📇 Rhumatologue · VILLEMOISSON SUR ORGE · (91) · Libéral

M Jean-Francois MORVAN

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17 articles scientifiques publiés — formation continue solide
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73.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 VILLEMOISSON SUR ORGE (91)LibéralRPPS 10000867258

🇫🇷 Publications académiques françaises (5)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

Observances franciscaines et dynamiques institutionnelles
2025
Chapitre

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

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Improvement of Sjögren's syndrome after two infusions of rituximab (anti-CD20)

Arthritis and rheumatism · 2007

📚 238 citations🎯 RCR 6.31Top 5% NIH🩺 Clinique

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AbstractObjectiveThere is evidence to support a dominant role for B cells in the pathophysiology of primary Sjögren's syndrome (SS). Therefore, we evaluated the safety and efficacy of anti‐CD20 monoclonal antibody.MethodsSixteen patients who met the new American‐European Consensus Group criteria for primary SS and scored >50 on at least 2 of 4 visual analog scales (VAS; 100 mm) evaluating global disease, pain, fatigue, and global dryness received infusions of low‐dose rituximab (375 mg/m2) at weeks 0 and 1 without steroid premedication.ResultsSlow rituximab infusions (100 mg/hour) were well tolerated, with only 1 patient experiencing serum sickness–like disease. There was a dramatic reduction in B cells of the blood and salivary gland (SG). At week 12, VAS scores with respect to fatigue and dryness (P < 0.05), tender point count (P < 0.035), and quality of life as evaluated by the Short Form 36 questionnaire (SF‐36; P < 0.001) were significantly improved. At week 36, significant improvements were noted in the 4 VAS scores (P < 0.05), tender joint count (P = 0.017), tender point count (P = 0.027), and SF‐36 (P < 0.03). Pulmonary manifestations were ameliorated in 1 patient. Patients with improvements on at least 3 of the 4 VAS scores at any visit (n = 11) had a shorter disease duration than the other patients (n = 5; mean ± SD duration 3.8 ± 5.4 versus 30.1 ± 29.5 years; P = 0.02).ConclusionLow‐dose rituximab infusions were well tolerated without the benefit of steroids. Infusions induced a rapid depletion of B cells in the blood and SG and could improve primary SS. Controlled studies are needed.

Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey

Osteoarthritis and cartilage · 2011

📚 129 citations🎯 RCR 5.50Top 7% NIH🔓 Open Access📄 PDF gratuit ↗

Screening for hip and knee osteoarthritis in the general population: predictive value of a questionnaire and prevalence estimates

Annals of the rheumatic diseases · 2008

📚 83 citations🎯 RCR 2.92Top 17% NIH

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M Jean-Francois MORVAN

Pourquoi vous devez consulter ce praticien

Publications académiques en France

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Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (17) — classées par pathologie

Transversal8

Épidémiologie & registres5

Sjögren4

Biothérapies non-anti-TNF3

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