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Auteur de référence en rhumatologie
38 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
73.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR YEN THI NGUYEN-ARNAUD
POLYCLINIQUE GRANGER 14 AVENUE GRANGER, 91210 DRAVEIL
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Blood advances · 2026
Abstract Central nervous system (CNS) status in pediatric acute lymphoblastic leukemia (ALL) is a key prognostic factor that makes precise detection critical. Flow cytometry (FCM) offers a higher detection rate than conventional cytomorphology (CC); however, results are considered negative with <10 FCM events, limiting its sensitivity. This study analyzed the cerebrospinal fluid from 173 pediatric patients with ALL using both CC and FCM, characterizing immunoglobulin heavy chain rearrangement clonotypes using next-generation sequencing (NGS). The sensitivities of CC and FCM were similar (P = .824) when the standard FCM positivity threshold was used. Receiver operating characteristic analysis based on NGS showed ≥3 events as the optimal FCM positivity cutoff, significantly improving sensitivity over CC (P = .005). Among patients treated according to the Taiwan Pediatric Oncology Group 2013 ALL protocol, FCM positivity correlated with lower event-free survival (EFS) and higher cumulative incidence of CNS relapse (CIRCNS). Patients with hyperdiploidy who were CC-negative/FCM-positive had worse EFS and CIRCNS when receiving less intensive CNS-directed treatments. The 3-event cutoff for FCM positivity enhances the detection of CNS involvement in pediatric ALL and, when combined with CC, identifies patients at a higher risk of CNS relapse, highlighting the potential need for treatment intensification.
The Journal of clinical endocrinology and metabolism · 2026
Abstract Context The hallmark condition of Prader-Willi syndrome, a rare, genetic neurobehavioral/metabolic disorder, is life-threatening hyperphagia. Objective We assessed the efficacy and safety of diazoxide choline extended-release (DCCR) tablets for the treatment of hyperphagia in adults and children four years of age and older with Prader-Willi syndrome. Methods We conducted a 16-week, randomized withdrawal study in children and adults with Prader-Willi syndrome and hyperphagia. Participants who previously completed randomized (13-week DCCR or placebo) and open-label (2.5-4.5 years DCCR) studies were randomized 1:1 to receive once-daily DCCR or placebo. The primary endpoint was Hyperphagia Questionnaire for Clinical Trials (HQ-CT) total score change from baseline to 16 weeks. Secondary endpoints included Clinical Global Impression of Severity (CGI-S) and Improvement (CGI-I); exploratory endpoints included weight and body mass index (BMI) z-score. Results Seventy-seven participants were randomized (DCCR:38; placebo:39). Statistically significant increases in HQ-CT from baseline to week 16 were observed with placebo vs DCCR [least square (LS) mean (standard error) change 7.6 (1.09)] with placebo and 2.6 (1.12) with DCCR; P = .0022. CGI scores favored DCCR but were not significantly changed. Consistent with the hyperphagia response, the placebo cohort gained more weight and increased their BMI z-score more than the DCCR cohort [LS mean weight difference (95% confidence interval) −1.6 kg (−3.1, −0.1)]; LS mean z-score difference was −0.09 (−0.17, −0.01). Adverse events were similar with both treatments, with no serious adverse events in the DCCR arm. Conclusion Continued DCCR treatment was superior to placebo for hyperphagia. DCCR appears to offer meaningful therapeutic benefits for people with Prader-Willi syndrome.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · Journal Article
Yen YH, Liu YW
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2026 · Journal Article
Yen YH, Liu YW, Hung CH, Chen CH, et al.
Diabetes research and clinical practice · 2026 · Journal Article
Yen FS, Wei JC, Hung YM, Liu JS, et al.
Clinical orthopaedics and related research · 2026 · Journal Article
Yang E, Lin HC, Shimomura S, Lee J, et al.
Surgical endoscopy · 2026 · Journal Article
Yu CH, Tai WC, Hsu WH, Chen MY, et al.
Drug delivery and translational research · 2026 · Journal Article
Yu LY, Shueng PW, Wang YH, Yen YW, et al.
Matrix biology : journal of the International Society for Matrix Biology · 2026 · Journal Article
Tamburro MK, Carlson JA, Yen WK, Weiss SN, et al.
Familial cancer · 2026 · Journal Article
Patel SG, Loomans-Kropp HA, Foda ZH, Katona BW, et al.
Frontiers in medicine · 2026 · Journal Article
Yen C, Yen T
ACR open rheumatology · 2026 · Journal Article
Yen EY, Park EJ, Singh RR
Neurosurgical focus · 2026 · Comparative Study
Kharas N, Robayo A, Wang E, Turner JD, et al.
Neurosurgical focus · 2026 · Journal Article
Alan N, Kumar J, Dada A, Elguindy M, et al.
Neurosurgical focus · 2026 · Comparative Study
Harbert AL, Gelinne A, Mummaneni VP, Turner JD, et al.
Neurosurgical focus · 2026 · Journal Article
Bhowmick DA, Succop B, Bisson EF, Bydon M, et al.
Neurosurgical focus · 2026 · Journal Article
Linzey JR, Harbert A, Gelinne A, Upadhyaya CD, et al.
Neurosurgical focus · 2026 · Journal Article
Dada A, Buckley N, Saggi S, DiGiorgio A, et al.
Neurosurgical focus · 2026 · Journal Article
Khan FA, Chabot PJ, Bisson EF, Bydon M, et al.
Neurosurgical focus · 2026 · Journal Article
Zeitouni D, Matache IM, Tahir I, Kentzinsky HV, et al.
Neurosurgical focus · 2026 · Journal Article
Yee TJ, Ambati VS, Kumar J, Atluri S, et al.
Neurosurgical focus · 2026 · Journal Article
Zeitouni D, Tahir I, Matache IM, Kentzinsky HV, et al.
Neurosurgical focus · 2026 · Journal Article
White MD, Tahir I, Delawan M, Asher AL, et al.
Neurosurgical focus · 2026 · Journal Article
Berlin C, Tahir I, Cassimatis N, Delawan M, et al.
Patient education and counseling · 2026 · Journal Article
Martinez-Pereira A, Badola S, Mistler LA, Yen R, et al.
Patient education and counseling · 2026 · Journal Article
Yen RW, Singh A, Chen D, Barr PJ, et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026 · Journal Article
Yen CC, Wu IC, Yu CC, Chen MH, et al.
Diabetology & metabolic syndrome · 2026 · Journal Article
Tan VM, Anh KTL, Hien LTD, Trang VTT, et al.
Neurosurgical focus · 2026 · Journal Article
Englander Z, Ambati VS, Yang E, Mummaneni PV, et al.
Neurosurgical focus · 2026 · Journal Article
Park C, Fox BQ, DiGiorgio AM, Bisson EF, et al.
Neurosurgical focus · 2026 · Journal Article
Berlin C, Delawan M, Matache IM, Kabangu JK, et al.
Archives of public health = Archives belges de sante publique · 2026 · Journal Article
Wang CC, Lin YK, Lai YJ, Chen YY, et al.
The Journal of asthma : official journal of the Association for the Care of Asthma · 2026 · Journal Article
Hung CT, Yen TA, Huang HY, Wu CH
Journal of assisted reproduction and genetics · 2026 · Journal Article
Yen TH, Hung CH, Chen CW, Lai KJ, et al.
Computers, informatics, nursing : CIN · 2026 · Journal Article
Mugoya R, Thate J, Fan H, Rossetti SC, et al.
The Journal of clinical endocrinology and metabolism · 2026 · Journal Article
Miller JL, Bridges N, Felner EI, Salehi P, et al.
Journal of bone oncology · 2026 · Journal Article
Lin CW, Wang HY, Yu CE, Yen HK, et al.
Blood advances · 2026 · Journal Article
Chou SW, Su YH, Lu MY, Chang HH, et al.
Diabetology & metabolic syndrome · 2026 · Journal Article
Tan VM, Anh KTL, Hien LTD, Trang VTT, et al.
Neurosurgical focus · 2026 · Journal Article
Alan N, Dada A, Kumar J, Le VP, et al.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026 · Journal Article
Hung CH, Yen FS, Huang JY, Cheng-Chung Wei J