📇 Rhumatologue · VALENCIENNES · (59) · Libéral

MME Roxana MARTIN

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Auteur de référence en rhumatologie
33 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
126.7 rhumatos / 100 000 hab. — département bien doté

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📍 VALENCIENNES (59)LibéralRPPS 10100231116

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial

Lancet (London, England) · 2020

📚 215 citations🎯 RCR 13.39Top 2% NIH🩺 Clinique🔓 Open Access

Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial

Annals of the rheumatic diseases · 2023

📚 55 citations🎯 RCR 8.84Top 3% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Fine particulate matter components and interstitial lung disease in rheumatoid arthritis

The European respiratory journal · 2022

📚 48 citations🎯 RCR 4.97Top 8% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

BackgroundExposure to ambient fine particulate matter with an aerodynamic diameter <2.5 μg·m−3(PM2.5) is a risk factor for pulmonary and systemic autoimmune diseases; however, evidence on which PM2.5chemical components are more harmful is still scant. Our goal is to investigate potential associations between major PM2.5components and interstitial lung disease (ILD) onset in rheumatoid arthritis (RA).MethodsNew-onset RA subjects identified from a US healthcare insurance database (MarketScan) were followed for new onset of RA-associated ILD (RA-ILD) from 2011 to 2018. Annual concentrations of ambient PM2.5chemical components (i.e.sulfate, nitrate, ammonium, organic matter, black carbon, mineral dust and sea salt) were estimated by combining satellite retrievals with chemical transport modelling and refined by geographically weighted regression. Exposures from 2006 up to 1 year before ILD onset or end of study were assigned to subjects based on their core-based statistical area or metropolitan division codes. A novel time-to-event quantile-based g (generalised)-computation approach was used to estimate potential associations between RA-ILD onset and the exposure mixture of all seven PM2.5chemical components adjusting for age, sex and prior chronic obstructive pulmonary disease (as a proxy for smoking).ResultsWe followed 280 516 new-onset RA patients and detected 2194 RA-ILD cases across 1 394 385 person-years. The adjusted hazard ratio for RA-ILD onset was 1.54 (95% CI 1.47–1.63) per every decile increase in all seven exposures. Ammonium, mineral dust and black carbon contributed more to ILD risk than the other PM2.5components.ConclusionExposure to components of PM2.5, particularly ammonium, increases ILD risk in RA.

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MME Roxana MARTIN

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Top publications · les plus citées

Publications scientifiques (33) — classées par pathologie

Anti-IL-178

Transversal6

Épidémiologie & registres4

IA en rhumatologie4

Activité physique / Rééducation3

Case report / série2

Génétique2

Pédiatrie2

Recommandations2

Revue générale2

Anti-TNF1

Essai clinique1

Lombalgie1

Qualité de vie / PROMs1

Revue / méta-analyse1

Spondyloarthrite1

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