📇 Rhumatologue ·
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Praticien-chercheur
10 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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Skeletal radiology · 2005
Lupus · 2007
The aim of this study was to identify risk factors for lupus nephritis including clinical, laboratory, and ethnic factors in a cohort of lupus patients in New Zealand. A retrospective study of patients from two teaching hospitals in Auckland, New Zealand. Patients were selected if they had attended as either an inpatient, or a rheumatology outpatient between 2000 and 2005. 170 patients had SLE according to ACR classification. Lupus nephritis (LN) was diagnosed according to ACR criteria. Clinical, laboratory, and ethnic data were gathered from the patient notes. Twenty-four patients had LN at diagnosis and 32 patients developed LN after diagnosis. LN was associated with serositis ( P = 0.008), cutaneous vasculitis ( P = 0.026), anaemia ( P = 0.005), CRP elevation >6 months ( P < 0.001), hypocomplementaemia >6 months ( P < 0.0001). Patients with elevated doublestranded DNA (dsDNA) (>5 × normal) were more likely to develop type IV LN ( P = 0.0096). Forty-one percent of patients were Caucasian, 12% Maori, 23% Pacific People, 16% Asian, 6% Indian. Maori patients with SLE (odds ratio (OR) = 8.47, 95% confidence interval (CI) = 2.11—33.96, P = 0.002), and Pacific People (OR = 3.11, 95% CI = 1.29—11.48, P = 0.014) had increased risk for developing LN. Anaemia at presentation (hazard ratio (HR) 3.2, 95% CI = 1.4—7.1, P = 0.004), and low complement >6 months (HR = 3.4, 95% CI = 1.4—8.7, P = 0.008) were independent risk factors for developing LN after SLE diagnosis. In New Zealand, Pacific People and Maori patients with SLE have a higher incidence of LN, and patients with anaemia and hypocomplementaemia are more likely to develop LN after diagnosis. Patients with high dsDNA levels are more likely to develop Type IV lupus nephritis. Lupus (2007) 16, 830—837.
Respirology (Carlton, Vic.) · 2012
ABSTRACTBackground and objective: The six‐minute walk test (6MWT) is a validated field test in the assessment of interstitial lung disease but may not be so useful in scleroderma (SSc) lung disease. The aim of this study was to determine the reliability of the 6MWT in patients with SSc and correlate results with morphological and functional measures of disease severity.Methods: Thirty patients (24 female, mean age 47, mean diffusing capacity of carbon monoxide 65%, vital capacity 77% predicted) with American College of Rheumatology classification of SSc performed two 6MWT using various oximetry sites, 1 week apart, and underwent SSc‐specific disease severity and quality‐of‐life measurements, lung function, high‐resolution computed tomography and echocardiography.Results: There was good reliability between the two 6MWT (distance; intraclass correlation coefficient 0.95, r = 0.89, Borg; intraclass correlation coefficient 0.85, r = 0.91, both P < 0.00 for r), and Bland Altman plots demonstrate good agreement between measures 1 week apart. Forehead and finger oximetry were more reliable than earlobe (intraclass correlation coefficient 0.64, 0.60, 0.24; r = 0.46, 0.47, 0.14; n = 22, 17, 7, respectively). Forehead desaturation correlated with forced expiratory volume in 1 s (r = 0.55, P = 0.01) and forced vital capacity (r = 0.59, P = 0.01). Distance correlated with all physiological measures: forced expiratory volume in 1 s (r = 0.55, P = 0.01), forced vital capacity (r = 0.61, P = 0.01) and diffusing capacity of carbon monoxide (r = 0.42, P = 0.05). Computed tomography extent and patterns of disease correlated poorly with 6MWT measures, and global measures of SSc correlated only with post‐test Borg score.Conclusions: The 6MWT is feasible and reliable in SSc lung disease, but forehead oximetry should be used. The test measurements correlate reasonably but variably with functional and morphological measures of disease severity.
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Annals of the rheumatic diseases · 2009 · Case Reports
Ly J, Pinto C, Doyle A, Dalbeth N, et al.
The New Zealand medical journal · 2008 · Journal Article
Chan G, Goh F, Hodgson T, Hsu E, et al.
Military medicine · 2008 · Case Reports
Blecher CB, Ly JQ
Skeletal radiology · 2005 · Journal Article
Beall DP, Sweet CF, Martin HD, Lastine CL, et al.
The New Zealand medical journal · 2008 · Clinical Trial
Colvine K, Kerr AJ, McLachlan A, Gow P, et al.
The New Zealand medical journal · 2007 · Journal Article
Ly J, Gow P, Dalbeth N
The Journal of the Oklahoma State Medical Association · 2007 · Journal Article
Banks KP, Beall DP, McCollum MJ, Ly JQ, et al.
Current problems in diagnostic radiology · 2005 · Journal Article
Kirby AB, Beall DP, Murphy MP, Ly JQ, et al.
Lupus · 2007 · Journal Article
Burling F, Ng J, Thein H, Ly J, et al.
The New Zealand medical journal · 2008 · Clinical Trial
Colvine K, Kerr AJ, McLachlan A, Gow P, et al.
Respirology (Carlton, Vic.) · 2012 · Journal Article
Wilsher M, Good N, Hopkins R, Young P, et al.