary total bilirubin, lipase, and pepsin were mostly undetected. Conclusions Noninvasive diagnosis of LPRD is possible, based on a single saliva collection, although our cut-offs should be evaluated in further studies. A reproducible analytical protocol has been obtained. Salivary elastase, cholesterol, and pH show clinical utility for the presence of duodeno-gastric reflux in LPRD patients.

Emotion Regulation Interventions for Cancer Patients and Their Relatives: A Systematic Review

Cancer medicine · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

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ABSTRACT Background Emotional regulation (ER) is crucial for the psychological well‐being of patients with cancer and their relatives. Various ER interventions exist but often suffer from poor adherence and high attrition rates. Aims This systematic review aims to identify ER interventions for patients with cancer and their relatives, describe their content, development, and evaluation methods, and assess their efficacy on ER and psychological health outcomes. Methods Cochrane, Embase, PsycArticles, PsycINFO, and Web of Science databases were searched. Eligible studies examined individual interventions targeting ER (Intervention) in adult patients with cancer and their relatives (Population), included a control group or a pre–post assessment (Comparator), and reported outcomes related to ER or psychological health outcomes using quantitative or mixed‐method results (Study type). Results Eight studies were included. Most interventions were theoretically grounded in cognitive behavioral therapy (CBT) and followed a similar structure: informational sessions, skill‐building modules using targeted therapeutic techniques, and consolidation via homework and relapse‐prevention exercises. Despite high attrition rates, most interventions significantly improved ER and psychological outcomes. Some trials lacked statistical significance, mainly due to methodological limitations. Although acceptability was rarely assessed, evidence suggests patient–relatives dyadic approaches may better meet participant needs. Conclusion ER interventions share common features and show effectiveness but sometimes lack alignment between objectives and evaluated outcomes. Retention remains a major challenge, emphasizing the need to redesign interventions and their implementation. Future research should explore attrition causes and develop strategies to enhance engagement.

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Publications scientifiques (23) — classées par pathologie

Transversal12

Revue générale5

Revue / méta-analyse4

Qualité de vie / PROMs3

Génétique2

Gériatrie2

Biomarqueurs / Auto-Ac1

Essai clinique1

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