📇 Rhumatologue · LES ORRES · (05) · Libéral

M STEPHANE MEGARNI

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 4 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
184.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LES ORRES (05)LibéralRPPS 10001850485

✨ Génération du profil synthétique IA en cours…

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CABINET STEPHANE MEGARNI
CABINET MEDICAL 13 PLACE EMILE HODOUL, 05200 LES ORRES
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Top publications · les plus citées

A Review of the Regulatory Challenges of Personalized Medicine

Cureus · 2024

📚 11 citations🎯 RCR 2.24Top 23% NIH🔓 Open Access📄 PDF gratuit ↗

The European Nucleotide Archive in 2025

Nucleic acids research · 2026

📚 7 citations🎯 RCR 7.00🔓 Open Access

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Abstract The European Nucleotide Archive (ENA; https://www.ebi.ac.uk/ena), hosted at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), remains a global, open-access platform for the submission, archiving, dissemination, and reuse of nucleotide sequence data. In 2025, ENA continues to advance its mission of fostering FAIR (findable, accessible, interoperable, reusable) data principles through innovations in interoperability, scalability, and global engagement, providing infrastructure for a rapidly growing volume of data across diverse domains. This article highlights the key developments in 2025, including the progress of the technical transformation, enhanced support for large-scale biodiversity projects, and the implementation of the International Nucleotide Sequence Database Collaboration Global Participation Initiative. We also discuss infrastructure enhancements to handle exponential data growth and improve user experiences and data discovery.

Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach

PloS one · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

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Background Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets. Methodology Ten microarray datasets each for RA, and IBD, and nine datasets for dementia were obtained from Gene Expression Omnibus. We identified common differentially expressed genes (DEGs) and constructed a gene-gene interaction network. Subsequently, topology analysis for hub gene identification, cluster and functional enrichment, and regulatory network analysis were performed. The hub genes were then validated using independent microarray datasets from Gene Expression Omnibus. Results A total of 198 common DEGs were identified from which CD44, FN1, IGF1, COL1A2, and POSTN were identified as the hub genes in our study. These hub genes were mostly enriched in significant processes and pathways like tissue development, collagen binding, cell adhesion, regulation of ERK1/2 cascade, PI3K-AKT signaling, and cell surface receptor signaling. Key transcription factors TWIST2, CEBPA, EP300, HDAC1, HDAC2, NFKB1, RELA, TWIST1, and YY1 along with the miRNA hsa-miR-29 were found to regulate the expression of the hub genes significantly. Among these regulatory molecules, miR-29 emerged as a significant linker molecule, bridging the molecular mechanisms of RA, IBD, and dementia. Validation of our hub genes demonstrated a similar expression trend in the independent datasets used for our study. Conclusion Our study underscores the significant role of miR-29 in modulating the expression of hub genes and the associated transcription factors, which are crucial in the comorbidity status of RA, dementia, and IBD. This regulatory mechanism highlights miR-29 as a key player in the pathogenesis of these comorbid diseases.

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M STEPHANE MEGARNI

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Articles de presse (4)

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal29

Revue générale6

Case report / série4

Épidémiologie & registres3

Revue / méta-analyse3

csDMARDs1

Économie santé1

Essai clinique1

Génétique1

IRM ostéo-articulaire1

Lupus1

Ostéoporose1

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

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