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2 raisons identifiées
Auteur de référence en rhumatologie
24 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR ALIGHOLI NEDJAT-BAKHSH
88 AVENUE PARMENTIER, 75011 PARIS
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Climacteric : the journal of the International Menopause Society · 2020
Pain medicine (Malden, Mass.) · 2023
AbstractObjectiveTo evaluate the effectiveness of Tuina in relieving the pain, negative emotions, and disability of patients with knee osteoarthritis (KOA).DesignSingle-center, parallel, randomized controlled trial.SettingShanghai Guanghua Integrated Chinese and Western Medicine Hospital, Shanghai, China.SubjectsAdult patients with KOA who were able to speak Chinese and self-report symptoms were eligible.MethodsA total of 104 patients were randomly allocated to receive the 6-week treatment of Tuina (Tuina group) or celecoxib (celecoxib group). Data on pain, negative emotions, and disability were collected at baseline, at week 2, 4, and 6, and follow-up (1 month after the last treatment). The primary outcomes were the pressure pain thresholds. The secondary outcomes were: (1) numerical rating scale at rest and with movement; (2) Hamilton Anxiety Scale; (3) Hamilton Depression Scale; (4) Western Ontario and McMaster Universities Osteoarthritis Index; and (5) clinical effective rate. The adverse events of the trial were evaluated.ResultsIn total, 99 patients completed the follow-up. Generalized linear mixed models were constructed to analyse the between-group differences. Statistically significant differences were found in the interaction effects (P < .05). In evaluating the group effect, statistical differences were found at week 6 and follow-up (P < .05). Further, all variables showed a time effect (P < .05). A statistical difference in the clinical effective rate was found between the Tuina and celecoxib groups (P < .05).ConclusionsTuina produced superior effects for pain, negative emotions, and disability over time, as compared to celecoxib in patients with KOA.
Brain and behavior · 2022
Abstract Introduction Knee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long‐term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end‐stage KOA patients remain unclear. This study aimed to analyze the structural and functional connectivity alterations in end‐stage KOA to comprehensively understand the main brain‐associated mechanisms underlying its development and progression. Methods In this study, 37 patients with KOA and 37 demographically matched healthy controls (HCs) were enrolled. Alternations in gray matter (GM) volume in patients with KOA were determined using voxel‐based morphometry. The region with the largest GM volume alteration was selected as the region of interest to calculate the voxel‐wise resting‐state functional connectivity (rs‐FC) in the two groups. Pearson's correlation coefficient was used to analyze the correlation between clinical measures and GM volume alternations in patients with KOA. Results Compared with HCs, patients with KOAs exhibited significantly decreased GM volumes in the left middle temporal gyrus (left‐MTG) and the left inferior temporal gyrus. Results of the voxel‐wise rs‐FC analysis revealed that compared with HCs, patients with KOA had decreased left‐MTG rs‐FC to the right dorsolateral superior frontal gyrus, left middle frontal gyrus, and left medial superior frontal gyrus. GM volume in the left‐MTG was negatively correlated with the Western Ontario and McMaster Universities Arthritis Index in patients with KOA ( r = −0.393, p = .016). Conclusion Structural remodeling and functional connectivity alterations may be one of the central brain mechanisms associated with end‐stage KOA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Chinese medicine · 2025 · Journal Article
Bian Y, Li F, A X, Xiang Z, et al.
Scientific reports · 2025 · Journal Article
M C S, B K, A U, K C S
Biomacromolecules · 2024 · Journal Article
Kabir A, B M, A N, Selvaraj V, et al.
American journal of translational research · 2023 · Journal Article
A R, Mu R, Wu Q, Ga L, et al.
Metabolic brain disease · 2022 · Journal Article
Taghadosi Z, Zarifkar A, Razban V, Aligholi H
Journal of clinical medicine · 2021 · Journal Article
A G, Yano S, Sheik AM, Yu A, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020 · Journal Article
Safahani M, Aligholi H, Asadi-Pooya AA
Climacteric : the journal of the International Menopause Society · 2020 · Journal Article
Luo Y, Ma Y, Qiao X, Zeng R, et al.
Iranian journal of basic medical sciences · 2020 · Journal Article
Abdolahi S, Khodakaram-Tafti A, Aligholi H, Ziaei S, et al.
Neurobiology of disease · 2019 · Journal Article
Jafarian M, Modarres Mousavi SM, Alipour F, Aligholi H, et al.
Galen medical journal · 2019 · Journal Article
Zarifkar AH, Zarifkar A, Nami M, Rafati A, et al.
Iranian journal of basic medical sciences · 2018 · Journal Article
Ghasemi S, Aligholi H, Koulivand PH, Jafarian M, et al.
The British journal of occupational therapy · 2022 · Journal Article
Shamsi F, Nami M, Aligholi H, Borhani-Haghighi A, et al.
Clinical neurology and neurosurgery · 2021 · Journal Article
Aligholi H, Safahani M, Asadi-Pooya AA
The British journal of occupational therapy · 2022 · Journal Article
Shamsi F, Nami M, Aligholi H, Borhani-Haghighi A, et al.
Clinical neurology and neurosurgery · 2021 · Journal Article
Aligholi H, Safahani M, Asadi-Pooya AA
Clinical rheumatology · 2025 · Journal Article
A K, M EA, M H, H A, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2026 · Journal Article
Xin P, Li W, A X, Shen J, et al.
Cureus · 2024 · Case Reports
Ravichandran S, Kumar J, Chandrasekaran ND, Irfan S, et al.
Frontiers in pharmacology · 2023 · Journal Article
Ran L, Xu B, Han HH, Wang JY, et al.
JMIR research protocols · 2025 · Journal Article
M A, Ahmad A, A A, Raj LS, et al.
Pain medicine (Malden, Mass.) · 2023 · Randomized Controlled Trial
Xu H, Zhao C, Guo G, Li Y, et al.
Brain and behavior · 2022 · Journal Article
Kang BX, Ma J, Shen J, Xu H, et al.
Archives of osteoporosis · 2025 · Journal Article
N BV, A MS, A DR, H SG, et al.
Cureus · 2025 · Journal Article
Muraleedharan A, Chaubey S, A S, Yadav A
Pain medicine (Malden, Mass.) · 2023 · Randomized Controlled Trial
Xu H, Zhao C, Guo G, Li Y, et al.