📇 Rhumatologue · SURESNES · (92) · Libéral

M Olivier MICHEL

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
136 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 SURESNES (92)LibéralRPPS 10000961945

📊 Reconnaissance scientifique : 31/100📝 423 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

TESS3: fast inference of spatial population structure and genome scans for selection

Molecular ecology resources · 2016

📚 168 citations🎯 RCR 7.23Top 4% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractGeography and landscape are important determinants of genetic variation in natural populations, and several ancestry estimation methods have been proposed to investigate population structure using genetic and geographic data simultaneously. Those approaches are often based on computer‐intensive stochastic simulations and do not scale with the dimensions of the data sets generated by high‐throughput sequencing technologies. There is a growing demand for faster algorithms able to analyse genomewide patterns of population genetic variation in their geographic context. In this study, we presentTESS3, a major update of the spatial ancestry estimation programTESS. By combining matrix factorization and spatial statistical methods,TESS3provides estimates of ancestry coefficients with accuracy comparable toTESSand with run‐times much faster than the Bayesian version. In addition, theTESS3program can be used to perform genome scans for selection, and separate adaptive from nonadaptive genetic variation using ancestral allele frequency differentiation tests. The main features ofTESS3are illustrated using simulated data and analysing genomic data from European lines of the plant speciesArabidopsis thaliana.

Usefulness of cardiothoracic chest ultrasound in the management of acute respiratory failure in critical care practice

Chest · 2013

📚 70 citations🎯 RCR 2.99Top 16% NIH

Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction

Pediatric pulmonology · 2005

📚 69 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractExercise‐induced asthma (EIA) is a possible cause of poor physical performance in children. No data are available on the value of respiratory symptoms to discriminate children with bad physical fitness from children with EIA. We evaluated respiratory symptoms in school‐age children during and after exercise in relation to EIA. The population of 149 primary schools (849 classes with 15,241 children) was enrolled in the study. EIB was assessed using the 6‐min free‐running‐test (6MFRT) in 15,241 children. At the end or at premature arrest of the 6MFRT, signs reported by the children and clinical symptoms observed by supervising physicians were recorded. Peak flow measurements were obtained before and 5 and 10 min after the 6MFRT, a decrease of 15% or more being defined as significant. The 6MFRT was positive in 7.4% of primary schoolchildren. Girls were more likely to have a positive test than boys (8.5% vs. 6.4%,P < 0.001), and children living in urban areas more than those living in rural areas (8.9% vs. 7.0%,P < 0.01). Premature arrest was seen in 3.5% (i.e., n = 353) of the children. The main reasons for premature arrest were dyspnea and chest pain. Among them, only 21% had a positive 6MFRT, while 89% with a positive 6MFRT could terminate the test. Premature arrest, breathlessness, chest tightness, wheezing, and cough had a positive predictive value to detect a EIA of 21.9%, 20.8%, 36.4%, 41.2%, and 28.3%, respectively, and a sensitivity of 10.8%, 29.5%, 14.9%, 4.8%, and 13.0%, respectively. In conclusion, EIA was detected in 7.4% of schoolchildren. A slightly higher incidence was observed in girls and children from an urban area. Neither premature arrest nor clinical signs and symptoms were good predictors of EIA in primary schoolchildren. Pediatr Pulmonol. 2005; 39:301–305. © 2005 Wiley‐Liss, Inc.

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M Olivier MICHEL

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Activité de recherche & publications

Publications académiques en France

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Publications scientifiques (50) — classées par pathologie

Transversal42

Épidémiologie & registres2

Anti-TNF1

Essai clinique1

Génétique1

Goutte1

Pédiatrie1

Revue / méta-analyse1

Revue générale1

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