📇 Rhumatologue · PARIS · (75) · Libéral

M Aligholi NEDJAT-BAKHSH

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Auteur de référence en rhumatologie
24 articles scientifiques publiés — un praticien à la pointe de la recherche
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336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS (75)LibéralRPPS 10000384726

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Irisin ameliorates bone loss in ovariectomized mice

Climacteric : the journal of the International Menopause Society · 2020

📚 34 citations🎯 RCR 2.29Top 23% NIH

The Effectiveness of Tuina in Relieving Pain, Negative Emotions, and Disability in Knee Osteoarthritis: A Randomized Controlled Trial

Pain medicine (Malden, Mass.) · 2023

📚 30 citations🎯 RCR 6.74Top 5% NIH🩺 Clinique

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AbstractObjectiveTo evaluate the effectiveness of Tuina in relieving the pain, negative emotions, and disability of patients with knee osteoarthritis (KOA).DesignSingle-center, parallel, randomized controlled trial.SettingShanghai Guanghua Integrated Chinese and Western Medicine Hospital, Shanghai, China.SubjectsAdult patients with KOA who were able to speak Chinese and self-report symptoms were eligible.MethodsA total of 104 patients were randomly allocated to receive the 6-week treatment of Tuina (Tuina group) or celecoxib (celecoxib group). Data on pain, negative emotions, and disability were collected at baseline, at week 2, 4, and 6, and follow-up (1 month after the last treatment). The primary outcomes were the pressure pain thresholds. The secondary outcomes were: (1) numerical rating scale at rest and with movement; (2) Hamilton Anxiety Scale; (3) Hamilton Depression Scale; (4) Western Ontario and McMaster Universities Osteoarthritis Index; and (5) clinical effective rate. The adverse events of the trial were evaluated.ResultsIn total, 99 patients completed the follow-up. Generalized linear mixed models were constructed to analyse the between-group differences. Statistically significant differences were found in the interaction effects (P &lt; .05). In evaluating the group effect, statistical differences were found at week 6 and follow-up (P &lt; .05). Further, all variables showed a time effect (P &lt; .05). A statistical difference in the clinical effective rate was found between the Tuina and celecoxib groups (P &lt; .05).ConclusionsTuina produced superior effects for pain, negative emotions, and disability over time, as compared to celecoxib in patients with KOA.

Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging

Brain and behavior · 2022

📚 22 citations🎯 RCR 2.91Top 17% NIH🔓 Open Access

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Abstract Introduction Knee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long‐term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end‐stage KOA patients remain unclear. This study aimed to analyze the structural and functional connectivity alterations in end‐stage KOA to comprehensively understand the main brain‐associated mechanisms underlying its development and progression. Methods In this study, 37 patients with KOA and 37 demographically matched healthy controls (HCs) were enrolled. Alternations in gray matter (GM) volume in patients with KOA were determined using voxel‐based morphometry. The region with the largest GM volume alteration was selected as the region of interest to calculate the voxel‐wise resting‐state functional connectivity (rs‐FC) in the two groups. Pearson's correlation coefficient was used to analyze the correlation between clinical measures and GM volume alternations in patients with KOA. Results Compared with HCs, patients with KOAs exhibited significantly decreased GM volumes in the left middle temporal gyrus (left‐MTG) and the left inferior temporal gyrus. Results of the voxel‐wise rs‐FC analysis revealed that compared with HCs, patients with KOA had decreased left‐MTG rs‐FC to the right dorsolateral superior frontal gyrus, left middle frontal gyrus, and left medial superior frontal gyrus. GM volume in the left‐MTG was negatively correlated with the Western Ontario and McMaster Universities Arthritis Index in patients with KOA ( r = −0.393, p = .016). Conclusion Structural remodeling and functional connectivity alterations may be one of the central brain mechanisms associated with end‐stage KOA.

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M Aligholi NEDJAT-BAKHSH

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Top publications · les plus citées

Publications scientifiques (24) — classées par pathologie

Transversal13

Revue / méta-analyse2

Revue générale2

Arthrite juvénile1

Biomarqueurs / Auto-Ac1

Case report / série1

csDMARDs1

Épidémiologie & registres1

Essai clinique1

IRM ostéo-articulaire1

Ostéoporose1

Qualité de vie / PROMs1

Vraie vie / RWE1

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