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3 raisons identifiées
Auteur de référence en rhumatologie
36 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
105.7 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CL DU SUD CARCASSONNE
LA MADELEINE HAM MONTREDON, 11000 CARCASSONNE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 L'Indépendant · 22/02/2024
<a href="https://news.google.com/rss/articles/CBMizgFBVV95cUxOWXJlSGlsbmt0OEpuTHFYNEdmN3F6YXkzSVFMY0NKcFY1MWpiYUFDRUVSLUMybmp5NEtpOHYwWVJYSkRyUUY0M0hCRnVHOXdDN2dhR3h1bHdEMFZWc0owekx0ZGp3dFhjNE1ycXd6MnBGSE50Ukd4bG45UzEtdHpQOUc2SmE2aXZ5RnRSMHA4YTM5dmxER0swQjI1UXpOdXktS3lzS3FPdFBJMF9TSlhzWm9KbHdxV1JxUH
International journal of oral and maxillofacial surgery · 2023
Acta neurochirurgica · 2024
Genome medicine · 2025
Abstract Background Acute sinusitis (AS) is a frequent cause of antibiotic prescriptions in children. Distinguishing bacterial AS from common viral upper respiratory infections (URIs) is crucial to prevent unnecessary antibiotic use but is challenging with current diagnostic methods. Despite its speed and cost, untargeted RNA sequencing of clinical samples from children with suspected AS has the potential to overcome several limitations of other methods. In addition, RNA-seq may reveal novel host-response biomarkers for development of future diagnostic assays that distinguish bacterial from viral infections. There are however no available RNA-seq datasets of pediatric AS that provide a comprehensive view of both pathogen etiology and host immune response. Methods Here, we performed untargeted RNA-seq (metatranscriptomics) of nasopharyngeal samples from 221 children with AS and performed a comprehensive analysis of pathogen etiology and the impact of bacterial and viral infections on host immune responses. Accuracy of RNA-seq-based pathogen detection was evaluated by comparison with culture tests for three common bacterial pathogens and qRT-PCR tests for 12 respiratory viruses. Host gene expression patterns were explored to identify potential host responses that distinguish bacterial from viral infections. Results RNA-seq-based pathogen detection showed high concordance with culture or qRT-PCR, showing 87%/81% sensitivity (sens) / specificity (spec) for detecting three AS-associated bacterial pathogens, and 86%/92% (sens/spec) for detecting 12 URI-associated viruses, respectively. RNA-seq also detected an additional 22 pathogens not tested for clinically and identified plausible pathogens in 11/19 (58%) of cases where no organism was detected by culture or qRT-PCR. We reconstructed genomes of 196 viruses across the samples including novel strains of coronaviruses, respiratory syncytial virus, and enterovirus D68, which provide useful genomic data for ongoing pathogen surveillance programs. By analyzing host gene expression, we identified host-response signatures that differentiate bacterial and viral infections, revealing hundreds of candidate gene biomarkers for future diagnostic assays. Conclusions Our study provides a one-of-kind dataset that profiles the interplay between pathogen infection and host responses in pediatric AS and URI. It reveals bacterial and viral-specific host responses that could enable new diagnostic approaches and demonstrates the potential of untargeted RNA-seq in diagnostic analysis of AS and URI.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
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International journal of psychiatry in medicine · 2025 · Journal Article
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Cornea · 2024 · Journal Article
Prescott CR, Cohen EJ, Hochman JS, Troxel AB, et al.
Acta neurochirurgica · 2024 · Journal Article
Choucha A, Troude L, Morin L, Fernandes S, et al.
Brain, behavior, & immunity - health · 2023 · Journal Article
Graïc JM, Finos L, Vadori V, Cozzi B, et al.
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Morita D, Mazen S, Tsujiko S, Otake Y, et al.
PLoS neglected tropical diseases · 2023 · Journal Article
Guttapadu R, Prakash N, M A, Chatterjee R, et al.
medRxiv : the preprint server for health sciences · 2022 · Preprint
Ghosh P, Niesen MJM, Pawlowski C, Bandi H, et al.
Physiotherapy · 2026 · Letter
Rashid FA, M RP
BMC musculoskeletal disorders · 2025 · Journal Article
Elsayed M, Khalefa AH, Mazen MSH, Ahmed KFE
Annals of rehabilitation medicine · 2025 · Journal Article
Moustafa EBS, Darwish MH, El-Tamawy MS, Mazen MM, et al.
American journal of physical medicine & rehabilitation · 2023 · Randomized Controlled Trial
BMC microbiology · 2026 · Journal Article
Ibrahim A, Mazen MAI, Eltaweel D, Salam SMAE, et al.
Genome medicine · 2025 · Journal Article
Doxey AC, Abu Mazen N, Homm M, Chu V, et al.
Clinical rheumatology · 2025 · Journal Article
Mohan A, Mohan A, Ramachandran A, Pulinilkunnathil JG, et al.
Clinical rheumatology · 2025 · Journal Article
A K, M EA, M H, H A, et al.
Rheumatology and immunology research · 2024 · Journal Article
Datta D, Khatun M, Bankura B, Sarkar M, et al.
Cureus · 2026 · Case Reports
Elfatih Mohamed M, Mazen Y, Saleh Shehadeh C, Hussein S, et al.
Cureus · 2025 · Case Reports
Mazen Y, Darweesh A, Al Ani M, Alfalasi N, et al.
Endocrine connections · 2026 · Journal Article
Roxas A, Gihawi A, Makarchuk M, Bryce J, et al.
American journal of physical medicine & rehabilitation · 2023 · Randomized Controlled Trial
ElGendy MH, Mazen MM, Saied AM, ElMeligie MM, et al.
Cureus · 2024 · Case Reports
Surapaneni D, Dasi SC, Sam N, M J
JMIR research protocols · 2025 · Journal Article
M A, Ahmad A, A A, Raj LS, et al.
BMJ case reports · 2025 · Journal Article
Pathrot D, Nachappa AA, Mannual S, M SK
Indian journal of dermatology, venereology and leprology · 2023 · Letter
Rao AG, M N, Ch S, Jhawar J
Radiology case reports · 2023 · Case Reports
Lee ZR, Lai YK, M L, Khor LY, et al.
Genome medicine · 2025 · Journal Article
Doxey AC, Abu Mazen N, Homm M, Chu V, et al.
Cureus · 2025 · Journal Article
Nallaperumal S, V P, M C V, Pusapati LCV, et al.
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Mazen IH, El-Gammal MA, Elaidy AA, Anwar GM, et al.
Cureus · 2024 · Case Reports
Mohan A, Kuriakose SM, James L, G BT, et al.
JACC. Case reports · 2024 · Case Reports
Kharge JL, M UK, M L J, Newaskar AA, et al.
Cureus · 2023 · Journal Article
M D, Kumar J, Ramalingam K
ElGendy MH, Mazen MM, Saied AM, ElMeligie MM, et al.