Docteur RAPHAELE SEROR
✨ Profil synthétique
IA · 04/05/2026Le Docteur Raphaèle Seror est un rhumatologue à Paris, avec une activité de recherche importante dans le domaine des maladies rhumatismales. Ses travaux portent notamment sur les troubles des glandes salivaires, la polyarthrite rhumatoïde, le lupus érythémateux systémique et la sclérose systémique. Avec un h-index de 67 et plus de 510 publications, il occupe une position académique significative, ayant également dirigé des thèses en santé publique et épidémiologie.
Expertises présumées
- Sjögren
- Polyarthrite rhumatoïde
- Lupus érythémateux systémique
- Sclérose systémique
- Vasculite
- Épidémiologie des maladies rhumatismales
- Biothérapies non-anti-TNF
- Risque cardio-vasculaire chez les patients rhumatismaux
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Direction de thèses
🎓 2 thèses dirigéesEtude des associations entre expositions hormonales féminines, mesures anthropométriques et le risque de polyarthrite rhumatoïde dans la cohorte E3N
2022Doctorant·e : Carine Salliot
Santé publique - épidémiologie🎓 université Paris-SaclayEtude des associations entre tabagisme passif, troubles du transit, alimentation et le risque de polyarthrite rhumatoïde dans la cohorte E3N
2021Doctorant·e : Yann Nguyen
Santé publique - épidémiologie🎓 université Paris-Saclay
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
67
h articles cités ≥ h fois chacun. Un h de 67 = 67 publications avec 67+ citations.
Citations
23 904
Publications
510
i10-index
182
Thématiques principales
- Salivary Gland Disorders and Functions ×216
- Rheumatoid Arthritis Research and Therapies ×107
- Systemic Lupus Erythematosus Research ×97
- Systemic Sclerosis and Related Diseases ×75
- Vasculitis and related conditions ×37
Affiliations FR : Inserm · Université Paris-Saclay · Sorbonne Université
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort
2026ArticleRMD Open
Juvenile-onset mixed connective tissue disease: A multicenter retrospective cohort study
2026ArticleSeminars in Arthritis and Rheumatism
Activity and Damage Indices for Sjögren's Disease
2026ArticleJournal of Clinical Medicine
A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
2026ArticleAnnals of the Rheumatic Diseases
Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren’s disease
2025ArticleAnnals of the Rheumatic Diseases
Impact and risk factors of anti-rituximab antibodies in small-vessel vasculitis: a multicenter retrospective study
2025CongrèsACR Convergence 2025
Unraveling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum
2025CongrèsACR Convergence 2025
Clinical presentation, course, treatment and outcome of juvenile onset versus adult onset mixed connective tissue disease patients: a multicenter retrospective cohort
2025CongrèsACR Convergence 2025
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Localisation
Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.
Lieux de consultation
SERVICE DE SOINS SNCF - PARIS BUDAPEST
16 Rue DE BUDAPEST, 75009 Paris 9e Arrondissement
☎ 0183946237Hospitalier© OpenStreetMapGHU APHP UPS SITE KREMLIN BICETRE APHP
78 Avenue DU GENERAL LECLERC, 94275 Le Kremlin-Bicêtre
☎ 0145212121Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Epidemiology of Sjögren syndrome
Nature reviews. Rheumatology · 2024
📚 123 citations🎯 RCR 28.20Top 0% NIH - 2Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts
The Lancet. Rheumatology · 2024
📚 56 citations🎯 RCR 13.68Top 2% NIH🔓 Open Access - 3Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell-Targeted Therapy in the Trial of Anti-B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS)
Arthritis & rheumatology (Hoboken, N.J.) · 2024
Lire l'abstract Crossref ↓
ObjectiveThis study aimed to identify peripheral and salivary gland (SG) biomarkers of response/resistance to B cell depletion based on the novel concise Composite of Relevant Endpoints for Sjögren Syndrome (cCRESS) and candidate Sjögren Tool for Assessing Response (STAR) composite endpoints.MethodsLongitudinal analysis of peripheral blood and SG biopsies was performed pre‐ and post‐treatment from the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) combining flow cytometry immunophenotyping, serum cytokines, and SG bulk RNA sequencing.ResultsRituximab treatment prevented the worsening of SG inflammation observed in the placebo arm, by inhibiting the accumulation of class‐switched memory B cells within the SG. Furthermore, rituximab significantly down‐regulated genes involved in immune‐cell recruitment, lymphoid organization alongside antigen presentation, and T cell co‐stimulatory pathways. In the peripheral compartment, rituximab down‐regulated immunoglobulins and auto‐antibodies together with pro‐inflammatory cytokines and chemokines. Interestingly, patients classified as responders according to STAR displayed significantly higher baseline levels of C‐X‐C motif chemokine ligand‐13 (CXCL13), interleukin (IL)‐22, IL‐17A, IL‐17F, and tumor necrosis factor‐α (TNF‐α), whereas a longitudinal analysis of serum T cell–related cytokines showed a selective reduction in both STAR and cCRESS responder patients. Conversely, cCRESS response was better associated with biomarkers of SG immunopathology, with cCRESS‐responders showing a significant decrease in SG B cell infiltration and reduced expression of transcriptional gene modules related to T cell costimulation, complement activation, and Fcγ‐receptor engagement. Finally, cCRESS and STAR response were associated with a significant improvement in SG exocrine function linked to transcriptional evidence of SG epithelial and metabolic restoration.ConclusionRituximab modulates both peripheral and SG inflammation, preventing the deterioration of exocrine function with functional and metabolic restoration of the glandular epithelium. Response assessed by newly developed cCRESS and STAR criteria was associated with differential modulation of peripheral and SG biomarkers, emerging as novel tools for patient stratification.image
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Sjögren21
▼
Sjögren21
▼- Evolution and prospects for the definition of clinically useful endpoints in Sjögren disease
Current opinion in immunology · 2026 · Journal Article
Beydon M, Bowman SJ, Seror R
- Patients' perspectives of living with Sjögren disease: A systematic review of qualitative studies from the OMERACT Sjögren disease working group
Seminars in arthritis and rheumatism · 2026 · Systematic Review
Lee AYS, Zembrzuska H, Franke KB, Gordon R, et al.
📚 1 cit. - Activity and Damage Indices for Sjögren's Disease
Journal of clinical medicine · 2026 · Journal Article
Portier E, Beydon M, Bowman SJ, Seror R
- A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
Annals of the rheumatic diseases · 2026 · Journal Article
Beydon M, Dulin M, Ly B, Verstuyft C, et al.
- Primary Sjögren's Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren's Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI)
Annals of the rheumatic diseases · 2025 · Journal Article
Bowman SJ, Seror R, Porcher R, Arends S, et al.
📚 10 cit.🎯 RCR 4.23 - Distinct Pathophysiologic Pathways Support Stratification of Sjögren's Disease Based on Symptoms, Clinical, and Routine Biological Data
Arthritis & rheumatology (Hoboken, N.J.) · 2025 · Journal Article
Nguyen Y, Beydon M, Gottenberg JE, Morel J, et al.
📚 12 cit.🎯 RCR 4.86 - Impact of Sjögren's disease on quality of sexual life using the Qualisex score
RMD open · 2025 · Journal Article
Kachaner A, Seror R, Le Guern V, Dieudé P, et al.
- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
- Real-World Assessment of Systemic Disease Activity in Seropositive and Seronegative Patients with Sjögren's Disease and Association with Patient-Reported Outcomes
Rheumatology and therapy · 2025 · Journal Article
Gottenberg JE, Seror R, Massey N, Hughes M, et al.
- Association between anti-SSA/SSB antibody profiles and patient-reported outcomes in primary Sjögren's disease
Rheumatology (Oxford, England) · 2025 · Journal Article
Robert M, Nguyen Y, Belkhir R, Desmoulins F, et al.
- A Systematic Review of Clinical Trial Designs and Outcome Measures in Sjögren Disease Randomized Controlled Trials
The Journal of rheumatology · 2025 · Journal Article
Beydon M, Nguyen Y, Gordon R, Foulquier N, et al.
📚 5 cit.🎯 RCR 2.10 - Conception in women with primary Sjögren's disease
RMD open · 2024 · Letter
Martin de Frémont G, Le Guern V, Seror R
📚 1 cit. - Development of a web-based ecological momentary assessment tool to measure day-to-day variability of the symptoms in patients with Sjögren's disease
RMD open · 2024 · Journal Article
Georgel L, Benyoussef AA, Berrouiguet S, Guellec D, et al.
📚 2 cit.🩺 Clinique - Treatment modalities of marginal zone lymphoma and overall survival, haematological response, and underlying Sjögren's disease activity: a multicentre, retrospective, observational study
The Lancet. Rheumatology · 2024 · Journal Article
Rocca J, Beydon M, Le Guern V, Hachulla E, et al.
📚 10 cit.🎯 RCR 2.20🩺 Clinique - Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell-Targeted Therapy in the Trial of Anti-B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS)
Arthritis & rheumatology (Hoboken, N.J.) · 2024 · Journal Article
Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, et al.
📚 19 cit.🎯 RCR 4.43🩺 Clinique - Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts
The Lancet. Rheumatology · 2024 · Journal Article
Nguyen Y, Nocturne G, Henry J, Ng WF, et al.
📚 56 cit.🎯 RCR 13.68🔬→🩺 Translationnel - Identification of outcome domains in primary Sjögren's disease: A scoping review by the OMERACT Sjögren disease working group
Seminars in arthritis and rheumatism · 2024 · Journal Article
Nguyen Y, Beydon M, Foulquier N, Gordon R, et al.
📚 6 cit.🎯 RCR 1.72 - The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation
Seminars in arthritis and rheumatism · 2024 · Journal Article
Gordon RA, Nguyen Y, Foulquier N, Beydon M, et al.
📚 7 cit.🎯 RCR 2.18 - Epidemiology of Sjögren syndrome
Nature reviews. Rheumatology · 2024 · Journal Article
Beydon M, McCoy S, Nguyen Y, Sumida T, et al.
📚 123 cit.🎯 RCR 28.20🔬→🩺 Translationnel - Characterisation of airway disease associated with Sjögren disease
RMD open · 2024 · Journal Article
Meudec L, Debray MP, Beurnier A, Marques C, et al.
📚 3 cit.🎯 RCR 1.04 - Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52
Transversal15
▼
Transversal15
▼- Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort
RMD open · 2026 · Journal Article
Hornez M, Molto A, Leroy M, Banneville B, et al.
- Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort
RMD open · 2026 · Journal Article
Dusser P, Nguyen Y, Perrin C, Frénoy P, et al.
- Evaluation of pregnancy outcomes in patients with spondyloarthritis compared to the general population: results from a French national prospective and matched study
Annals of the rheumatic diseases · 2026 · Journal Article
Hamroun S, de Frémont GM, Costedoat-Chalumeau N, Couderc M, et al.
- Cluster analysis identifies three clinical patterns of patients with systemic autoimmune diseases and anti-Ku antibodies
RMD open · 2025 · Journal Article
Robert M, Nguyen Y, Allenbach Y, Sacre K, et al.
- Use of immunosuppressants and biologics in giant cell arteritis: Recommendations of the French Study Group for Large Vessel Vasculitis (GEFA)
La Revue de medecine interne · 2025 · Journal Article
de Boysson H, Devauchelle-Pensec V, Agard C, André M, et al.
📚 2 cit.🩺 Clinique - French protocol for the diagnosis and management of giant cell arteritis
La Revue de medecine interne · 2025 · Journal Article
de Boysson H, Devauchelle-Pensec V, Agard C, André M, et al.
📚 12 cit.🎯 RCR 4.97🔬→🩺 Translationnel - Cancer risk of Janus kinase inhibitors and biological disease-modifying antirheumatic drugs among older Americans with rheumatoid arthritis
Rheumatology (Oxford, England) · 2025 · Journal Article
Ahmed S, Pfeiffer RM, Jackson SS, Song M, et al.
📚 3 cit. - Association between antibiotic use and the onset of giant cell arteritis and polymyalgia rheumatica: A nested case-control study from E3N-European Prospective Investigation into Cancer and Nutrition
Journal of internal medicine · 2025 · Journal Article
Pacoureau L, Barde F, Gelot A, Elbaz A, et al.
📚 1 cit. - Molecular profiling and risk stratification in solitary bone plasmacytoma
Leukemia · 2025 · Journal Article
Burroni B, Harel S, Seror R, Ascione S, et al.
- French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases
Joint bone spine · 2025 · Journal Article
Avouac J, Fogel O, Beydon M, Frémont GM, et al.
🩺 Clinique - 2024 update of the recommendations of the French Society of Rheumatology for the diagnosis and management of patients with rheumatoid arthritis
Joint bone spine · 2024 · Journal Article
Fautrel B, Kedra J, Rempenault C, Juge PA, et al.
📚 10 cit.🎯 RCR 2.84🔬→🩺 Translationnel - Recommendations of the French Society of Rheumatology for the management in current practice of patients with polymyalgia rheumatica
Joint bone spine · 2024 · Journal Article
Wendling D, Al Tabaa O, Chevet B, Fakih O, et al.
📚 12 cit.🎯 RCR 3.28🩺 Clinique - High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture
Bone reports · 2024 · Journal Article
Chevalier K, Hamroun S, Bitoun S, Henry J, et al.
📚 1 cit. - [(18)F]FDG-PET/CT in Polymyalgia Rheumatica: An Update and Future Aspects
Seminars in nuclear medicine · 2024 · Journal Article
Gheysens O, de Ponfilly MP, Nocturne G, Seror R, et al.
📚 7 cit.🎯 RCR 2.29 - 2023 French recommendations for diagnosing and managing prepatellar and olecranon septic bursitis
Joint bone spine · 2024 · Review
Darrieutort-Laffite C, Coiffier G, Aïm F, Banal F, et al.
Connectivite mixte4
▼
Connectivite mixte4
▼- Juvenile-onset mixed connective tissue disease: A multicenter retrospective cohort study
Seminars in arthritis and rheumatism · 2026 · Journal Article
Chevalier K, Bader-Meunier B, Kone-Paut I, Thoreau B, et al.
- Treatment of mixed connective tissue disease: A multicenter retrospective study
Journal of autoimmunity · 2025 · Journal Article
Chevalier K, Thoreau B, Michel M, Godeau B, et al.
📚 5 cit.🎯 RCR 2.18🩺 Clinique - Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum
RMD open · 2025 · Journal Article
Chevalier K, Thoreau B, Michel M, Godeau B, et al.
🩺 Clinique - Clinical presentation, course, and prognosis of patients with mixed connective tissue disease: A multicenter retrospective cohort
Journal of internal medicine · 2024 · Journal Article
Chevalier K, Thoreau B, Michel M, Godeau B, et al.
📚 12 cit.🎯 RCR 3.42🩺 Clinique
Épidémiologie & registres4
▼
Épidémiologie & registres4
▼- Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study
RMD open · 2025 · Journal Article
Triboulet F, Juge PA, Truchetet ME, Pham T, et al.
📚 6 cit.🎯 RCR 2.47🩺 Clinique - Early-life animal and farming exposures and the risk of rheumatoid arthritis: findings from the E3N French cohort study
RMD open · 2025 · Journal Article
Dusser P, Nguyen Y, Perrin C, Frénoy P, et al.
🩺 Clinique - Prophylaxis with tixagevimab/cilgavimab is associated with lower COVID-19 incidence and severity in patients with autoimmune diseases
Rheumatology (Oxford, England) · 2024 · Journal Article
Thomas M, Masson M, Bitoun S, Hamroun S, et al.
📚 5 cit.🩺 Clinique - Evolution of monoclonal gammopathy of undetermined significance in patients treated with JAK inhibitors for rheumatic diseases: data from the MAJIK-SFR registry
Rheumatology (Oxford, England) · 2024 · Journal Article
Faganello D, Bertrand A, Meunier P, Avouac J, et al.
📚 2 cit.
Biothérapies non-anti-TNF3
▼
Biothérapies non-anti-TNF3
▼- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
- Can efficacy and safety data from clinical trials of rituximab in RA be extrapolated? Insights from 1984 patients from the AIR-PR Registry
Rheumatology (Oxford, England) · 2024 · Journal Article
Nguyen Y, Mariette X, Gottenberg JE, Iudici M, et al.
📚 2 cit. - Obinutuzumab in patients with Sjogren's disease immunised against rituximab
Annals of the rheumatic diseases · 2024 · Letter
Pezot M, Nocturne G, Belkhir R, Henry J, et al.
📚 8 cit.🎯 RCR 1.52
Risque cardio-vasculaire3
▼
Risque cardio-vasculaire3
▼- Cardiovascular risk among Giant cells arteritis patients
European journal of preventive cardiology · 2026 · Journal Article
Guedon AF, Espitia O, Beydon M, Ghrenassia E, et al.
📚 2 cit. - Low-Dose Aspirin for Cardiovascular Disease Primary Prevention in Patients With Giant Cell Arteritis
JAMA network open · 2026 · Journal Article
Beydon M, Hajage D, Guédon AF, Carrat F, et al.
- Association between cardiovascular risk factors and the occurrence of giant cell arteritis: a systematic review and meta-analysis
Rheumatology (Oxford, England) · 2025 · Journal Article
Barde F, Pacoureau L, Elbaz A, Seror R, et al.
📚 2 cit.
Anti-TNF1
▼
Anti-TNF1
▼- Do SMS/e-mail reminders increase influenza vaccination of rheumatoid arthritis patients under anti-TNF: a nested randomized controlled trial in the ART e-cohort
Rheumatology (Oxford, England) · 2025 · Journal Article
Nguyen Y, Baron G, Hamamouche N, Belkhir R, et al.
📚 1 cit.🩺 Clinique
csDMARDs1
▼
csDMARDs1
▼- Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease
Annals of the rheumatic diseases · 2025 · Journal Article
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, et al.
Ostéoporose1
▼
Ostéoporose1
▼- Complete remission after a single bisphosphonate infusion in isolated bone Langerhans cell histiocytosis lesion: a case report and a narrative review of the literature
JBMR plus · 2024 · Case Reports
Kachaner A, Seror R, Aubart FC, Henry J, et al.
Datasets & protocoles partagés
Additional file 1 of Management of dental care of patients on immunosuppressive drugs for chronic immune-related inflammatory diseases: a survey of French dentists’ practices
Audiovisual2023figshareAdditional file 1: Supplemental Figure 1. Training of general and specialist dentists in France.
Management of dental care of patients on immunosuppressive drugs for chronic immune-related inflammatory diseases: a survey of French dentists’ practices
Collection2023figshareAbstract Objectives The aim of the study was to provide an overview of the practices of French general dentists (GDs) and specialists (SDs) concerning the management of patients with inflammatory bowel diseases (IBDs), r
Management of dental care of patients on immunosuppressive drugs for chronic immune-related inflammatory diseases: a survey of French dentists’ practices
Collection2023figshareAbstract Objectives The aim of the study was to provide an overview of the practices of French general dentists (GDs) and specialists (SDs) concerning the management of patients with inflammatory bowel diseases (IBDs), r
Additional file 1 of Management of dental care of patients on immunosuppressive drugs for chronic immune-related inflammatory diseases: a survey of French dentists’ practices
Audiovisual2023figshareAdditional file 1: Supplemental Figure 1. Training of general and specialist dentists in France.
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
