📇 Rhumatologue · VILLEBON SUR YVETTE · (91) · Libéral

M Hung-Viet NGUYEN

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Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
73.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 VILLEBON SUR YVETTE (91)LibéralRPPS 10000887751

📊 Reconnaissance scientifique : 24/100📝 146 articles publiés🇫🇷 Publications académiques françaises (3)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity

Science translational medicine · 2025

📚 10 citations🎯 RCR 3.77🔓 Open Access

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Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited understanding of the cellular basis of inflammation in the target tissue of the disease, the synovial membrane. Here, we analyzed biopsies from the inflamed joints of treatment-naïve children with JIA, early in the course of their disease, using single-cell RNA sequencing, multiplexed immunofluorescence, and spatial transcriptomics to establish a cellular atlas of the JIA synovium. We identified distinct spatial tissue niches, composed of specific stromal and immune cell populations. In addition, we localized genes linked to arthritis severity and disease risk to effector cell populations, including tissue resident SPP1 + macrophages and fibrin-associated myeloid cells. Combined analyses of synovial fluid and peripheral blood from matched individuals revealed differences in cellular composition, signaling pathways, and transcriptional programs across these distinct anatomical compartments. Furthermore, our analysis revealed several pathogenic cell populations that are shared with adult-onset inflammatory arthritis, as well as age-associated differences in tissue vascularity, prominence of innate immunity, and enrichment of TGF-β–responsive stromal subsets that up-regulate expression of disease risk–associated genes. Overall, our findings demonstrate the need for age-specific analyses of synovial tissue pathology to guide targeted treatment strategies in JIA.

Artificial intelligence system for predicting areal bone mineral density from plain X-rays

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

Family-based whole-exome sequencing implicates a variant in lysyl oxidase like 4 in atypical femur fractures

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

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Abstract Atypical femur fractures (AFFs) are rare adverse events associated with bisphosphonate use, having unclear pathophysiology. AFFs also cluster in families and have occurred in patients with monogenetic bone diseases sometimes without bisphosphonate use, suggesting an underlying genetic susceptibility. Our aim was to identify a genetic cause for AFF in a Caucasian family with 7 members affected by osteoporosis, including 3 siblings with bisphosphonate-associated AFFs. Using whole-exome sequencing, we identified a rare pathogenic variant c.G1063A (p.Gly355Ser) in lysyl oxidase like 4 (LOXL4) among 64 heterozygous rare, protein-altering variants shared by the 3 siblings with AFFs. The same variant was also found in a fourth sibling with a low-trauma femur fracture above the knee, not fulfilling all the ASBMR criteria of AFF and in 1 of 73 unrelated European AFF patients. LOXL4 is involved in collagen cross-linking and may be relevant for microcrack formation and bone repair mechanisms. Preliminary functional analysis showed that skin fibroblast-derived osteoblasts from the unrelated patient with the LOXL4 variant expressed less collagen type I and elastin, while osteogenic differentiation and mineralization were enhanced compared with 2 controls. In conclusion, this LOXL4 variant may underlie AFF susceptibility possibly due to abnormal collagen metabolism, leading to increased formation of microdamage or compromised healing of microcracks in the femur.

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M Hung-Viet NGUYEN

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (26) — classées par pathologie

Transversal12

IA en rhumatologie2

Revue générale2

Santé mentale / fatigue2

Arthrite juvénile1

Case report / série1

Épidémiologie & registres1

Essai clinique1

Goutte1

Lupus1

Microbiote1

Pédiatrie1

Qualité de vie / PROMs1

Revue / méta-analyse1

Vascularites1

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