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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
✨ Génération du profil synthétique IA en cours…
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Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 France 24 · 01/12/2019
<a href="https://news.google.com/rss/articles/CBMizwFBVV95cUxNLWRMaktraDFiZElMQ3dPZnhqLWdveUFSRlhmbFhvSmtSbGZFVDFleHE2cG5hZk5DVWNzMFBRNl9kQXliZ3BVVjNLYWJoaGxrOFl1SnMtREFlTjQxV0U1RTJ1YTJYWE90dlJfdzZOaHhmYUxFT01FNThRcXJheUVSbExyMERnU1FLZk1zNFNTOWVTa19zbnRQazR6YlVOdFZPTEozNldDWUdwMzVuWUIycTZib0JVZ3FheT
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012
Abstract Zoledronic acid 5 mg (ZOL) annually for 3 years reduces fracture risk in postmenopausal women with osteoporosis. To investigate long-term effects of ZOL on bone mineral density (BMD) and fracture risk, the Health Outcomes and Reduced Incidence with Zoledronic acid Once Yearly–Pivotal Fracture Trial (HORIZON-PFT) was extended to 6 years. In this international, multicenter, double-blind, placebo-controlled extension trial, 1233 postmenopausal women who received ZOL for 3 years in the core study were randomized to 3 additional years of ZOL (Z6, n = 616) or placebo (Z3P3, n = 617). The primary endpoint was femoral neck (FN) BMD percentage change from year 3 to 6 in the intent-to-treat (ITT) population. Secondary endpoints included other BMD sites, fractures, biochemical bone turnover markers, and safety. In years 3 to 6, FN-BMD remained constant in Z6 and dropped slightly in Z3P3 (between-treatment difference = 1.04%; 95% confidence interval 0.4 to 1.7; p = 0.0009) but remained above pretreatment levels. Other BMD sites showed similar differences. Biochemical markers remained constant in Z6 but rose slightly in Z3P3, remaining well below pretreatment levels in both. New morphometric vertebral fractures were lower in the Z6 (n = 14) versus Z3P3 (n = 30) group (odds ratio = 0.51; p = 0.035), whereas other fractures were not different. Significantly more Z6 patients had a transient increase in serum creatinine &gt;0.5 mg/dL (0.65% versus 2.94% in Z3P3). Nonsignificant increases in Z6 of atrial fibrillation serious adverse events (2.0% versus 1.1% in Z3P3; p = 0.26) and stroke (3.1% versus 1.5% in Z3P3; p = 0.06) were seen. Postdose symptoms were similar in both groups. Reports of hypertension were significantly lower in Z6 versus Z3P3 (7.8% versus 15.1%, p &lt; 0.001). Small differences in bone density and markers in those who continued versus those who stopped treatment suggest residual effects, and therefore, after 3 years of annual ZOL, many patients may discontinue therapy up to 3 years. However, vertebral fracture reductions suggest that those at high fracture risk, particularly vertebral fracture, may benefit by continued treatment. (ClinicalTrials.gov identifier: NCT00145327). © 2012 American Society for Bone and Mineral Research
The Journal of experimental medicine · 2012
B cell tolerance to self-antigen is critical to preventing antibody-mediated autoimmunity. Previous work using B cell antigen receptor transgenic animals suggested that self-antigen–specific B cells are either deleted from the repertoire, enter a state of diminished function termed anergy, or are ignorant to the presence of self-antigen. These mechanisms have not been assessed in a normal polyclonal repertoire because of an inability to detect rare antigen-specific B cells. Using a novel detection and enrichment strategy to assess polyclonal self-antigen–specific B cells, we find no evidence of deletion or anergy of cells specific for antigen not bound to membrane, and tolerance to these types of antigens appears to be largely maintained by the absence of T cell help. In contrast, a combination of deleting cells expressing receptors with high affinity for antigen with anergy of the undeleted lower affinity cells maintains tolerance to ubiquitous membrane-bound self-antigens.
The British journal of nutrition · 2015
Abstract Probiotics and prebiotics, mainly commercialised as food ingredients and also as supplements, are considered highly profitable niche markets. However, in recent years, the food industry has suffered from a series of health claim restrictions on probiotics and prebiotics in many parts of the world, including those made by the European Food Safety Authority. Therefore, we reviewed the core benefits of probiotic and prebiotic consumption on health. A number of studies have examined the prevention and/or management of intestinal infections, respiratory tract infections, CVD, osteoporosis, urogenital infections, cavities, periodontal disease and halitosis, allergic reactions, inflammatory bowel disease and irritable bowel syndrome and Helicobacter pylori gastric infections. In fact, a deeper understanding of the mechanisms involved in human microbiota and immune system modulation by probiotics and prebiotics relies on continuous efforts to establish suitable biomarkers of health and diseases risk factors for the design of clinical trials required for health claim approval. In spite of the promising results, the performance of large, long-term, well-planned, well-aligned clinical studies is crucial to provide more reliability and a more solid basis for the outcomes achieved and to support the potential use of probiotics and prebiotics in clinical practice.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Cells · 2026 · Journal Article
Rago L, García-Lainez G, Maicas M, Pardo E, et al.
The American journal of clinical nutrition · 2026 · Journal Article
Merrill LC, Martínez RL, Palacios N, Dawson-Hughes B, et al.
Frontiers in microbiology · 2025 · Journal Article
Khang J, Martinez R, Brag K, McGee JS
Veterinary microbiology · 2024 · Journal Article
Gonzálvez M, Cano-Terriza D, Fayos M, Moroni B, et al.
JMIR formative research · 2024 · Journal Article
Marras C, Labarga M, Ginard D, Carrascosa JM, et al.
Frontiers in oncology · 2024 · Journal Article
Pellicano AA, Benites BM, Paschoa AFN, Oliveira LC, et al.
The Journal of physiology · 2023 · Journal Article
Musci RV, Andrie KM, Walsh MA, Valenti ZJ, et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023 · Journal Article
Afzali MF, Pannone SC, Martinez RB, Campbell MA, et al.
Le infezioni in medicina · 2022 · Journal Article
Gonzales-Zamora JA, Ponce-Rosas L, Martinez R
The Journal of nervous and mental disease · 2022 · Journal Article
Dike CC, Briz L, Fadus M, Martinez R, et al.
Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2021 · Journal Article
Spittler AP, Afzali MF, Martinez RB, Culver LA, et al.
The Psychiatric clinics of North America · 2021 · Journal Article
Candilis PJ, Martinez R
The journal of the American Academy of Psychiatry and the Law · 2020 · Editorial
Martinez R, Candilis P
Translational animal science · 2020 · Journal Article
Much ML, Leatherwood JL, Martinez RE, Silvers BL, et al.
Revista medica de Chile · 2019 · Case Reports
Schiappacasse G, Acevedo A, Martínez R, Escobar J, et al.
Focus (American Psychiatric Publishing) · 2019 · Journal Article
Friedman SH, Martinez RP
The journal of the American Academy of Psychiatry and the Law · 2019 · Journal Article
Cerny-Suelzer CA, Ferranti J, Wasser T, Janofsky JS, et al.
The journal of the American Academy of Psychiatry and the Law · 2019 · Guideline
Cerny-Suelzer CA, Ferranti J, Wasser T, Janofsky JS, et al.
The journal of the American Academy of Psychiatry and the Law · 2018 · Journal Article
Martinez R
The journal of the American Academy of Psychiatry and the Law · 2017 · Journal Article
Westmoreland P, Johnson C, Stafford M, Martinez R, et al.
Journal of clinical and experimental dentistry · 2017 · Case Reports
Niklander S, Marín C, Martínez R, Esguep A
The journal of the American Academy of Psychiatry and the Law · 2016 · Journal Article
Friedman SH, Appel JM, Ash P, Frierson RL, et al.
Conservation biology : the journal of the Society for Conservation Biology · 2015 · Case Reports
Zorrilla I, Martinez R, Taggart MA, Richards N
The British journal of nutrition · 2015 · Journal Article
Martinez RC, Bedani R, Saad SM
The journal of the American Academy of Psychiatry and the Law · 2014 · Journal Article
Hanson A, Martinez R, Candilis PJ
Cardiology in the young · 2013 · Journal Article
Martinez RM, Ringewald JM, Fontanet HL, Quintessenza JA, et al.
Journal of community health · 2012 · Journal Article
Martinez RM, Nordt SP, Cantrell FL
The Journal of experimental medicine · 2012 · Journal Article
Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, et al.
Journal of molecular endocrinology · 2012 · Journal Article
Auld KL, Berasi SP, Liu Y, Cain M, et al.
Skeletal radiology · 2012 · Journal Article
Monsignore LM, Martinez R, Simão MN, Teixeira SR, et al.
The journal of the American Academy of Psychiatry and the Law · 2012 · Editorial
Martinez R
The journal of the American Academy of Psychiatry and the Law · 2012 · Editorial
Candilis PJ, Martinez R
Journal of immunology (Baltimore, Md. : 1950) · 2012 · Journal Article
Martinez RJ, Zhang N, Thomas SR, Nandiwada SL, et al.
Cardiology in the young · 2011 · Journal Article
Said SM, Dearani JA, Silversides CK, Martinez RM, et al.
Pediatric research · 2025 · Journal Article
Trak-Fellermeier MA, Galvan R, Hernandez J, Martinez-Motta P, et al.
Archives of osteoporosis · 2025 · Journal Article
Petrie A, Trak-Fellermeier MA, Hernandez J, Macchi A, et al.
AIDS and behavior · 2013 · Journal Article
Mendoza JA, Paul ME, Schwarzwald H, Liu Y, et al.
Cardiology in the young · 2012 · Journal Article
Dadlani GH, Braley K, Sochet A, Marcet K, et al.
Revista do Instituto de Medicina Tropical de Sao Paulo · 2026 · Case Reports
Oliveira RDR, Martinez R, Gaspar GG, Louzada Junior P, et al.
BMC infectious diseases · 2022 · Case Reports
Tabliago NRA, Maish D, Martinez RM, Shelly MA, et al.
BMC infectious diseases · 2022 · Case Reports
Tabliago NRA, Maish D, Martinez RM, Shelly MA, et al.
Expert review of clinical pharmacology · 2018 · Journal Article
Ruiz Iban MA, Benavides J, Forero JP, Bittelman S, et al.
Frontiers in immunology · 2023 · Journal Article
Egri N, Calderón H, Martinez R, Vazquez M, et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012 · Comparative Study
Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, et al.
Tropical medicine & international health : TM & IH · 2015 · Journal Article
Savarese LG, Monsignore LM, de Andrade Hernandes M, Martinez R, et al.
Lupus · 2021 · Journal Article
Martínez REM, Herrera JLA, Pérez RAD, Mendoza CA, et al.
World journal of gastrointestinal endoscopy · 2026 · Journal Article
Corsi O, Martinez R, Aguirre J, Friedrich I, et al.
Lupus · 2016 · Journal Article
Machado Escobar MA, Yacuzzi MS, Martinez RN, González Lucero L, et al.
International journal of rheumatic diseases · 2011 · Consensus Statement
Li-Yu J, Perez EC, Cañete A, Bonifacio L, et al.
Medicine · 2019 · Evaluation Study
Martinez R, Reddy N, Mulligan EP, Hynan LS, et al.
Ignition: An End-to-End Supervised Model for Training Simulated Self-Driving Vehicles
We introduce Ignition: an end-to-end neural network architecture for training unconstrained self-driving vehicles in simulated environments. The model is a ResNet-18 variant, which is fed in images from the front of a si
Tending Towards Stability: Convergence Challenges in Small Language Models
Increasing the number of parameters in language models is a common strategy to enhance their performance. However, smaller language models remain valuable due to their lower operational costs. Despite their advantages, s
Meta-Pretraining for Zero-Shot Cross-Lingual Named Entity Recognition in Low-Resource Philippine Languages
Named-entity recognition (NER) in low-resource languages is usually tackled by finetuning very large multilingual LMs, an option that is often infeasible in memory- or latency-constrained settings. We ask whether small d
What is the Best Sequence Length for BABYLM?
Transformer language models typically operate with a fixed-length context window, which has grown in step with large-scale pretraining datasets. In the BabyLM Challenge, however, many past submissions have defaulted to u
Theory of Machine Networks: A Case Study
We propose a simplification of the Theory-of-Mind Network architecture, which focuses on modeling complex, deterministic machines as a proxy for modeling nondeterministic, conscious entities. We then validate this archit
From Babble to Words: Pre-Training Language Models on Continuous Streams of Phonemes
Language models are typically trained on large corpora of text in their default orthographic form. However, this is not the only option; representing data as streams of phonemes can offer unique advantages, from deeper i
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Cardiology in the young · 2011 · Journal Article
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, et al.