📇 Rhumatologue ·

M DOMINIQUE NGUYEN

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2 raisons identifiées

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue

Rhumatologue

RPPS 10001322337

4 publications sur 5 ans

📊 Reconnaissance scientifique : 12/100📝 29 articles publiés🇫🇷 Publications académiques françaises (2)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Nature medicine · 2023

📚 106 citations🎯 RCR 9.00Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (<380 AU ml−1). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies.

Apremilast monotherapy in DMARD-naive psoriatic arthritis patients: results of the randomized, placebo-controlled PALACE 4 trial

Rheumatology (Oxford, England) · 2018

📚 79 citations🎯 RCR 3.76Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE)

Annals of the rheumatic diseases · 2018

📚 62 citations🎯 RCR 3.05Top 16% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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M DOMINIQUE NGUYEN

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Activité de recherche & publications

Publications académiques en France

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Articles de presse (1)

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal31

Lupus6

Anti-TNF3

Essai clinique2

IA en rhumatologie2

Case report / série1

Épidémiologie & registres1

Génétique1

Pharmacovigilance1

Revue générale1

Sclérodermie1

Tendinopathies & SCC1

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