📇 Rhumatologue · ST QUENTIN CEDEX · (02) · Salarié

MME Pia MICHEL-VERNIER

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Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche
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84.6 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 ST QUENTIN CEDEX (02)SalariéRPPS 10000736123

✨ Génération du profil synthétique IA en cours…

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HOPITAL PRIVE SAINT CLAUDE
1 BD DU DOCTEUR SCHWEITZER CS 90448, 02315 ST QUENTIN CEDEX
☎ 0323645002Activité de soin et de pharmacie

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Top publications · les plus citées

Systematic review and co-ordinate based meta-analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization

European journal of pain (London, England) · 2024

📚 9 citations🎯 RCR 2.38Top 22% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackground and ObjectiveFunctional magnetic resonance imaging, in conjunction with models of peripheral and/or central sensitization, has been used to assess analgesic efficacy in healthy humans. This review aims to summarize the use of these techniques to characterize brain mechanisms of hyperalgesia/allodynia and to evaluate the efficacy of analgesics.Databases and Data TreatmentSearches were performed (PubMed‐Medline, Cochrane, Web of Science and Clinicaltrials.gov) to identify and review studies. A co‐ordinate based meta‐analysis (CBMA) was conducted to quantify neural activity that was reported across multiple independent studies in the hyperalgesic condition compared to control, using GingerALE software.ResultsOf 217 publications, 30 studies met the inclusion criteria. They studied nine different models of hyperalgesia/allodynia assessed in the primary (14) or secondary hyperalgesia zone (16). Twenty‐three studies focused on neural correlates of hyperalgesic conditions and showed consistent changes in the somatosensory cortex, prefrontal cortices, insular cortex, anterior cingulate cortex, thalamus and brainstem. The CBMA on 12 studies that reported activation coordinates for a contrast comparing the hyperalgesic state to control produced six activation clusters (significant at false discovery rate of 0.05) with more peaks for secondary (17.7) than primary zones (7.3). Seven studies showed modulation of brain activity by analgesics in five of the clusters but also in four additional regions.ConclusionsThis meta‐analysis revealed substantial but incomplete overlap between brain areas related to neural mechanisms of hyperalgesia and those reflecting the efficacy of analgesic drugs. Studies testing in the secondary zone were more sensitive to evaluate analgesic efficacy on central sensitization at brainstem or thalamocortical levels.SignificanceExperimental pain models that provide a surrogate for features of pathological pain conditions in healthy humans and functional imaging techniques are both highly valuable research tools. This review shows that when used together, they provide a wealth of information about brain activity during pain states and analgesia. These tools are promising candidates to help bridge the gap between animal and human studies, to improve translatability and provide opportunities for identification of new targets for back‐translation to animal studies.

Increased Allergic Rhinitis Prevalence and Symptom Severity in Patients With Irritable Bowel Syndrome

Neurogastroenterology and motility · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

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ABSTRACT Background Patients with irritable bowel syndrome (IBS) have an increased risk of developing both airway and allergic diseases. However, the relationship between allergic rhinitis (AR), one of the most common chronic upper airway inflammatory diseases, and IBS remains poorly understood. The aim of this study is to provide a better understanding of airway complications in patients with IBS and to evaluate the presence of potential airborne and dietary antigen cross‐reactivity in concomitant IBS and AR. Methods A total of 287 participants, 54 healthy volunteers without gastrointestinal complaints and 232 patients with I fulfilling Rome IV criteria, were invited to complete self‐administered questionnaires assessing the severity of upper airway symptoms and the prevalence of allergic rhinitis. Results Overall, patients with IBS had a threefold higher risk of questionnaire‐based allergic rhinitis than control subjects (95% CI, 1.49–6.12). Furthermore, patients with IBS + AR showed reduced sleep quality, mood, and personal satisfaction associated with their upper airway complaints, compared to IBS patients without AR. Forty‐seven (18/38) percent of IBS + AR patients reported IBS symptoms in response to ingestion of food items with molecular mimicry of the aeroallergen to which the patient is sensitized. Conclusion Our study shows that patients with IBS have an increased frequency of concomitant allergic rhinitis, which contributes to a further reduction in quality of life. We also provide evidence of potential cross‐reactive reactions between aeroallergens and dietary antigens in patients with concomitant IBS and AR.

Distortion errors characterise visuo-constructive performance in Huntington's disease

The Clinical neuropsychologist · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

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MME Pia MICHEL-VERNIER

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Top publications · les plus citées

Publications scientifiques (26) — classées par pathologie

Transversal10

Épidémiologie & registres4

Revue générale4

Case report / série3

Pharmacovigilance3

Revue / méta-analyse3

Santé mentale / fatigue2

Essai clinique1

Lupus1

Ostéoporose1

Pédiatrie1

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