M DIDIER NOEL

Rhumatologue

RPPS 10000667005

📊 Reconnaissance scientifique : 4/100📝 19 articles publiés🇫🇷 Publications académiques françaises (7)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

4 articles ont été cités au moins 4fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (5)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

➤ Pour le Dr Noël, de l’hôpital de Valence : « C’est une sage décision » - Le Dauphiné Libéré

📰 Le Dauphiné Libéré · 31/03/2021

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Forbach : Un laboratoire dédié aux troubles du sommeil - Le Republicain Lorrain

📰 Le Republicain Lorrain · 26/03/2017

<a href="https://news.google.com/rss/articles/CBMiuAFBVV95cUxNeUszMmVmaE9YbTBQdi1VSnVFX3ZKYTdVbkFlQlhsVHQzSDhVNHNaZjhMWXZBTlRURl8xUm1FV0NvdDI1STdtWksydkVRUm5KQTNhWi1HaERtY2FHSF9rbWhDWXJDamtNejN4M25rcnRnOG85enA2WWREYUhNRnFDNUhWQ2NPaTM2T3hibUc0M2hMSUhrX2l3VWc5eEs0Z0tnZExWaUFwa1RGVDFTakg0WFY5UU1zay1s?o

Deux nouveaux internes en poste aux urgences et en médecine générale à La Ferté-Macé - Actu.fr

📰 Actu.fr · 10/05/2018

<a href="https://news.google.com/rss/articles/CBMizAFBVV95cUxOaGJ0Y2NtTzlKTTRKSGFwcXNRTnpfLVo2dXROQmJEMElwOW5lX0p6VklQcHlad0YzWWJyWDEtS3R0b1MzRTZFdWduUGxfVG1tT20zQ0Q5LWVqeDU2Uk1XNG1icnVFNE9vZnlJckJTdm5Bb2NZQnJNaEtrRWxQSTlIS2RYZFpFX3NCSHFqcEFVMnNlVkVaX1BoaFUtcnh3SDB5cGF0bkNIcF9fQVpVV2d0Z3pRekkyZWhhQX

Santé. La Région offre des oxymètres aux hôpitaux de Valence et Montélimar - Le Dauphiné Libéré

📰 Le Dauphiné Libéré · 03/12/2020

<a href="https://news.google.com/rss/articles/CBMisAFBVV95cUxOODMyVndFQXpUQ0lXWnZoMHRfc0dqOGZpYjUtWDBuX1NQZDNidUdFcnhxMHUwbV9jWU9TemhBdFdmX29YbDFSRVRjRElvMllLdl95eUh0aU9DWTltdEQ3cWxqaXEzbi1qWXg4YVhqWEljcElocExRanFJR25GWHBqZlJxanQ5WEV4YzVmTzlmNTdMalN5YzJfanRBbVhkcjNSTnZCR0FxOE95bEFzU3dqXw?oc=5" targe

Moselle. La région de Forbach particulièrement touchée par la BPCO, une maladie respiratoire chronique - Le Republicain Lorrain

📰 Le Republicain Lorrain · 21/11/2024

<a href="https://news.google.com/rss/articles/CBMi3AFBVV95cUxPakdVU09kN3NqQjdYR0sxVEx5N3QwS1BVS3Q2bnRvQ1h1TUhQczhIWmhNOTg0Z0IxWWxDYV8teVEycWdRU3J4czBUdVdMbmRTVkRVSVE0bnhqaGNyQVAwNV9wbnFXZ0hxVlluWXh0aHlJa3JzZHM2ZU9fVHlYblZwVWhDb0NPVkpqTmZTQ0RYT0o2cWQzYng3QWpNXzBmZ203Ym5YbE82bThjS0tGbk1rVjB4LWdoT1NkeT

Top publications · les plus citées

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Scientific reports · 2017

📚 491 citations🎯 RCR 21.86Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractMesenchymal stem or stromal cells (MSCs) exert chondroprotective effects in preclinical models of osteoarthritis (OA). Most of their therapeutic effects are mediated via soluble mediators, which can be conveyed within extracellular vesicles (EVs). The objective of the study was to compare the respective role of exosomes (Exos) or microvesicles/microparticles (MPs) in OA. MPs and Exos were isolated from bone marrow murine BM-MSCs through differential centrifugation. Effect of MPs or Exos was evaluated on OA-like murine chondrocytes and chondroprotection was quantified by RT-qPCR. In OA-like chondrocytes, BM-MSC-derived MPs and Exos could reinduce the expression of chondrocyte markers (type II collagen, aggrecan) while inhibiting catabolic (MMP-13, ADAMTS5) and inflammatory (iNOS) markers. Exos and MPs were also shown to protect chondrocytes from apoptosis and to inhibit macrophage activation. In vivo, Exos or MPs were injected in the collagenase-induced OA (CIOA) model and histomorphometric analyses of joints were performed by µCT and confocal laser microscopy. BM-MSCs, MPs and Exos equally protected mice from joint damage. In conclusion, MPs and Exos exerted similar chondroprotective and anti-inflammatory function in vitro and protected mice from developing OA in vivo, suggesting that either Exos or MPs reproduced the main therapeutic effect of BM-MSCs.

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

Stem cells translational medicine · 2016

📚 352 citations🎯 RCR 16.69Top 1% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was conducted in France and Germany with regulatory agency approval for ASC expansion procedure in both countries. From April 2012 to December 2013, 18 consecutive patients with symptomatic and severe knee OA were treated with a single intra-articular injection of autologous ASCs. The study design consisted of three consecutive cohorts (six patients each) with dose escalation: low dose (2 × 106 cells), medium dose (10 × 106), and high dose (50 × 106). The primary outcome parameter was safety evaluated by recording adverse events throughout the trial, and secondary parameters were pain and function subscales of the Western Ontario and McMaster Universities Arthritis Index. After 6 months of follow-up, the procedure was found to be safe, and no serious adverse events were reported. Four patients experienced transient knee joint pain and swelling after local injection. Interestingly, patients treated with low-dose ASCs experienced significant improvements in pain levels and function compared with baseline. Our data suggest that the intra-articular injection of ASCs is a safe therapeutic alternative to treat severe knee OA patients. A placebo-controlled double-blind phase IIb study is being initiated to assess clinical and structural efficacy. Significance Although this phase I study included a limited number of patients without a placebo arm, it showed that local injection of autologous adipose-derived stem cells was safe and well tolerated in patients with knee osteoarthritis. This study also provides encouraging preliminary evidence of efficacy. Larger and controlled long-term studies are now mandatory to confirm whether this new strategy of cell therapy can improve pain and induce structural benefit in osteoarthritis.

PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis

Biomaterials · 2016

📚 72 citations🎯 RCR 3.59Top 13% NIH

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Publications scientifiques (27) — classées par pathologie

Transversal20

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