📇 Rhumatologue · EPAGNY METZ TESSY · (74) · Mixte

MME CHRISTINE MARTIN

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Auteur de référence en rhumatologie
27 articles scientifiques publiés — un praticien à la pointe de la recherche
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6 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
131.5 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 EPAGNY METZ TESSY (74)MixteRPPS 10003116950

📊 Reconnaissance scientifique : 32/100📝 98 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

European journal of endocrinology · 2023

📚 43 citations🎯 RCR 6.26Top 5% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Objective Drugs targeting the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) are emerging as treatments for type-2 diabetes and obesity. GIP acutely decreases serum markers of bone resorption and transiently increases bone formation markers in short-term clinical investigations. However, it is unknown whether GIP acts directly on bone cells to mediate these effects. Using a GIPR-specific antagonist, we aimed to assess whether GIP acts directly on primary human osteoclasts and osteoblasts. Methods Osteoclasts were differentiated from human CD14+ monocytes and osteoblasts from human bone. GIPR expression was determined using RNA-seq in primary human osteoclasts and in situ hybridization in human femoral bone. Osteoclastic resorptive activity was assessed using microscopy. GIPR signaling pathways in osteoclasts and osteoblasts were assessed using LANCE cAMP and AlphaLISA phosphorylation assays, intracellular calcium imaging and confocal microscopy. The bioenergetic profile of osteoclasts was evaluated using Seahorse XF-96. Results GIPR is robustly expressed in mature human osteoclasts. GIP inhibits osteoclastogenesis, delays bone resorption, and increases osteoclast apoptosis by acting upon multiple signaling pathways (Src, cAMP, Akt, p38, Akt, NFκB) to impair nuclear translocation of nuclear factor of activated T cells-1 (NFATc1) and nuclear factor-κB (NFκB). Osteoblasts also expressed GIPR, and GIP improved osteoblast survival. Decreased bone resorption and improved osteoblast survival were also observed after GIP treatment of osteoclast–osteoblast co-cultures. Antagonizing GIPR with GIP(3–30)NH2 abolished the effects of GIP on osteoclasts and osteoblasts. Conclusions GIP inhibits bone resorption and improves survival of human osteoblasts, indicating that drugs targeting GIPR may impair bone resorption, whilst preserving bone formation.

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation

JCI insight · 2022

📚 40 citations🎯 RCR 3.57Top 13% NIH🔓 Open Access📄 PDF gratuit ↗

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Secreted phospholipase A 2 -IIA (sPLA 2 -IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA 2 -IIA efficiently hydrolyzes bacterial membranes. Here, we show that sPLA 2 -IIA affects the immune system by acting on the intestinal microbial flora. Using mice overexpressing transgene-driven human sPLA 2 -IIA, we found that the intestinal microbiota was critical for both induction of an immune phenotype and promotion of inflammatory arthritis. The expression of sPLA 2 -IIA led to alterations of the intestinal microbiota composition, but housing in a more stringent pathogen-free facility revealed that its expression could affect the immune system in the absence of changes to the composition of this flora. In contrast, untargeted lipidomic analysis focusing on bacteria-derived lipid mediators revealed that sPLA 2 -IIA could profoundly alter the fecal lipidome. The data suggest that a singular protein, sPLA 2 -IIA, produces systemic effects on the immune system through its activity on the microbiota and its lipidome.

Holoprosencephaly: Review of Embryology, Clinical Phenotypes, Etiology and Management

Children (Basel, Switzerland) · 2023

📚 20 citations🎯 RCR 3.78Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

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Holoprosencephaly (HPE) is the most common malformation of the prosencephalon in humans. It is characterized by a continuum of structural brain anomalies resulting from the failure of midline cleavage of the prosencephalon. The three classic subtypes of HPE are alobar, semilobar and lobar, although a few additional categories have been added to this original classification. The severity of the clinical phenotype is broad and usually mirrors the radiologic and associated facial features. The etiology of HPE includes both environmental and genetic factors. Disruption of sonic hedgehog (SHH) signaling is the main pathophysiologic mechanism underlying HPE. Aneuploidies, chromosomal copy number variants and monogenic disorders are identified in a large proportion of HPE patients. Despite the high postnatal mortality and the invariable presence of developmental delay, recent advances in diagnostic methods and improvements in patient management over the years have helped to increase survival rates. In this review, we provide an overview of the current knowledge related to HPE, and discuss the classification, clinical features, genetic and environmental etiologies and management.

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MME CHRISTINE MARTIN

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Activité de recherche & publications

Publications académiques en France

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Publications scientifiques (27) — classées par pathologie

Transversal15

Épidémiologie & registres3

Pédiatrie2

Vascularites2

Activité physique / Rééducation1

Arthrite juvénile1

Corticothérapie1

Gériatrie1

Microbiote1

Revue générale1

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