Docteur GAETANE NOCTURNE
✨ Profil synthétique
IA · 04/05/2026Le Docteur Gaetane Nocturne est un rhumatologue hospitalier au Kremlin-Bicêtre avec une expertise dans la recherche sur les maladies rhumatismales, notamment le lupus érythémateux systémique et la sclérose systémique. Ses travaux de recherche portent également sur les troubles des glandes salivaires et les thérapies contre l'arthrite rhumatoïde. Avec un h-index de 34 et 257 publications, il a dirigé plusieurs thèses en immunologie et biologie moléculaire.
Expertises présumées
- Sjögren
- Lupus érythémateux systémique
- Sclérose systémique
- Arthrite rhumatoïde
- Thérapies ciblées JAK
- Biothérapies non-anti-TNF
- csDMARDs
- Immunologie en rhumatologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Direction de thèses
🎓 4 thèses dirigéesApproches de biologie computationnelle des systèmes pour dévoiler les interactions moléculaires dans la pathogénèse de la maladie de Sjögren
2025Doctorant·e : Sacha E silva--saffar
Biologie moléculaire et cellulaire🎓 université Paris-SaclayDéveloppement d'organoïdes de glande salivaire dans la maladie de Sjögren : un outil innovant pour l'étude de la maladie et l'identification de nouvelles thérapies ciblées
2024Doctorant·e : Loïc Meudec
Immunologie🎓 université Paris-SaclayRôle des cellules épithéliales salivaires au cours du Syndrome de Sjögren primitif
2020Doctorant·e : Élodie Rivière
Immunologie🎓 université Paris-SaclayDéveloppement d'immuno-organoïdes pour étudier les maladies auto-immunes - maladie de Sjögren et syndrome sec induit par l'immunothérapie du cancer
Doctorant·e : Zahra Goudarzi
Immunologie🎓 université Paris-Saclay
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
34
h articles cités ≥ h fois chacun. Un h de 34 = 34 publications avec 34+ citations.
Citations
5 210
Publications
257
i10-index
83
Thématiques principales
- Salivary Gland Disorders and Functions ×132
- Rheumatoid Arthritis Research and Therapies ×44
- Systemic Lupus Erythematosus Research ×42
- Lymphoma Diagnosis and Treatment ×29
- Systemic Sclerosis and Related Diseases ×28
Affiliations FR : Université Paris-Sud · Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
The immune cell landscape analyzed by imaging mass cytometry in the muscle of patients with inclusion body myositis associated or not with Sjögren’s disease
2026ArticleRheumatology
A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
2026ArticleAnnals of the Rheumatic Diseases
Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
2025ArticleThe Lancet Rheumatology
Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren’s disease
2025ArticleAnnals of the Rheumatic Diseases
French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases
2025ArticleJoint Bone Spine
The role of dental professionals in identifying patients with a suspected primary Sjögren's syndrome and suggestions for prevention and treatment of oral complications: a narrative review
2025ArticleHeliyon
Primary Sjögren’s Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI)
2025ArticleAnnals of the Rheumatic Diseases
CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
2025ArticleThe Lancet Rheumatology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
GHU APHP UPS SITE KREMLIN BICETRE APHP
78 Avenue DU GENERAL LECLERC, 94275 Le Kremlin-Bicêtre
☎ 0145212121Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts
The Lancet. Rheumatology · 2024
📚 56 citations🎯 RCR 13.68Top 2% NIH🔓 Open Access - 2CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
The Lancet. Rheumatology · 2025
📚 28 citations🎯 RCR 10.18 - 3Liposomal AntagomiR-155-5p Restores Anti-Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis
Arthritis & rheumatology (Hoboken, N.J.) · 2024
Lire l'abstract Crossref ↓
ObjectiveWe previously reported an increased expression of microRNA‐155 (miR‐155) in the blood monocytes of patients with rheumatoid arthritis (RA) that could be responsible for impaired monocyte polarization to anti‐inflammatory M2‐like macrophages. In this study, we employed two preclinical models of RA, collagen‐induced arthritis and K/BxN serum transfer arthritis, to examine the therapeutic potential of antagomiR‐155‐5p entrapped within PEGylated (polyethylene glycol [PEG]) liposomes in resolution of arthritis and repolarization of monocytes towards the anti‐inflammatory M2 phenotype.MethodsAntagomiR‐155‐5p or antagomiR‐control were encapsulated in PEG liposomes of 100 nm in size and −10 mV in zeta potential with high antagomiR loading efficiency (above 80%). Mice were injected intravenously with 1.5 nmol/100 μL PEG liposomes containing antagomiR‐155‐5p or control after the induction of arthritis.ResultsWe demonstrated the biodistribution of fluorescently tagged PEG liposomes to inflamed joints one hour after the injection of fluorescently tagged PEG liposomes, as well as the liver's subsequent accumulation after 48 hours, indicative of hepatic clearance, in mice with arthritis. The injection of PEG liposomes containing antagomiR‐155‐5p decreased arthritis score and paw swelling compared with PEG liposomes containing antagomiR‐control or the systemic delivery of free antagomiR‐155‐5p. Moreover, treatment with PEG liposomes containing antagomiR‐155‐5p led to the restoration of bone marrow monocyte defects in anti‐inflammatory macrophage differentiation without any significant functional change in other immune cells, including splenic B and T cells.ConclusionThe injection of antagomiR‐155‐5p encapsulated in PEG liposomes allows the delivery of small RNA to monocytes and macrophages and reduces joint inflammation in murine models of RA, providing a promising strategy in human disease.image
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Sjögren30
▼
Sjögren30
▼- The SjD Map: an interactive pathway tour into Sjögren's disease signalling mechanisms
NPJ systems biology and applications · 2026 · Journal Article
E Silva-Saffar S, Mariette X, Gottenberg JE, Bombardieri M, et al.
- Update on the Aetiopathogenesis of Sjögren Disease: From Interferon Signaling to Epithelial Dysfunction
Journal of clinical medicine · 2026 · Journal Article
Meudec L, Nocturne G, Mariette X
- The immune cell landscape analysed by imaging mass cytometry in the muscle of patients with inclusion body myositis associated or not with Sjögren's disease
Rheumatology (Oxford, England) · 2026 · Journal Article
Quéré B, Bourhis A, Hemon P, Pers JO, et al.
- Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren's disease
Current opinion in immunology · 2026 · Journal Article
Yang T, Goudarzi N, Kroese FGM, Mariette X, et al.
- A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
Annals of the rheumatic diseases · 2026 · Journal Article
Beydon M, Dulin M, Ly B, Verstuyft C, et al.
- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
- Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
The Lancet. Rheumatology · 2025 · Journal Article
Duquesne J, Basseto L, Claye C, Barnes M, et al.
📚 4 cit. - Association between anti-SSA/SSB antibody profiles and patient-reported outcomes in primary Sjögren's disease
Rheumatology (Oxford, England) · 2025 · Journal Article
Robert M, Nguyen Y, Belkhir R, Desmoulins F, et al.
- Primary Sjögren's Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren's Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI)
Annals of the rheumatic diseases · 2025 · Journal Article
Bowman SJ, Seror R, Porcher R, Arends S, et al.
📚 10 cit.🎯 RCR 4.23 - Development of salivary gland organoids derived from patient biopsies: a functional model of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Meudec L, Goudarzi N, Silva-Saffar SE, Pascaud J, et al.
📚 5 cit.🎯 RCR 1.98 - Distinct Pathophysiologic Pathways Support Stratification of Sjögren's Disease Based on Symptoms, Clinical, and Routine Biological Data
Arthritis & rheumatology (Hoboken, N.J.) · 2025 · Journal Article
Nguyen Y, Beydon M, Gottenberg JE, Morel J, et al.
📚 12 cit.🎯 RCR 4.86 - ["MALT lymphoma in Sjögren disease: To treat or not to treat?": The pros]
La Revue de medecine interne · 2025 · Journal Article
Nocturne G
- Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis
Rheumatology (Oxford, England) · 2025 · Journal Article
Astouati Q, Machet T, Houssais C, Noury JB, et al.
📚 6 cit.🎯 RCR 2.59 - Impact of Sjögren's disease on quality of sexual life using the Qualisex score
RMD open · 2025 · Journal Article
Kachaner A, Seror R, Le Guern V, Dieudé P, et al.
- Development of a web-based ecological momentary assessment tool to measure day-to-day variability of the symptoms in patients with Sjögren's disease
RMD open · 2024 · Journal Article
Georgel L, Benyoussef AA, Berrouiguet S, Guellec D, et al.
📚 2 cit.🩺 Clinique - Treatment modalities of marginal zone lymphoma and overall survival, haematological response, and underlying Sjögren's disease activity: a multicentre, retrospective, observational study
The Lancet. Rheumatology · 2024 · Journal Article
Rocca J, Beydon M, Le Guern V, Hachulla E, et al.
📚 10 cit.🎯 RCR 2.20🩺 Clinique - m(6)A RNA methylation controls salivary gland epithelial cell function and has a protective role in Sjögren's disease
Annals of the rheumatic diseases · 2024 · Journal Article
Truffinet F, Arco-Hierves A, Shalabi H, Pascaud J, et al.
📚 16 cit.🎯 RCR 2.87 - Clinical, biological, prognostic characteristics of patients with immune-mediated thrombotic thrombocytopenic purpura and Sjögren's disease
RMD open · 2024 · Journal Article
Luciano J, Gilardin L, Nocturne G, Bouzid R, et al.
📚 1 cit. - Immune Checkpoint Inhibitor-induced Sicca Syndrome
Rheumatic diseases clinics of North America · 2024 · Journal Article
Bitoun S, Rousseau A, Gosset M, Belkhir R, et al.
📚 4 cit. - Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts
The Lancet. Rheumatology · 2024 · Journal Article
Nguyen Y, Nocturne G, Henry J, Ng WF, et al.
📚 56 cit.🎯 RCR 13.68🔬→🩺 Translationnel - Characterisation of airway disease associated with Sjögren disease
RMD open · 2024 · Journal Article
Meudec L, Debray MP, Beurnier A, Marques C, et al.
📚 3 cit.🎯 RCR 1.04 - Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52 - Expert Perspective: Challenges in Sjögren's Disease
Arthritis & rheumatology (Hoboken, N.J.) · 2023 · Journal Article
Nocturne G, Mariette X
📚 3 cit. - Comparison between primary Sjögren's disease patients with high or low level of dryness
RMD open · 2023 · Journal Article
Kachaner A, Bergé E, Desmoulins F, Le Pajolec C, et al.
📚 2 cit. - Association Between Bruton's Tyrosine Kinase Gene Overexpression and Risk of Lymphoma in Primary Sjögren's Syndrome
Arthritis & rheumatology (Hoboken, N.J.) · 2023 · Journal Article
Duret PM, Schleiss C, Kawka L, Meyer N, et al.
📚 13 cit.🎯 RCR 1.33 - Efficacy of daratumumab in refractory primary Sjögren disease
RMD open · 2023 · Letter
Nocturne G, Marmontel O, di Filippo M, Chretien P, et al.
📚 14 cit.🎯 RCR 1.58🔬→🩺 Translationnel - French national diagnostic and care protocol for Sjögren's disease
La Revue de medecine interne · 2023 · Journal Article
Devauchelle-Pensec V, Mariette X, Benyoussef AA, Boisrame S, et al.
📚 11 cit.🎯 RCR 1.98🔬→🩺 Translationnel - Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study
The Lancet. Rheumatology · 2023 · Multicenter Study
de Frémont GM, Costedoat-Chalumeau N, Lazaro E, Belkhir R, et al.
📚 23 cit.🎯 RCR 4.13🔬→🩺 Translationnel - Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren's syndrome
Clinical and experimental immunology · 2023 · Journal Article
Rivière E, Chivasso C, Pascaud J, Bechara R, et al.
📚 10 cit.🎯 RCR 1.36 - Impact of patient ancestry on heterogeneity of Sjögren's disease
RMD open · 2023 · Journal Article
Beydon M, Seror R, Le Guern V, Chretien P, et al.
📚 10 cit.🎯 RCR 1.34
Transversal18
▼
Transversal18
▼- Baseline characteristics of the TRANSLATE2 cohort: A prospective study on rheumatoid arthritis-associated interstitial lung disease
Joint bone spine · 2026 · Journal Article
Juge PA, Debray MP, Pensec VD, Richez C, et al.
- Macrophage Cell Culture and Characterization by Serum Human AB in Health and Disease
Methods in molecular biology (Clifton, N.J.) · 2026 · Journal Article
Paoletti A, Ly B, Bitoun S, Nocturne G, et al.
- Lessons from organoid engineering for rheumatic disease
Joint bone spine · 2026 · Journal Article
Meudec L, Goudarzi N, Mariette X, Nocturne G
- Sicca induced by immune checkpoint inhibitors
Presse medicale (Paris, France : 1983) · 2025 · Journal Article
Belkhir R, Gosset M, Rousseau A, Bitoun S, et al.
- French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases
Joint bone spine · 2025 · Journal Article
Avouac J, Fogel O, Beydon M, Frémont GM, et al.
🩺 Clinique - Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Annals of the rheumatic diseases · 2025 · Journal Article
Wiley MM, Radziszewski M, Khatri B, Joachims ML, et al.
📚 4 cit. - Cluster analysis identifies three clinical patterns of patients with systemic autoimmune diseases and anti-Ku antibodies
RMD open · 2025 · Journal Article
Robert M, Nguyen Y, Allenbach Y, Sacre K, et al.
- CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
The Lancet. Rheumatology · 2025 · Journal Article
Scherlinger M, Nocturne G, Radic M, Launay D, et al.
📚 28 cit.🎯 RCR 10.18🔬→🩺 Translationnel - Transient migratory osteoporosis of epiphyseal lower limbs during FLOT chemotherapy for gastric cancer
Joint bone spine · 2025 · Letter
Bouchut A, Grimon G, Mariette X, Nocturne G
- Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value
RMD open · 2025 · Journal Article
Cioni P, Chretien P, Goulvestre C, Ballot E, et al.
📚 6 cit.🎯 RCR 2.81 - Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines
Clinical and experimental immunology · 2025 · Journal Article
Naigeon M, Bitoun S, Roulleaux Dugage M, de Oliveira C, et al.
- [(18)F]FDG-PET/CT in Polymyalgia Rheumatica: An Update and Future Aspects
Seminars in nuclear medicine · 2024 · Journal Article
Gheysens O, de Ponfilly MP, Nocturne G, Seror R, et al.
📚 7 cit.🎯 RCR 2.29 - PET/CT in Inflammatory and Auto-immune Disorders: Focus on Several Key Molecular Concepts, FDG, and Radiolabeled Probe Perspectives
Seminars in nuclear medicine · 2024 · Journal Article
Besson FL, Nocturne G, Noël N, Gheysens O, et al.
📚 8 cit.🎯 RCR 2.05 - Liposomal AntagomiR-155-5p Restores Anti-Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis
Arthritis & rheumatology (Hoboken, N.J.) · 2024 · Journal Article
Paoletti A, Ly B, Cailleau C, Gao F, et al.
📚 27 cit.🎯 RCR 5.80 - Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
bioRxiv : the preprint server for biology · 2023 · Journal Article
Wiley MM, Khatri B, Joachims ML, Tessneer KL, et al.
📚 2 cit. - [Inflammatory diseases of the salivary]
La Revue du praticien · 2023 · English Abstract
Nocturne G, Gosset M
- Janus kinase inhibitors alter NK cell phenotypes and inhibit their antitumour capacity
Rheumatology (Oxford, England) · 2023 · Journal Article
Meudec L, Richebé P, Pascaud J, Mariette X, et al.
📚 17 cit.🎯 RCR 2.12🔬→🩺 Translationnel - Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation
Cell death & disease · 2023 · Journal Article
Chirita D, Bronnec P, Magnotti F, Dalmon S, et al.
📚 15 cit.🎯 RCR 1.64
Biothérapies non-anti-TNF2
▼
Biothérapies non-anti-TNF2
▼- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
- Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52
JAK inhibiteurs2
▼
JAK inhibiteurs2
▼- JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events
PloS one · 2025 · Journal Article
Gurevic I, Meudec L, Mariette X, Nocturne G, et al.
📚 1 cit. - JAK Inhibitor Withdrawal Causes a Transient Proinflammatory Cascade: A Potential Mechanism for Major Adverse Cardiac Events
bioRxiv : the preprint server for biology · 2025 · Journal Article
Gurevic I, Meudec L, Mariette X, Nocturne G, et al.
csDMARDs1
▼
csDMARDs1
▼- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
IA en rhumatologie1
▼
IA en rhumatologie1
▼- Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study
The Lancet. Rheumatology · 2025 · Journal Article
Duquesne J, Basseto L, Claye C, Barnes M, et al.
📚 4 cit.
Datasets & protocoles partagés
Uncovering Therapeutic Targets in Sjögren's Disease Using Large-scale Boolean Modelling and Perturbation Analysis
Workflow2026ZenodoThis project is a collaboration between the GenHotel lab and IMVA-HB at Paris-Saclay University. It aims to identify potential therapeutic targets in Sjögren's Disease (SjD) through large-scale computational modeling and
Uncovering Therapeutic Targets in Sjögren's Disease Using Large-scale Boolean Modelling and Perturbation Analysis
Workflow2026ZenodoThis project is a collaboration between the GenHotel lab and IMVA-HB at Paris-Saclay University. It aims to identify potential therapeutic targets in Sjögren's Disease (SjD) through large-scale computational modeling and
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
