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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
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Expert review of vaccines · 2025
The Lancet. Microbe · 2025
Frontiers in neurology · 2025
IntroductionGeneralized myasthenia gravis (gMG) is a rare, chronic, autoimmune disorder with a substantial disease burden. Oral glucocorticoids (GCs) are one of the common early-line treatments used globally, but there are growing concerns regarding risks associated with GC adverse effects, which can have serious medical consequences. In Japan, an important gMG treatment goal is minimal disease manifestation with a low target GC dose (≤5 mg/day) to minimize GC exposure. This study aimed to assess gMG treatment patterns in Japan, with a focus on GC exposure and incident comorbidities associated with long-term GC use.MethodsThis was a retrospective, observational database study of patient data from the Medical Data Vision (MDV) database (2008–2022) in Japan. Adults (aged ≥18 years) with ≥2 gMG diagnosis records were considered. First gMG diagnosis (ocular MG excluded) between 2018 and 2021 was considered the index date. All available follow-up was considered if the patient had ≥1 activity in the database annually after the index date.ResultsOf 9,687 patients with gMG (mean age: 65 years; 56% female; follow-up period: 3.2 years) included in the study, 3,696 (38.2%) were newly diagnosed (2018 onwards) and 5,991 (61.8%) were previously diagnosed (before 2018). Acetylcholinesterase inhibitor (AChEi) and GC monotherapy were the most common initial therapies after index, and most patients were treated with combinations of AChEi, GC, and/or nonsteroidal immunosuppressive therapies (NSISTs). The average daily GC dose was 8.5 mg/day (newly diagnosed: 10.6 mg/day; previously diagnosed: 7.5 mg/day). The target daily dose of 5 mg/day was exceeded by 70% of GC-treated patients, and 26% exceeded 10 mg/day (newly diagnosed: 35%; previously diagnosed: 21%). Compared to patients with no GC exposure, GC use was dose-dependently associated with osteoporosis, thrombosis, diabetes, and hyperlipidemia/hypercholesterolemia, even at GC doses ≤5 mg/day.ConclusionMost patients were treated with AChEi, GC, or NSIST monotherapy or combination therapies and received GCs exceeding 5 mg/day, which was associated with developing several GC-associated comorbidities in a dose-dependent manner. To achieve treatment goals, patients with gMG may benefit from additional treatment approaches to reduce GC usage.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Global public health · 2026 · Journal Article
Nguyen A
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ImmunoHorizons · 2026 · Journal Article
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Cytokine · 2026 · Journal Article
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World journal of microbiology & biotechnology · 2025 · Journal Article
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Archives of orthopaedic and trauma surgery · 2025 · Journal Article
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Frontiers in neurology · 2025 · Journal Article
Teranishi H, Tsuda K, Harada D, Yachendra C, et al.
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European journal of internal medicine · 2025 · Letter
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Molecules (Basel, Switzerland) · 2025 · Journal Article
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JMIR human factors · 2025 · Journal Article
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Frontiers in pediatrics · 2025 · Case Reports
Le HT, Nguyen DTA, Vo TLD, Nguyen LTT, et al.
Journal of global health · 2025 · Journal Article
Shaaban FL, Garba MA, Nguyen A, Pecenka C, et al.
Alzheimer's & dementia (Amsterdam, Netherlands) · 2026 · Journal Article
Karamacoska D, Yu K, Liang J, Phung M, et al.
Expert review of vaccines · 2025 · Journal Article
Ho NT, Smolenov I, Thi Le Tran L, Nguyen VT, et al.
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JAAD case reports · 2026 · Case Reports
Rauwerdink DJW, Melchers RC, Quint KD, Nguyen AL, et al.
JBJS case connector · 2026 · Journal Article
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Frontiers in pediatrics · 2025 · Case Reports
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JAMA network open · 2026 · Journal Article
Pevnick JM, Kennelty K, Nguyen AT, Amer K, et al.
EClinicalMedicine · 2025 · Journal Article
Grummitt L, O'Dean S, Birrell L, Bailey S, et al.
Expert review of vaccines · 2025 · Journal Article
Ho NT, Smolenov I, Thi Le Tran L, Nguyen VT, et al.
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Ho NT, Smolenov I, Thi Le Tran L, Nguyen VT, et al.
Contraception · 2025 · Journal Article
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Investigative and clinical urology · 2025 · Letter
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Grummitt L, O'Dean S, Birrell L, Bailey S, et al.
Arts & health · 2025 · Journal Article
Birrell L, Barrett E, Oliver E, Nguyen A, et al.
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Oyeleye-Adegbite OC, Olu-Lawal OD, Busari RA, Osaigbovo JO, et al.
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Rave N, Sharma AK, Chapagain RH, Nguyen A, et al.
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Oyeleye-Adegbite OC, Olu-Lawal OD, Busari RA, Osaigbovo JO, et al.
Journal of global health · 2025 · Journal Article
Shaaban FL, Garba MA, Nguyen A, Pecenka C, et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2026 · Journal Article
Tunon-Robinson I, Zhang R, Nguyen AK
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025 · Journal Article
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Scientific reports · 2025 · Journal Article
An NN, Tung DQ, Van Tue L, Son NT, et al.
Journal of autoimmunity · 2025 · Journal Article
Sendo S, Vela AJ, Ro M, Thiruppathy D, et al.
Contraception · 2025 · Journal Article
Nguyen AT, Nandi P, Roe AH, Pecker LH, et al.
Journal of wound care · 2025 · Journal Article
Nair HK, Muangman P, Liu Y, Coleman K, et al.
Journal of the peripheral nervous system : JPNS · 2025 · Journal Article
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Health promotion international · 2025 · Journal Article
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Soins. Pediatrie, puericulture · 2025 · English Abstract
Hascoët C, Nguyen AT, Offroy M, Loué F, et al.
Arts & health · 2025 · Journal Article
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