📇 Rhumatologue · PARIS · (75) · Libéral
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Praticien-chercheur
9 articles scientifiques publiés — formation continue solide
Disponibilité géographique
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336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CDS MEDICAL RAMSAY SANTE AUBER
9 R BOUDREAU, 75009 PARIS
CABINET DU DR FATIHA MASSEN-FOUDA
LOCAL B 52 BOULEVARD VICTOR HUGO, 77220 GRETZ ARMAINVILLIERS
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Lupus · 2008
Mycophenolate mofetil (MMF) with prednisolone has been associated with high remission rates when used as induction treatment for lupus nephritis. This prospective, multicentre, cohort study investigates the efficacy and safety of this regimen over 24 weeks in 213 Chinese patients with active lupus nephritis (Classes III, IV, V or combination). Baseline activity index (AI) was 6.91 ± 3.33 and chronicity index (CI) was 1.9 ± 1.2. The remission rate was 82.6% at 24 weeks (complete remission, 34.3%; partial remission, 48.4%). There were significant ( P < 0.01) improvements in kidney function shown by reductions in proteinuria, serum albumin, serum creatinine and creatinine clearance, as well as in systemic lupus erythematosus disease activity index (SLEDAI) scores. Independent risk factors influencing remission were pathological classification (including Class V and III or Class V and IV nephritis) and elevated serum creatinine at baseline (OR 2.967, 95% CI: 1.479–6.332, P = 0.001 and OR 1.007, 95% CI: 1.002–1.011, P = 0.001, respectively). Patients with concomitant membranous features on biopsy had a lower remission rate than those with Class III and IV nephritis (66.7% vs 87.3%, P = 0.002). Renal biopsy was repeated in 25 patients following treatment. There was a transition to less severe pathological morphologies in majority of subjects. Infections were monitored throughout treatment: eight patients (3.8%) experienced bacterial infections, whereas herpes zoster occurred in seven patients. Nine patients (4.2%) suffered from gastrointestinal upset, which resolved without discontinuation of MMF. One patient became leucopenic, whereas another died from active disease unrelated to kidney symptoms. MMF combined with prednisolone is an effective and well-tolerated induction treatment for patients with active lupus nephritis and for controlling SLE systemic activity.
Journal of cellular and molecular medicine · 2017
AbstractIslet transplantation is associated with early ischaemia/reperfusion, localized coagulation and redox‐sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated protein C (aPC) restores islet vascularization and protects graft function, suggesting that aPC triggers various lineages. aPC also prompts the release of endothelial MP that bear EPCR, its specific receptor. Microparticles (MP) are plasma membrane procoagulant vesicles, surrogate markers of stress and cellular effectors. We measured the cytoprotective effects of aPC on endothelial and insulin‐secreting Rin‐m5f β‐cells and its role in autocrine and paracrine MP‐mediated cell crosstalk under conditions of oxidative stress. MP from aPC‐treated primary endothelial (EC) or β‐cells were applied to H2O2‐treated Rin‐m5f. aPC activity was measured by enzymatic assay and ROS species by dihydroethidium. The capture of PKH26‐stained MP and the expression of EPCR were probed by fluorescence microscopy and apoptosis by flow cytometry. aPC treatment enhanced both annexin A1 (ANXA1) and PAR‐1 expression in EC and to a lesser extent in β‐cells. MP from aPC‐treated EC (eMaPC) exhibited high EPCR and annexin A1 content, protected β‐cells, restored insulin secretion and were captured by 80% of β cells in a phosphatidylserine and ANXA1‐dependent mechanism. eMP activated EPCR/PAR‐1 and ANXA1/FPR2‐dependent pathways and up‐regulated the expression of EPCR, and of FPR2/ALX, the ANXA1 receptor. Cytoprotection was confirmed in H2O2‐treated rat islets with increased viability (62% versus 48% H2O2), reduced apoptosis and preserved insulin secretion in response to glucose elevation (16 versus 5 ng/ml insulin per 10 islets). MP may prove a promising therapeutic tool in the protection of transplanted islets.
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Drug design, development and therapy · 2019 · Journal Article
Kameoka Y, F K, M K
Journal of cellular and molecular medicine · 2017 · Journal Article
Kreutter G, Kassem M, El Habhab A, Baltzinger P, et al.
The Pan African medical journal · 2016 · Case Reports
Fatiha EA, Abdeljalil C, Ilham K, Nawal B, et al.
Discover mental health · 2026 · Journal Article
Aymen K, Majda S, Saadia K, Imane A, et al.
Alpha psychiatry · 2024 · Journal Article
Kachouchi A, Ahmed L, Saadia K, Imane A, et al.
Annales de cardiologie et d'angeiologie · 2023 · Journal Article
Abdeslam EK, Ahmed C, Kamal K, Rachid L, et al.
Annals of medicine and surgery (2012) · 2021 · Case Reports
Ely Cheikh T, Fatiha E, Khadija I, Malak C, et al.
Lupus · 2008 · Clinical Trial
F L, Y T, X P, L W, et al.
BMJ case reports · 2026 · Journal Article
F A, George OK, Alex AG, Sahitya MS
Discover mental health · 2026 · Journal Article
Aymen K, Majda S, Saadia K, Imane A, et al.