📇 Rhumatologue · HAGUENAU · (67) · Salarié

M PATRIC MEYER

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33 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 HAGUENAU (67)SalariéRPPS 10002420981

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Inflammatory disease processes and interactions with nutrition

The British journal of nutrition · 2009

📚 355 citations🎯 RCR 11.31Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

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Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infected or damaged sites. Acute inflammatory reactions are usually self-limiting and resolve rapidly, due to the involvement of negative feedback mechanisms. Thus, regulated inflammatory responses are essential to remain healthy and maintain homeostasis. However, inflammatory responses that fail to regulate themselves can become chronic and contribute to the perpetuation and progression of disease. Characteristics typical of chronic inflammatory responses underlying the pathophysiology of several disorders include loss of barrier function, responsiveness to a normally benign stimulus, infiltration of inflammatory cells into compartments where they are not normally found in such high numbers, and overproduction of oxidants, cytokines, chemokines, eicosanoids and matrix metalloproteinases. The levels of these mediators amplify the inflammatory response, are destructive and contribute to the clinical symptoms. Various dietary components including long chain ω-3 fatty acids, antioxidant vitamins, plant flavonoids, prebiotics and probiotics have the potential to modulate predisposition to chronic inflammatory conditions and may have a role in their therapy. These components act through a variety of mechanisms including decreasing inflammatory mediator production through effects on cell signaling and gene expression (ω-3 fatty acids, vitamin E, plant flavonoids), reducing the production of damaging oxidants (vitamin E and other antioxidants), and promoting gut barrier function and anti-inflammatory responses (prebiotics and probiotics). However, in general really strong evidence of benefit to human health through anti-inflammatory actions is lacking for most of these dietary components. Thus, further studies addressing efficacy in humans linked to studies providing greater understanding of the mechanisms of action involved are required.

Risk of non-Hodgkin's lymphoma in primary Sjögren's syndrome: a population-based study

Arthritis care & research · 2013

📚 65 citations🎯 RCR 2.29Top 23% NIH

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AbstractObjectivePrimary Sjögren's syndrome (SS) is associated with an increased risk of non‐Hodgkin's lymphoma (NHL), but the reported prevalence and risk vary considerably. The objective of this study was to determine the risk of NHL in a well‐defined population‐based primary SS cohort in Norway.MethodsThe authors examined all patients fulfilling the American–European Consensus Group criteria for primary SS from 2 Norwegian counties and compared the data to the Cancer Registry of Norway to identify the primary SS patients who had lymphoma. In addition, lymphoma patient files from the same period were reviewed for undiagnosed primary SS to ensure the quality of registry data.ResultsAs of July 1, 2009, 443 living subjects with primary SS were identified in an area with 896,840 inhabitants, which is 18.6% of the total population of Norway. Seven cases of NHL (1.6%) were found during a total followup of 3,813 person‐years, resulting in a standardized incidence ratio of 9.0 (95% confidence interval 7.1–26.3) for NHL in primary SS patients.ConclusionThe risk of NHL in patients with primary SS in Norway is increased 9 times compared with the general population. This is in accordance with recent studies, and the quality and completeness of the registries and strict use of diagnostic criteria support the validity of the results.

On the role of knee joint in balance control and postural strategies: effects of total knee replacement in elderly subjects with knee osteoarthritis

Gait & posture · 2010

📚 61 citations🎯 RCR 2.73Top 18% NIH

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Publications scientifiques (33) — classées par pathologie

Transversal14

csDMARDs2

Essai clinique2

Gériatrie2

IRM ostéo-articulaire2

Revue / méta-analyse2

Revue générale2

Anti-IL-231

Arthrite juvénile1

Biomarqueurs / Auto-Ac1

Économie santé1

Génétique1

Qualité de vie / PROMs1

Risque cardio-vasculaire1

Sjögren1

Vascularites1

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