📇 Rhumatologue ·

MME FABIENNE NAVARRO

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Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10000620541

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

Annals of the rheumatic diseases · 2013

📚 210 citations🎯 RCR 8.53Top 3% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project

Annals of the rheumatic diseases · 2011

📚 127 citations🎯 RCR 5.15Top 7% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

Arthritis and rheumatism · 2008

📚 78 citations🎯 RCR 1.52

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AbstractObjectivePrevious studies have shown either a lack of effect of IRF5 polymorphisms or an association of the IRF5 gene in only a minor subset of rheumatoid arthritis (RA) patients in whom anti–citrullinated protein antibodies (ACPAs) are absent. The present study was undertaken to investigate the role of genetic variation in IRF5 in susceptibility to RA.MethodsNine IRF5 single‐nucleotide polymorphisms (SNPs) were studied in 1,338 patients with RA and 1,342 control subjects in analyses of exploratory and replication sample collections, with stratification according to sex and by the presence or absence of ACPAs, rheumatoid factor, the shared epitope, the 620W PTPN22 allele, and erosions. A meta‐analysis that included results from previous studies was also carried out.ResultsOur findings together with those from previous studies, in a total of 4,620 RA patients and 3,741 controls, showed a significant association of the rs2004640 IRF5 SNP in RA patients as a whole (odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.83–0.94; P = 6.5 × 10−5 versus controls). This association was stronger in ACPA− patients, but was also present in ACPA+ patients (from 3 sample collections). Further analysis of our exploratory sample collection showed that only patients in the ACPA+ and SE− group lacked an association with IRF5 SNPs. All of the remaining RA patients (ACPA− or SE+) showed a strong association with IRF5 SNPs, which followed a complex pattern of opposing effects mediated by independent haplotypes. The susceptibility haplotype showed an OR of 1.8 (95% CI 1.4–2.3; P = 1.2 × 10−6 versus controls), whereas the protective haplotype showed an OR of 0.76 (95% CI 0.6–0.98; P = 0.046 versus controls).ConclusionIRF5 polymorphisms seem to influence RA susceptibility in a large subgroup of patients, following a pattern of association very similar to that described in patients with systemic lupus erythematosus.

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MME FABIENNE NAVARRO

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Top publications · les plus citées

Publications scientifiques (30) — classées par pathologie

Biothérapies non-anti-TNF8

Transversal6

Essai clinique4

Lupus3

Pharmacovigilance3

csDMARDs2

Génétique2

AINS1

Anti-TNF1

Arthrose1

Biomarqueurs / Auto-Ac1

IA en rhumatologie1

JAK inhibiteurs1

Qualité de vie / PROMs1

Revue / méta-analyse1

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