📇 Rhumatologue · PARIS CEDEX 13 · (75) · Hospitalier

M VINCENT NAVARRO

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6 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
23 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Expérience confirmée
23 ans d'exercice en rhumatologie — recul clinique solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS CEDEX 13 (75)HospitalierRPPS 10001413292

EnseignementExpérience confirmée

23ans d'exercice (thèse 2003)

📊 Reconnaissance scientifique : 57/100📝 325 articles publiés🇫🇷 Publications académiques françaises (8)🎓 6 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Vitamin D deficiency and effect of treatment on seizure frequency and quality of life parameters in patients with drug-resistant epilepsy: A randomized clinical trial

Epilepsia · 2024

📚 12 citations🎯 RCR 4.09Top 10% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractObjectiveThis study was undertaken to assess the effect of treatment of vitamin D deficiency in drug‐resistant epilepsy.MethodsWe conducted a multicenter, double‐blind, placebo‐controlled, randomized clinical trial, including patients aged ≥15 years with drug‐resistant focal or generalized epilepsy. Patients with 25‐hydroxyvitamin D (25[OH]D) < 30 ng/mL were randomized to an experimental group (EG) receiving vitamin D3 (cholecalciferol, 100 000 IU, five doses in 3 months) or a control group (CG) receiving matched placebo. During the open‐label study, EG patients received 100 000 IU/month for 6 months, whereas CG patients received five doses in 3 months then 1/month for 3 months. Monitoring included seizure frequency (SF), 25(OH)D, calcium, albumin, creatinine assays, and standardized scales for fatigue, anxiety–depression, and quality of life (Modified Fatigue Impact Scale [M‐FIS], Hospital Anxiety and Depression Scale, Quality of Life in Epilepsy [QOLIE‐31]) at 3, 6, and 12 months. The primary efficacy outcome was the percentage of SF reduction compared to the reference period and CG at 3 months. Secondary outcomes were SF and bilateral tonic–clonic seizure (BTCS) reduction, scale score changes, and correlations with 25(OH)D during the follow‐up.ResultsEighty‐eight patients were enrolled in the study (56 females, aged 17–74 years), with median baseline SF per 3 months = 16.5 and ≥2 antiseizure medications in 88.6%. In 75 patients (85%), 25(OH)D was <30 ng/mL; 40 of them were randomly assigned to EG and 34 to CG. After the 3‐month blinded period, SF reduction did not significantly differ between groups. However, during the open‐label period, SF significantly decreased (30% median SF reduction, 33% responder rate at 12 months). BTCSs were reduced by 52%. M‐FIS and QOLIE‐31 scores were significantly improved at the whole group level. SF reduction correlated with 25(OH)D > 30 ng/mL for >6 months.SignificanceDespite no proven effect after the 3‐month blinded period, the open‐label study suggests that long‐term vitamin D3 supplementation with optimal 25(OH)D may reduce SF and BTCSs, with a positive effect on fatigue and quality of life. These findings need to be confirmed by further long‐term studies.Trial Registration ClinicalTrials.gov identifier: NCT03475225 (03‐22‐2018).

Burden of status epilepticus: prognosis and cost driving factors, insight from a nationwide retrospective cohort study of the French health insurance database

Journal of neurology · 2024

📚 8 citations🎯 RCR 2.77Top 18% NIH🔓 Open Access📄 PDF gratuit ↗

The Lancet. Neurology · 2026

📚 6 citations🎯 RCR 6.00🔓 Open Access📄 PDF gratuit ↗

Cookies & analyse de trafic

M VINCENT NAVARRO

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Direction de thèses

Activité de recherche & publications

Publications académiques en France

Lieux de consultation(2)

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (23) — classées par pathologie

Transversal11

Épidémiologie & registres3

Essai clinique2

Revue générale2

Santé mentale / fatigue2

Biomarqueurs / Auto-Ac1

Économie santé1

Génétique1

Pharmacovigilance1

Qualité de vie / PROMs1

Recommandations1

Vraie vie / RWE1

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