M MICHEL NGUYEN

Pourquoi vous devez consulter ce praticien

5 raisons identifiées

Plateau technique de référence

Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes

Auteur de référence en rhumatologie

50 articles scientifiques publiés — un praticien à la pointe de la recherche

Expérience confirmée

25 ans d'exercice en rhumatologie — recul clinique solide

Disponibilité géographique

5 lieux d'exercice — choisissez celui qui vous arrange

Délais de RDV courts dans la région

134 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CRETEIL CEDEX (94)MixteRPPS 10001492270

Expérience confirmée

25ans d'exercice (thèse 2001)

📊 Reconnaissance scientifique : 38/100📝 209 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Profil synthétique

IA · 20/05/2026

Le Dr Michel Nguyen est un rhumatologue avec une expérience significative dans la recherche, comme en témoignent ses 209 publications et son h-index de 38. Ses travaux de recherche couvrent divers domaines, notamment le traitement et la gestion du mélanome cutané, les traitements de l'acné et du rosacée, ainsi que l'immunothérapie et les biomarqueurs du cancer. Ses publications PubMed révèlent une expertise dans les domaines de la revue générale, des anti-TNF, des biomarqueurs et des biothérapies non anti-TNF.

Expertises présumées

Rhumatologie
Mélanome cutané
Immunothérapie
Biomarqueurs
Thérapies anti-TNF
Biothérapies non anti-TNF
Santé mentale et fatigue

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice

Nature biomedical engineering · 2024

📚 50 citations🎯 RCR 9.35Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractButyrate—a metabolite produced by commensal bacteria—has been extensively studied for its immunomodulatory effects on immune cells, including regulatory T cells, macrophages and dendritic cells. However, the development of butyrate as a drug has been hindered by butyrate’s poor oral bioavailability, owing to its rapid metabolism in the gut, its low potency (hence, necessitating high dosing), and its foul smell and taste. Here we report that the oral bioavailability of butyrate can be increased by esterifying it to serine, an amino acid transporter that aids the escape of the resulting odourless and tasteless prodrug (O-butyryl-l-serine, which we named SerBut) from the gut, enhancing its systemic uptake. In mice with collagen-antibody-induced arthritis (a model of rheumatoid arthritis) and with experimental autoimmune encephalomyelitis (a model of multiple sclerosis), we show that SerBut substantially ameliorated disease severity, modulated key immune cell populations systemically and in disease-associated tissues, and reduced inflammatory responses without compromising the global immune response to vaccination. SerBut may become a promising therapeutic for autoimmune and inflammatory diseases.

Translocating gut pathobiont Enterococcus gallinarum induces T(H)17 and IgG3 anti-RNA-directed autoimmunity in mouse and human

Science translational medicine · 2025

📚 22 citations🎯 RCR 8.57

Lire l'abstract Crossref ↓

Chronic autoimmune diseases often lead to long-term sequelae and require lifelong immunosuppression because of an incomplete understanding of the triggers and drivers in genetically predisposed patients. Gut bacteria that escape the gut barrier, known as translocating gut pathobionts, have been implicated as instigators and perpetuators of extraintestinal autoimmune diseases in mice. The gut microbial contributions to autoimmunity in humans remain largely unclear, including whether specific pathological human adaptive immune responses are triggered by such pathobionts. Here, we show that the translocating pathobiont Enterococcus gallinarum can induce both human and mouse interferon-γ + T helper 17 (T H 17) differentiation and immunoglobulin G3 (IgG3) subclass switch of anti– E. gallinarum RNA antibodies, which correlated with anti-human RNA autoantibody responses in patients with systemic lupus erythematosus (SLE) and autoimmune hepatitis, two extraintestinal autoimmune diseases. E. gallinarum RNA, but not human RNA, triggered Toll-like receptor 8 (TLR8), and TLR8-mediated human monocyte activation promoted human T H 17 induction by E. gallinarum . Translocation of the pathobiont triggered increased anti-RNA autoantibody titers that correlated with renal autoimmune pathophysiology in murine gnotobiotic lupus models and with disease activity in patients with SLE. These studies elucidate cellular mechanisms of how a translocating gut pathobiont induces systemic human T cell– and B cell–dependent autoimmune responses and provide a framework for developing host- and microbiota-derived biomarkers and targeted therapies in autoimmune diseases.

High Tyrosol and Hydroxytyrosol Intake Reduces Arterial Inflammation and Atherosclerotic Lesion Microcalcification in Healthy Older Populations

Antioxidants (Basel, Switzerland) · 2024

📚 14 citations🎯 RCR 4.49Top 9% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Aging is an important risk factor for cardiovascular diseases and convincing data have shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to cardiovascular risk. The present study aimed to use 18F-FDG/18F-NaF-PET/CT imaging to, respectively, gauge arterial inflammation and microcalcification in a healthy elderly population and to assess the potential benefits of a tyrosol- and hydroxytyrosol-rich diet on these two markers of atherosclerotic plaque fragility. Eleven healthy participants (mean age 75 ± 5.67 years) were supplemented for 6 months with high polyphenol-rich extra virgin olive oil (HP-EVOO), extra virgin olive oil (EVOO), or refined olive oil (ROO). The participants underwent PET/CT imaging with 18F-FDG and 18F-NaF radiotracers at baseline and after 6 months. 18F-FDG and 18F-NaF uptakes were quantified using standardized uptake values (SUV) and were categorized based on artery calcification and olive oil type. A total of 324 slices of the aortas of the imaged participants were analyzed for arterial inflammation and 327 slices were analyzed for microcalcification. 18F-FDG uptake was significantly higher in the non-calcified segments than in the calcified segments (SUVmax = 2.70 ± 0.62 and SUVmax = 2.54 ± 0.44, respectively, p < 0.042). Conversely, the non-calcified segments displayed significantly lower 18F-NaF uptake than the calcified segments (SUVmax = 1.90 ± 0.37 and 2.09 ± 0.24, respectively, p < 0.0001). The 6-month supplementation with HP-EVOO induced a significant reduction in 18F-FDG uptake in both the non-calcified (2.93 ± 0.23 to 2.75 ± 0.38, p < 0.004) and calcified segments of the aortas (2.25 ± 0.29 to 2.15 ± 0.19, p < 0.02). 18F-NaF uptake was also significantly lower in patients supplemented with HP-EVOO (SUVmax = 1.98 ± 0.33 at baseline compared to 1.85 ± 0.28, after the 6-month supplementation, p < 0.004), whereas no significant effect was observed with EVOO. Conversely, participants supplemented with ROO displayed a significant increase in 18F-NaF uptake (SUVmax = 1.78 ± 0.34 to 1.95 ± 0.34, p < 0.0001). The present study confirmed that a phenolic-compound-rich diet reduces both arterial inflammation and atherosclerotic lesion microcalcification and demonstrated that 18F-FDG/18F-NaF-PET/CT imaging is a valuable approach for assessing age-related arterial damage.

Cookies & analyse de trafic

M MICHEL NGUYEN

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Activité de recherche & publications

Publications académiques en France

Lieux de consultation(4)

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal32

Revue générale3

Anti-TNF2

Case report / série2

Santé mentale / fatigue2

Biomarqueurs / Auto-Ac1

Biothérapies non-anti-TNF1

Corticothérapie1

Essai clinique1

Gériatrie1

Goutte1

IA en rhumatologie1

Lupus1

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

Vascularites1

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