📇 Rhumatologue · PARIS · (75) · Hospitalier

M ANTOINE MOULIGNIER

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4 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Praticien-chercheur
17 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS (75)HospitalierRPPS 10000485952

📊 Reconnaissance scientifique : 24/100📝 99 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis

JAMA neurology · 2020

📚 351 citations🎯 RCR 18.69Top 1% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Central nervous system immune reconstitution disease in acquired immunodeficiency syndrome patients receiving highly active antiretroviral treatment

Journal of neurovirology · 2005

📚 103 citations🎯 RCR 2.58Top 20% NIH🔓 Open Access

Peripheral neuropathy in human immunodeficiency virus-infected patients with the diffuse infiltrative lymphocytosis syndrome

Annals of neurology · 1997

📚 58 citations🎯 RCR 1.95

Lire l'abstract Crossref ↓

AbstractA subset of human immunodeficiency virus (HIV)‐infected patients develop persistent CD8 hyperlymphocytosis and a Sjögren's syndrome‐like syndrome associated with multivisceral CD8 T‐cell infiltration, known as the diffuse infiltrative lymphocytosis syndrome (DILS). Patients with DILS tend to have higher CD4 cell counts, fewer opportunistic infections, and longer survival times than other HIV‐infected patients. Peripheral nerve involvement in DILS has been poorly documented. We studied 12 HIV‐infected patients with CD8 hyperlymphocytosis, DILS, and clinical signs of peripheral neuropathy. Two of 4 patients who were HLA typed were HLA‐DR5 and 1 was HLA‐DR6. All patients had the sicca syndrome and multivisceral involvement. The neuropathy was acute or subacute, always painful, and symmetrical in 8 cases. Electrophysiology was consistent with axonal neuropathy in 10 of 12 patients. Nerve biopsy showed marked angiocentric CD8 infiltrates without mural necrosis (12 of 12), and abundant expression of HIV p24 protein in macrophages (12 of 12). The HIV genome was detected by polymerase chain reaction in nerve homogenates. Zidovudine therapy was associated with improvement in 6 of 6 patients and steroid therapy was beneficial in 4 of 5 patients. No T‐cell lymphoma was observed during follow‐up, but 2 patients developed a primary B‐cell lymphoma. We conclude that DILS neuropathy represents HIV‐associated neuropathy, characterized by marked CD8 infiltration and abundant HIV in nerve, that improves with zidovudine or steroid therapy, and probably reflects a systemic host‐determined and antigendriven response to HIV.

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M ANTOINE MOULIGNIER

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieux de consultation(2)

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (17) — classées par pathologie

Transversal14

Case report / série1

csDMARDs1

Risque cardio-vasculaire1

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